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Circulating microRNAs as markers of dietary intake

English title Circulating microRNAs as markers of dietary intake
Applicant Pralong François
Number 160617
Funding scheme HDHL Joint Programming Initiative
Research institution Division d'endocrinologie, diabétologie et du métabolisme Département de médecine interne - CHUV
Institution of higher education University of Lausanne - LA
Main discipline Nutritional Research, Vitaminology
Start/End 01.01.2015 - 31.12.2017
Approved amount 235'451.00
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All Disciplines (3)

Discipline
Nutritional Research, Vitaminology
Clinical Nutritional Research
Clinical Endocrinology

Keywords (3)

microRNA; dietary marker; metabolic status

Lay Summary (French)

Lead
Le projet MIRDIET est un projet destiné à élucider le rôle potentiel des microRNAS comme marqueurs de la prise alimentaire.
Lay summary

Les études nutritionnelles se basent généralement sur des éléments subjectifs tels que les auto-questionnaires de prise alimentaire. L'utilisation de biomarqueurs pourrait permettre d'évaluer objectivement la prise alimentaire des points de vue qualitatifs et quantitatifs. Les microRNAs sont des RNA non codants qui ont la capacité de contrôler l'expression des gènes au niveau post-transcriptionnel et sont relâchés dans la circulation sanguine.

Le projet MIRDIET propose d'étudier la réponse différentielles de microRNAs spécifiques en fonction de différentes interventions nutritionnelles bien contrôlées. La possibilité d'utiliser les microRNAs comme des signatures de la prise alimentaire sera ainsi évaluée dans des études utilisant des interventions nutritionnelles différentes et conduites au sein d'un consortium regroupant plusieurs groupes de recherche en France, en Hollande et en Suisse.

Direct link to Lay Summary Last update: 30.03.2015

Responsible applicant and co-applicants

Employees

Abstract

Nutritional studies generally use self-reported dietary intakes which subjective nature of assessment methods is challenging to obtain accurate dietary intake and nutritional status. The use of molecular dietary biomarkers may objectively assess quantitative and qualitative dietary intake without the bias of self-reported dietary intake. As a key tissue in inter-organ crosstalk, the adipose tissue is, like blood, an easily accessible tissue using painless sampling. MicroRNAs are noncoding RNAs that post-transcriptionally control gene expression and can be released by cells, circulating in blood in a stable form. Recently, microRNAs were identified as a new class of biomarkers in cancer and cardiovascular health fields. MIRDIET aims at identifying differential responses of specific circulating microRNAs that occur during carefully assessed dietary interventions in individuals with various metabolic status. The biomarker potential of microRNA signature will be validated at the circulating level using blood samples from both same and unrelated dietary interventions. This original approach of microRNA selection provides a unique way to identify novel quantitative nutritional biomarkers.
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