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Swiss HIV Cohort Study (SHCS)

English title Swiss HIV Cohort Study (SHCS)
Applicant Günthard Huldrych Fritz
Number 148522
Funding scheme Cohort Studies Large
Research institution Klinik für Infektionskrankheiten und Spitalhygiene Universitätsspital Zürich
Institution of higher education University of Zurich - ZH
Main discipline Internal Medicine
Start/End 01.01.2014 - 31.12.2017
Approved amount 10'528'000.00
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All Disciplines (23)

Discipline
Internal Medicine
Neurology, Psychiatry
Gynaecology
Clinical Cardiovascular Research
Clinical Cancer Research
Clinical Immunology and Immunopathology
Clinical Pharmacology
Infectious Diseases
Cellular Biology, Cytology
Pharmacology, Pharmacy
Medical Microbiology
Cancer
Methods of Epidemiology and Preventive Medicine
Immunology, Immunopathology
Clinical Endocrinology
Clinical Pathophysiology
Medical Statistics
Medico-Social Problems of Youth
Ethology
Genetics
Addictive Diseases
Molecular Biology
Experimental Microbiology

Keywords (8)

Immune deficiency; Antiretroviral therapy; HIV; drug resistance; side effects; toxicity; virus host interactions; hiv epidemic

Lay Summary (German)

Lead
Die Schweizerische HIV Kohortenstudie (www.shcs.ch) ist eine klinische, multizentrische Langzeit-Studie, die HIV infizierte Menschen einschliesst. Sie forscht im Bereich der HIV-Medizin, der Grundlagen-, der Sozialen und Präventiven Wissenschaften. Sie wurde 1988 begonnen, schliesst bisher ~19000 PatientInnen ein. Sie ist entscheidend für die hohe Qualität der HIV-Medizin in der Schweiz und für das bessere Verständnis der Wechselwirkung zwischen dem HI-Virus und dem menschlichen Organismus.
Lay summary
Die Schweizerische HIV Kohortenstudie (SHCS) wurde 1988 gestartet. Seither wurden ~19000 PatientInnen eingeschlossen und 2013 wurden beinahe 9000 aktiv betreut. 2003 wurde die Swiss Mother and Child HIV Cohort Study (MoCHIV) in die SHCS integriert. Schon früh vereinte die SHCS klinisch, translational, grundlagen- und sozial wissenschaftlich ausgerichtete Forschende. Bisher sind mehr als 700 in Fachzeitschriften erschienene wissenschaftliche Artikel aus der SHCS hervorgegangen, was deren Bedeutung unterstreicht. Eine ihrer Besonderheiten ist, dass sie jeweils rasch auf neue wissenschaftliche Erkenntnisse und Herausforderungen im Bereich der HIV-Forschung reagierte. Die SHCS ist repräsentativ für die Schweiz: mindestens 45% aller HIV-Infizierten, 75% aller PatientInnen mit AIDS und 75% aller Individuen in der Schweiz die antiretroviral behandelt werden nehmen an der Studie teil. Sie ist entscheidend für die hohe HIV-Behandlungsqualität in der Schweiz und leistet einen entscheidenden Beitrag zur Verhinderung von Neuinfektionen. Sie studiert medikamentöse Langzeitnebenwirkungen, Uebertragung von HIV, Koinfektionen und Resistenz, optimiert die antiretrovirale Therapie, bekämpft die Uebertragung von HIV von der Mutter auf das Kind und erforscht die Wechselwirkung zwischen dem HI Virus und dem menschlichen Organismus intensiv. Insbesondere laufen Studien, die letztlich auf die Entwicklung von Impfungen hinauslaufen und die verstehen helfen, warum es bisher nicht gelingt HIV zu heilen. Sozialwissenschaftliche Projekte laufen, um die Auswirkungen der HIV Infektion auf die Psyche und die Beschäftigungssituation zu verstehen. Zusammenfassend stellt die SHCS ein modernes Forschungsinstrument dar, das direkt den PatientInnen zu Gute kommt, einen grossen Beitrag zur Eindämmung der HIV-Epidemie in der Schweiz leistet und hilft, die Biologie der HIV Infektion im Menschen besser zu verstehen, was die Voraussetzung ist für eine wirksame Impfung oder eine Heilung.  
Direct link to Lay Summary Last update: 03.12.2013

Lay Summary (English)

Lead
The Swiss HIV Cohort Study (www.shcs.ch) is a multicenter, clinic based longitudinal study enrolling HIV infected individuals in Switzerland. It aims at performing research in the field of HIV medicine, basic and social sciences and public health. It started 1988, includes ~19000 patients, is instrumental for the high quality of HIV-care in Switzerland, for monitoring the HIV epidemic and co-infections, and has contributed to better understanding interactions between HIV and the human host.
Lay summary
The SHCS is a fully established cohort that was started in 1988. Since then, ~19000  patients were enrolled and in 2013, almost 9000 were followed actively. From the beginning, the SHCS was an open, longitudinal cohort, enrolling continuously individuals from all transmission groups. In 2003 the “Swiss Mother and Child HIV Cohort Study” (MoCHiV) was integrated into the SHCS. Early on, the SHCS unified clinical, translational, basic, social and epidemiological science, as well more recently also nursing research. The considerable scientific impact of the SHCS and MoCHiV is illustrated by more than 700 publications in peer reviewed journals that directly emerged from these studies, respectively were made possible by significant contributions of the SHCS. One of the hallmarks of the SHCS is that this research network was able to rapidly respond to new scientific findings and challenges in the field. The SHCS is nationwide highly representative. At least 45% of all HIV-infected individuals living in Switzerland, 75% of all patients with AIDS and 75% of all patients on antiretroviral treatment participate in the SHCS. The SHCS has a strong impact on public health in Switzerland and includes: (i) Providing high quality data on HIV transmission, (ii) preventing HIV-transmission by optimal treatment and counseling, (iii) informing care givers on optimal screening and treatment interventions, (iv) providing key data on how to prevent and treat opportunistic infections, (v) monitoring co-infections and other  sexually transmitted infections (STI), (vi) providing behavioral data on sexual activities, on prevention measures, substance abuse, depression prevalence, employment status, and activities of daily living, (vii) performing cost effectiveness studies with regard to diagnostic procedures, (viii) monitoring transmission of HIV drug resistance, (ix) continuously delivering high quality data for prevention campaigns, (x) providing feedback to physicians on treatment outcome and mortality compared to other settings. 
Direct link to Lay Summary Last update: 03.12.2013

Responsible applicant and co-applicants

Name Institute

Employees

Publications

Publication
Associations Between Antiretroviral Treatment and Avascular Bone Necrosis: The Swiss HIV Cohort Study.
Bayard Cornelia, Ledergerber Bruno, Flepp Markus, Lecompte Thanh, Moulin Estelle, Hoffmann Matthias, Weber Rainer, Staehelin Cornelia, Di Benedetto Caroline, Fux Christoph A, Tarr Philip E, Hasse Barbara, Hasse Barbara (2017), Associations Between Antiretroviral Treatment and Avascular Bone Necrosis: The Swiss HIV Cohort Study., in Open forum infectious diseases, 4(4), 177-177.
The Presence of Human Immunodeficiency Virus-Associated Neurocognitive Disorders Is Associated With a Lower Adherence to Combined Antiretroviral Treatment.
Kamal Susan, Locatelli Isabella, Wandeler Gilles, Sehhat Asemaneh, Bugnon Olivier, Metral Melanie, Du Pasquier Renaud, Gutbrod Klemens, Cavassini Matthias, Schneider Marie P, Swiss HIV Cohort Study (2017), The Presence of Human Immunodeficiency Virus-Associated Neurocognitive Disorders Is Associated With a Lower Adherence to Combined Antiretroviral Treatment., in Open forum infectious diseases, 4(2), 070-070.
Reply to correspondence ‘Conserved signatures indicate HIV-1 transmission is under strong selection and thus is not a “stochastic” process’ by Gonzalez et al., Retrovirology 2017
Oberle Corinna S., Magnus Carsten, Joos Beda, Rusert Peter, Beauparlant David, Kouyos Roger, Trkola Alexandra, Metzner Karin J., Günthard Huldrych F. (2017), Reply to correspondence ‘Conserved signatures indicate HIV-1 transmission is under strong selection and thus is not a “stochastic” process’ by Gonzalez et al., Retrovirology 2017, in Retrovirology, 14(1), 14-14.
Parent-offspring regression to estimate the heritability of an HIV-1 trait in a realistic setup
Bachmann Nadine, Turk Teja, Kadelka Claus, Marzel Alex, Shilaih Mohaned, Böni Jürg, Aubert Vincent, Klimkait Thomas, Leventhal Gabriel E., Günthard Huldrych F., Kouyos Roger (2017), Parent-offspring regression to estimate the heritability of an HIV-1 trait in a realistic setup, in Retrovirology, 14(1), 33-33.
One-year mortality of HIV-positive patients treated for rifampicin- and isoniazid- susceptible tuberculosis in Eastern Europe, Western Europe and Latin America
Podlekareva Daria N., TB:HIV Study writing Group (2017), One-year mortality of HIV-positive patients treated for rifampicin- and isoniazid- susceptible tuberculosis in Eastern Europe, Western Europe and Latin America, in AIDS, (3), 375-384.
Effect of Immediate Initiation of Antiretroviral Treatment in HIV-Positive Individuals Aged 50 Years or Older.
Lodi Sara, Costagliola Dominique, Sabin Caroline, Del Amo Julia, Logan Roger, Abgrall Sophie, Reiss Peter, van Sighem Ard, Jose Sophie, Blanco Jose-Ramon, Hernando Victoria, Bucher Heiner C, Kovari Helen, Segura Ferran, Ambrosioni Juan, Gogos Charalambos A, Pantazis Nikos, Dabis Francois, Vandenhende Marie-Anne, Meyer Laurence, Seng Rémonie, Gill M John, Krentz Hartmut, Phillips Andrew N, Porter Kholoud, Grinsztejn Beatriz, Pacheco Antonio G, Muga Roberto, Tate Janet, Justice Amy, Hernán Miguel A (2017), Effect of Immediate Initiation of Antiretroviral Treatment in HIV-Positive Individuals Aged 50 Years or Older., in Journal of acquired immune deficiency syndromes (1999), (3), 311-318.
Life expectancy in HIV-positive persons in Switzerlandmatched comparison with general population
Gueler Aysel, Moser André, Calmy Alexandra, Günthard Huldrych F., Bernasconi Enos, Furrer Hansjakob, Fux Christoph A., Battegay Manuel, Cavassini Matthias, Vernazza Pietro, Zwahlen Marcel, Egger Matthias (2017), Life expectancy in HIV-positive persons in Switzerlandmatched comparison with general population, in AIDS, 31(1), 472-436.
Incidence of cancer and overall risk of mortality in individuals treated with raltegravir-based and non-raltegravir-based combination antiretroviral therapy regimens.
Cozzi-Lepri A, Zangerle R, Machala L, Zilmer K, Ristola M, Pradier C, Kirk O, Sambatakou H, Fätkenheuer G, Yust I, Schmid P, Gottfredsson M, Khromova I, Jilich D, Flisiak R, Smidt J, Rozentale B, Radoi R, Losso M H, Lundgren J D, Mocroft A, Mocroft A (2017), Incidence of cancer and overall risk of mortality in individuals treated with raltegravir-based and non-raltegravir-based combination antiretroviral therapy regimens., in HIV medicine, 1-1.
Mining for pairs: shared clinic visit dates identify steady HIV-positive partnerships
Marzel A, Shilaih M, Turk T, Campbell NK, Yang W-L, Böni J, Yerly S, Klimkait T, Aubert V, Furrer H, Calmy A, Battegay M, Cavassini M, Bernasconi E, Schmid P, Metzner KJ, Günthard HF, Kouyos RD (2017), Mining for pairs: shared clinic visit dates identify steady HIV-positive partnerships, in HIV Medicine, (9), 667-676.
Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T Cell Decline and Per-Parasite Pathogenicity.
Bertels Frederic, Marzel Alex, Leventhal Gabriel, Mitov Venelin, Fellay Jacques, Günthard Huldrych F, Böni Jürg, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Battegay Manuel, Rauch Andri, Cavassini Matthias, Calmy Alexandra, Bernasconi Enos, Schmid Patrick, Scherrer Alexandra U, Müller Viktor, Bonhoeffer Sebastian, Kouyos Roger, Regoes Roland R, Swiss HIV Cohort Study (2017), Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T Cell Decline and Per-Parasite Pathogenicity., in Molecular biology and evolution, 1-1.
Impact of early versus deferred antiretroviral therapy on estimated glomerular filtration rate in HIV-positive individuals in the START trial.
Achhra Amit C, Mocroft Amanda, Ross Michael, Ryom-Nielson Lene, Avihingsanon Anchalee, Bakowska Elzbieta, Belloso Waldo, Clarke Amanda, Furrer Hansjakob, Lucas Gregory M, Ristola Matti, Rassool Mohammed, Ross Jonathan, Somboonwit Charurut, Sharma Shweta, Wyatt Christina (2017), Impact of early versus deferred antiretroviral therapy on estimated glomerular filtration rate in HIV-positive individuals in the START trial., in International journal of antimicrobial agents, 50(3), 453-460.
CD4:CD8 Ratio and CD8 Count as Prognostic Markers for Mortality in Human Immunodeficiency Virus-Infected Patients on Antiretroviral Therapy: The Antiretroviral Therapy Cohort Collaboration (ART-CC).
Trickey Adam, May Margaret T, Schommers Philipp, Tate Jan, Ingle Suzanne M, Guest Jodie L, Gill M John, Zangerle Robert, Saag Mike, Reiss Peter, Monforte Antonella d'Arminio, Johnson Margaret, Lima Viviane D, Sterling Tim R, Cavassini Matthias, Wittkop Linda, Costagliola Dominique, Sterne Jonathan A C, Sterne Jonathan A C (2017), CD4:CD8 Ratio and CD8 Count as Prognostic Markers for Mortality in Human Immunodeficiency Virus-Infected Patients on Antiretroviral Therapy: The Antiretroviral Therapy Cohort Collaboration (ART-CC)., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, (6), 959-966.
Assessing the danger of self-sustained HIV epidemics in heterosexuals by population based phylogenetic cluster analysis.
Turk Teja, Bachmann Nadine, Kadelka Claus, Böni Jürg, Yerly Sabine, Aubert Vincent, Klimkait Thomas, Battegay Manuel, Bernasconi Enos, Calmy Alexandra, Cavassini Matthias, Furrer Hansjakob, Hoffmann Matthias, Günthard Huldrych F, Kouyos Roger D (2017), Assessing the danger of self-sustained HIV epidemics in heterosexuals by population based phylogenetic cluster analysis., in eLife, 6, 1-1.
HLA-B*14:02-RESTRICTED ENV-SPECIFIC CD8+ T-CELL ACTIVITY HAS HIGHLY POTENT ANTIVIRAL EFFICACY ASSOCIATED WITH IMMUNE CONTROL OF HIV INFECTION.
Leitman Ellen M, Willberg Christian B, Tsai Ming-Han, Chen Huabiao, Buus Søren, Chen Fabian, Riddell Lynn, Haas David, Fellay Jacques, Goedert James J, Piechocka-Trocha Alicja, Walker Bruce D, Martin Jeffrey, Deeks Steven, Wolinsky Steven M, Martinson Jeremy, Martin Maureen, Qi Ying, Sáez-Cirión Asier, Yang Otto O, Matthews Philippa C, Carrington Mary, Goulder Philip J R (2017), HLA-B*14:02-RESTRICTED ENV-SPECIFIC CD8+ T-CELL ACTIVITY HAS HIGHLY POTENT ANTIVIRAL EFFICACY ASSOCIATED WITH IMMUNE CONTROL OF HIV INFECTION., in Journal of virology, 1-1.
Ethnicity predicts viral rebound after travel to the tropics in HIV-infected travelers to the tropics in the Swiss HIV Cohort Study
Gebreselassie HM, Kraus D, Fux CA, Haubitz S, Scherrer A, Hatz C, Veit O, Stoeckle M, Fehr J, de Lucia S, Cavassini M, Bernasconi E, Schmid P, Furrer H, Staehelin C (2017), Ethnicity predicts viral rebound after travel to the tropics in HIV-infected travelers to the tropics in the Swiss HIV Cohort Study, in HIV Medicine, (8), 564-572.
Adverse events of raltegravir and dolutegravir.
Elzi Luigia, Erb Stefan, Furrer Hansjakob, Cavassini Matthias, Calmy Alexandra, Vernazza Pietro, Günthard Huldrych, Bernasconi Enos, Battegay Manuel, Swiss HIV Cohort Study Group (2017), Adverse events of raltegravir and dolutegravir., in AIDS (London, England), 31(13), 1853-1858.
HIV-infected patients' beliefs about their chronic co-treatments in comparison with their combined antiretroviral therapy.
Kamal S, Bugnon O, Cavassini M, Schneider M P (2017), HIV-infected patients' beliefs about their chronic co-treatments in comparison with their combined antiretroviral therapy., in HIV medicine, 1-1.
Impact of screening and antiretroviral therapy on anal cancer incidence in HIV-positive MSM
Blaser Nello, Bertisch Barbara, Kouyos Roger D., Calmy Alexandra, Bucher Heiner C., Cavassini Matthias, Estill Janne, Keiser Olivia, Egger Matthias (2017), Impact of screening and antiretroviral therapy on anal cancer incidence in HIV-positive MSM, in AIDS, 31(13), 1859-1866.
Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies
Trickey Adam, May Margaret T, Vehreschild Jorg-Janne, Obel Niels, Gill M John, Crane Heidi M, Boesecke Christoph, Patterson Sophie, Grabar Sophie, Cazanave Charles, Cavassini Matthias, Shepherd Leah, Monforte Antonella d'Arminio, van Sighem Ard, Saag Mike, Lampe Fiona, Hernando Vicky, Montero Marta, Zangerle Robert, Justice Amy C, Sterling Timothy, Ingle Suzanne M, Sterne Jonathan A C (2017), Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies, in The Lancet HIV, 4(8), e349-e356.
Immunological and virological response to antiretroviral treatment in migrant and native men and women in Western Europe; is benefit equal for all?
Migrant Health Working Group for the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord (2017), Immunological and virological response to antiretroviral treatment in migrant and native men and women in Western Europe; is benefit equal for all?, in HIV medicine, 1-1.
Trends in HCV treatment uptake, efficacy and impact on liver fibrosis in the Swiss HIV Cohort Study.
Béguelin Charles, Suter Annatina, Bernasconi Enos, Fehr Jan, Kovari Helen, Bucher Heiner C, Stoeckle Marcel, Cavassini Mathias, Rougemont Mathieu, Schmid Patrick, Wandeler Gilles, Rauch Andri, Swiss HIV Cohort Study (2017), Trends in HCV treatment uptake, efficacy and impact on liver fibrosis in the Swiss HIV Cohort Study., in Liver international : official journal of the International Association for the Study of the Liver, 1-1.
High levels of post-migration HIV acquisition within nine European countries.
Alvarez-Del Arco Debora, Fakoya Ibidun, Thomadakis Christos, Pantazis Nikos, Touloumi Giota, Gennotte Anne-Francoise, Zuure Freke, Barros Henrique, Staehelin Cornelia, Göpel Siri, Boesecke Christoph, Prestileo Tullio, Volny-Anne Alain, Burns Fiona, Del Amo Julia, aMASE (Advancing Migrant Access to Health Services in Europe) study team (2017), High levels of post-migration HIV acquisition within nine European countries., in AIDS (London, England).
On the potential of a short-term intensive intervention to interrupt HCV transmission in HIV-positive men who have sex with men: A mathematical modelling study.
Salazar-Vizcaya L, Kouyos R D, Fehr J, Braun D, Estill J, Bernasconi E, Delaloye J, Stöckle M, Schmid P, Rougemont M, Wandeler G, Günthard H F, Keiser O, Rauch A, Rauch A (2017), On the potential of a short-term intensive intervention to interrupt HCV transmission in HIV-positive men who have sex with men: A mathematical modelling study., in Journal of viral hepatitis, 1-1.
Rilpivirine use in the Swiss HIV cohort study: a prospective cohort study.
Sculier Delphine, Gayet-Ageron Angèle, Battegay Manuel, Cavassini Matthias, Fehr Jan, Hirzel Cedric, Schmid Patrick, Bernasconi Enos, Calmy Alexandra, Calmy Alexandra (2017), Rilpivirine use in the Swiss HIV cohort study: a prospective cohort study., in BMC infectious diseases, 17(1), 476-476.
Differentiated Human Immunodeficiency Virus RNA Monitoring in Resource-Limited Settings: An Economic Analysis
Negoescu Diana M., Zhang Zhenhuan, Bucher Heiner C., Bendavid Eran (2017), Differentiated Human Immunodeficiency Virus RNA Monitoring in Resource-Limited Settings: An Economic Analysis, in Clinical Infectious Diseases, 64(12), 1724-1730.
Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe
Blanquart François, Wymant Chris, Cornelissen Marion, Gall Astrid, Bakker Margreet, Bezemer Daniela, Hall Matthew, Hillebregt Mariska, Ong Swee Hoe, Albert Jan, Bannert Norbert, Fellay Jacques, Fransen Katrien, Gourlay Annabelle J., Grabowski M. Kate, Gunsenheimer-Bartmeyer Barbara, Günthard Huldrych F., Kivelä Pia, Kouyos Roger, Laeyendecker Oliver, Liitsola Kirsi, Meyer Laurence, Porter Kholoud, Ristola Matti, et al. (2017), Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe, in PLOS Biology, 15(6), e2001855-e2001855.
Comparison of dynamic monitoring strategies based on CD4 cell counts in virally suppressed, HIV-positive individuals on combination antiretroviral therapy in high-income countries: a prospective, observational study
Caniglia Ellen C, Cain Lauren E, Sabin Caroline A, Robins James M, Logan Roger, Abgrall Sophie, Mugavero Michael J, Hernández-Díaz Sonia, Meyer Laurence, Seng Remonie, Drozd Daniel R, Seage George R, Bonnet Fabrice, Dabis Francois, Moore Richard D, Reiss Peter, van Sighem Ard, Mathews William C, del Amo Julia, Moreno Santiago, Deeks Steven G, Muga Roberto, Boswell Stephen L, Ferrer Elena, et al. (2017), Comparison of dynamic monitoring strategies based on CD4 cell counts in virally suppressed, HIV-positive individuals on combination antiretroviral therapy in high-income countries: a prospective, observational study, in The Lancet HIV, 4(6), e251-e259.
Impact of Tenofovir on Hepatitis Delta Virus Replication in the Swiss Human Immunodeficiency Virus Cohort Study.
Béguelin Charles, Friolet Nicole, Moradpour Darius, Sahli Roland, Suter-Riniker Franziska, Lüthi Alexander, Cavassini Matthias, Günthard Huldrych F, Battegay Manuel, Bernasconi Enos, Schmid Patrick, Calmy Alexandra, Atkinson Andrew, Rauch Andri, Wandeler Gilles, Swiss HIV Cohort Study (2017), Impact of Tenofovir on Hepatitis Delta Virus Replication in the Swiss Human Immunodeficiency Virus Cohort Study., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 64(9), 1275-1278.
Predictors of estimated glomerular filtration rate progression, stabilization or improvement after chronic renal impairment in HIV-positive individuals
Ryom Lene, Mocroft Amanda, Kirk Ole, Reiss Peter, Ross Michael, Smith Colette, Moranne Olivier, Morlat Philippe, Fux Christoph A., Sabin Caroline, Phillips Andrew, Law Matthew, Lundgren Jens D. (2017), Predictors of estimated glomerular filtration rate progression, stabilization or improvement after chronic renal impairment in HIV-positive individuals, in AIDS, 31(9), 1261-1270.
Changes in Cardiovascular Disease Risk Factors With Immediate Versus Deferred Antiretroviral Therapy Initiation Among HIV-Positive Participants in the START (Strategic Timing of Antiretroviral Treatment) Trial.
Baker Jason V, Sharma Shweta, Achhra Amit C, Bernardino Jose Ignacio, Bogner Johannes R, Duprez Daniel, Emery Sean, Gazzard Brian, Gordin Jonathan, Grandits Greg, Phillips Andrew N, Schwarze Siegfried, Soliman Elsayed Z, Spector Stephen A, Tambussi Giuseppe, Lundgren Jens, Lundgren Jens (2017), Changes in Cardiovascular Disease Risk Factors With Immediate Versus Deferred Antiretroviral Therapy Initiation Among HIV-Positive Participants in the START (Strategic Timing of Antiretroviral Treatment) Trial., in Journal of the American Heart Association, 6(5), 0-0.
Comparison of Kaposi sarcoma risk in HIV-positive adults across five continents: a multiregional multicohort study.
COHERE in EuroCoord, Bohlius Julia, AIDS-defining Cancer Project Working Group for IeDEA (2017), Comparison of Kaposi sarcoma risk in HIV-positive adults across five continents: a multiregional multicohort study., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
Antiretrovirals, Fractures, and Osteonecrosis in a Large International HIV Cohort
Borges Álvaro H., Hoy Jennifer, Florence Eric, Sedlacek Dalibor, Stellbrink Hans-Jürgen, Uzdaviniene Vilma, Tomazic Janez, Gargalianos-Kakolyris Panagiotis, Schmid Patrick, Orkin Chloe, Pedersen Court, Leen Clifford, Pradier Christian, Mulcahy Fiona, Ridolfo Anna Lisa, Staub Therese, Maltez Fernando, Weber Rainer, Flamholc Leo, Kyselyova Galina, Lundgren Jens D, Mocroft Amanda (2017), Antiretrovirals, Fractures, and Osteonecrosis in a Large International HIV Cohort, in Clinical Infectious Diseases, (10), 1413-1421.
Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters
Brandenberg Oliver F., Magnus Carsten, Rusert Peter, Günthard Huldrych F., Regoes Roland R., Trkola Alexandra (2017), Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters, in PLOS Pathogens, 13(5), e1006313-e1006313.
Impact of CD4 and CD8 dynamics and viral rebounds on loss of virological control in HIV controllers
Chereau Fanny, Madec Yoann, Sabin Caroline, Obel Niels, Ruiz-Mateos Ezequiel, Chrysos Georgios, Fidler Sarah, Lehmann Clara, Zangerle Robert, Wittkop Linda, Reiss Peter, Hamouda Osamah, Estrada Perez Vicente, Leal Manuel, Mocroft Amanda, Garcia De Olalla Patricia, Ammassari Adriana, D’Arminio Monforte Antonella, Mussini Cristina, Segura Ferran, Castagna Antonella, Cavassini Matthias, Grabar Sophie, Morlat Philippe, et al. (2017), Impact of CD4 and CD8 dynamics and viral rebounds on loss of virological control in HIV controllers, in PLOS ONE, 12(4), e0173893-e0173893.
Improved quality of life with immediate versus deferred initiation of antiretroviral therapy in early asymptomatic HIV infection
Lifson Alan R., Grund Birgit, Gardner Edward M., Kaplan Richard, Denning Eileen, Engen Nicole, Carey Catherine L., Chen Fabian, Dao Sounkalo, Florence Eric, Sanz Jesus, Emery Sean (2017), Improved quality of life with immediate versus deferred initiation of antiretroviral therapy in early asymptomatic HIV infection, in AIDS, 31(7), 953-963.
Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration
Rhee Soo-Yon, Varghese Vici, Holmes Susan P., Van Zyl Gert U., Steegen Kim, Boyd Mark A., Cooper David A., Nsanzimana Sabin, Saravanan Shanmugam, Charpentier Charlotte, de Oliveira Tulio, Etiebet Mary-Ann A., Garcia Federico, Goedhals Dominique, Gomes Perpetua, Günthard Huldrych F., Hamers Raph L., Hoffmann Christopher J, Hunt Gillian, Jiamsakul Awachana, Kaleebu Pontiano, Kanki Phyllis, Kantor Rami, Kerschberger Bernhard, et al. (2017), Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration, in EBioMedicine, 18, 225-235.
Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality
Beauparlant David, Rusert Peter, Magnus Carsten, Kadelka Claus, Weber Jacqueline, Uhr Therese, Zagordi Osvaldo, Oberle Corinna, Duenas-Decamp Maria J., Clapham Paul R., Metzner Karin J., Günthard Huldrych F., Trkola Alexandra (2017), Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality, in PLOS Pathogens, 13(3), e1006255-e1006255.
Effect of immediate initiation of antiretroviral therapy on risk of severe bacterial infections in HIV-positive people with CD4 cell counts of more than 500 cells per μL: secondary outcome results from a randomised controlled trial
O'Connor Jemma, Vjecha Michael J, Phillips Andrew N, Angus Brian, Cooper David, Grinsztejn Beatriz, Lopardo Gustavo, Das Satyajit, Wood Robin, Wilkin Aimee, Klinker Hartwig, Kantipong Pacharee, Klingman Karin L, Jilich David, Herieka Elbushra, Denning Eileen, Abubakar Ibrahim, Gordin Fred, Lundgren Jens D (2017), Effect of immediate initiation of antiretroviral therapy on risk of severe bacterial infections in HIV-positive people with CD4 cell counts of more than 500 cells per μL: secondary outcome results from a randomised controlled trial, in The Lancet HIV, 4(3), e105-e112.
Is response to anti–hepatitis C virus treatment predictive of mortality in hepatitis C virus/HIV-positive patients?
Peters Lars, The Hepatitis C Working Group for the Collaboration of Observational HIV Epidemiological Research Eu (2017), Is response to anti–hepatitis C virus treatment predictive of mortality in hepatitis C virus/HIV-positive patients?, in AIDS, 31(5), 661-668.
Timing of combined antiretroviral treatment initiation in male and female migrants living with HIV in Western Europe
Monge Susana, Migrant Health Working Group (2017), Timing of combined antiretroviral treatment initiation in male and female migrants living with HIV in Western Europe, in AIDS, 31(6), 835-846.
An epidemiological modelling study to estimate the composition of HIV-positive populations including migrants from endemic settings.
Nakagawa Fumiyo, Nakagawa Fumiyo (2017), An epidemiological modelling study to estimate the composition of HIV-positive populations including migrants from endemic settings., in AIDS (London, England), (3), 417-425.
Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control
Bartha István, McLaren Paul J., Brumme Chanson, Harrigan Richard, Telenti Amalio, Fellay Jacques (2017), Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control, in PLOS Computational Biology, 13(2), e1005339-e1005339.
Hepatitis delta-associated mortality in HIV/HBV-coinfected patients
Béguelin Charles, Moradpour Darius, Sahli Roland, Suter-Riniker Franziska, Lüthi Alexander, Cavassini Matthias, Günthard Huldrych F., Battegay Manuel, Bernasconi Enos, Schmid Patrick, Calmy Alexandra, Braun Dominique L., Furrer Hansjakob, Rauch Andri, Wandeler Gilles (2017), Hepatitis delta-associated mortality in HIV/HBV-coinfected patients, in Journal of Hepatology, (2), 297-303.
Human papillomavirus antibody response following HAART initiation among MSM
Combes Jean-Damien, Clifford Gary M., Egger Matthias, Cavassini Matthias, Hirsch Hans H., Hauser Christoph, Calmy Alexandra, Schmid Patrick, Bernasconi Enos, Günthard Huldrych F., Franceschi Silvia, Waterboer Tim, Scherrer Alexandra U. (2017), Human papillomavirus antibody response following HAART initiation among MSM, in AIDS, (4), 561-569.
Virological Blips and Predictors of Post Treatment Viral Control After Stopping ART Started in Primary HIV Infection
Fidler Sarah, Olson Ashley D., Bucher Heiner C., Fox Julie, Thornhill John, Morrison Charles, Muga Roberto, Phillips Andrew, Frater John, Porter Kholoud (2017), Virological Blips and Predictors of Post Treatment Viral Control After Stopping ART Started in Primary HIV Infection, in JAIDS Journal of Acquired Immune Deficiency Syndromes, 74(2), 126-133.
Plasma HIV-1 Tropism and the Risk of Short-Term Clinical Progression to AIDS or Death
Casadellà Maria, Cozzi-Lepri Alessandro, Phillips Andrew, Noguera-Julian Marc, Bickel Markus, Sedlacek Dalibor, Zilmer Kai, Clotet Bonaventura, Lundgren Jens D., Paredes Roger (2017), Plasma HIV-1 Tropism and the Risk of Short-Term Clinical Progression to AIDS or Death, in PLOS ONE, 12(1), e0166613-e0166613.
Therapeutic Immune Recovery and Reduction of CXCR4-Tropic HIV-1
Bader Joëlle, Däumer Martin, Schöni-Affolter Franziska, Böni Jürg, Gorgievski-Hrisoho Meri, Martinetti Gladys, Thielen Alexander, Klimkait Thomas (2017), Therapeutic Immune Recovery and Reduction of CXCR4-Tropic HIV-1, in Clinical Infectious Diseases, 64(3), 295-300.
Reference curves for CD4 T-cell count response to combination antiretroviral therapy in HIV-1-infected treatment-naïve patients
Bouteloup V, Sabin C, Mocroft A, Gras L, Pantazis N, Le Moing V, d'Arminio Monforte A, Mary-Krause M, Roca B, Miro JM, Battegay M, Brockmeyer N, Berenguer J, Morlat P, Obel N, De Wit S, Fätkenheuer G, Zangerle R, Ghosn J, Pérez-Hoyos S, Campbell M, Prins M, Chêne G, Meyer L, et al. (2017), Reference curves for CD4 T-cell count response to combination antiretroviral therapy in HIV-1-infected treatment-naïve patients, in HIV Medicine, 18(1), 33-44.
No Evidence for Association of β-Defensin Genomic Copy Number with HIV Susceptibility, HIV Load during Clinical Latency, or Progression to AIDSNo association of β-defensin copy number and HIV
Abujaber Razan, Shea Patrick R., McLaren Paul J., Lakhi Shabir, Gilmour Jill, Allen Susan, Fellay Jacques, Hollox Edward J. (2017), No Evidence for Association of β-Defensin Genomic Copy Number with HIV Susceptibility, HIV Load during Clinical Latency, or Progression to AIDSNo association of β-defensin copy number and HIV, in Annals of Human Genetics, 81(1), 27-34.
Chronic Hepatitis B and C Virus Infection and Risk for Non-Hodgkin Lymphoma in HIV-Infected PatientsA Cohort Study
Wang Qing, De Luca Andrea, Smith Colette, Zangerle Robert, Sambatakou Helen, Bonnet Fabrice, Smit Colette, Schommers Philipp, Thornton Alicia, Berenguer Juan, Peters Lars, Spagnuolo Vincenzo, Ammassari Adriana, Antinori Andrea, Quiros Roldan Eugenia, Mussini Cristina, Miro Jose M., Konopnicki Deborah, Fehr Jan, Campbell Maria A., Termote Monique, Bucher Heiner C. (2017), Chronic Hepatitis B and C Virus Infection and Risk for Non-Hodgkin Lymphoma in HIV-Infected PatientsA Cohort Study, in Annals of Internal Medicine, (1), 9-9.
Coinfection with HIV and hepatitis C virus in 229 children and young adults living in Europe
Thorne Claire, European Paediatric HIVHCV Co-infection Study Group (2017), Coinfection with HIV and hepatitis C virus in 229 children and young adults living in Europe, in AIDS, (1), 127-135.
Factors associated with syphilis incidence in the HIV-infected in the era of highly active antiretrovirals
Shilaih Mohaned, Marzel Alex, Braun Dominique L., Scherrer Alexandra U., Kovari Helen, Young Jim, Calmy Alexandra, Darling Katharine, Battegay Manuel, Hoffmann Matthias, Bernasconi Enos, Thurnheer Maria C., Günthard Huldrych F., Kouyos Roger D. (2017), Factors associated with syphilis incidence in the HIV-infected in the era of highly active antiretrovirals, in Medicine, 96(2), e5849-e5849.
Hepatitis C infection and the risk of non-liver-related morbidity and mortality in HIV-positive persons in the Swiss HIV Cohort Study.
Kovari Helen, Rauch Andri, Kouyos Roger, Rougemont Mathieu, Cavassini Matthias, Schmid Patrick, Stöckle Marcel, Bernasconi Enos, Weber Rainer, Ledergerber Bruno, Swiss HIV Cohort Study (2017), Hepatitis C infection and the risk of non-liver-related morbidity and mortality in HIV-positive persons in the Swiss HIV Cohort Study., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 0.
Inequalities by educational level in response to combination antiretroviral treatment and survival in HIV-positive men and women in Europe
Del Amo Julia, Socio-economic Inequalities and HIV Working Group (2017), Inequalities by educational level in response to combination antiretroviral treatment and survival in HIV-positive men and women in Europe, in AIDS, (2), 253-262.
High prevalence of physical inactivity among patients from the Swiss HIV Cohort Study
Schäfer Juliane, Young Jim, Calmy Alexandra, Nicca Dunja, Hasse Barbara, Brun del Re Claudia, Cavassini Matthias, Bernasconi Enos, Schmidt-Trucksäss Arno, Bucher Heiner C., Swiss HIV Cohort Study (2016), High prevalence of physical inactivity among patients from the Swiss HIV Cohort Study, in AIDS Care, (8), 1056-1061.
Impairment of CCR6 + and CXCR3 + Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization
Cecchinato Valentina, Bernasconi Enos, Speck Roberto F., Proietti Michele, Sauermann Ulrike, D’Agostino Gianluca, Danelon Gabriela, Rezzonico Jost Tanja, Grassi Fabio, Raeli Lorenzo, Schöni-Affolter Franziska, Stahl-Hennig Christiane, Uguccioni Mariagrazia, Swiss HIV Cohort Study (2016), Impairment of CCR6 + and CXCR3 + Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization, in The Journal of Immunology, 198(1), 184-195.
Cohort Profile: Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord.
Chêne Geneviève, Phillips Andrew, Costagliola Dominique, Sterne Jonathan A C, Furrer Hansjakob, Del Amo Julia, Mocroft Amanda, d'Arminio Monforte Antonella, Dabis François, Miro José M, Barger Diana, Termote Monique, Schwimmer Christine, Salbøl Brandt Rikke, Friis-Moller Nina, Raben Dorthe, Haerry David, Egger Matthias, Weller Ian, De Wit Stéphane (2016), Cohort Profile: Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord., in International journal of epidemiology, 1-1.
Efavirenz versus boosted atazanavir-containing regimens and immunologic, virologic, and clinical outcomesA prospective study of HIV-positive individuals
Cain Lauren E., Caniglia Ellen C., Phillips Andrew, Olson Ashley, Muga Roberto, Pérez-Hoyos Santiago, Abgrall Sophie, Costagliola Dominique, Rubio Rafael, Jarrín Inma, Bucher Heiner, Fehr Jan, van Sighem Ard, Reiss Peter, Dabis François, Vandenhende Marie-Anne, Logan Roger, Robins James, Sterne Jonathan A. C., Justice Amy, Tate Janet, Touloumi Giota, Paparizos Vasilis, Esteve Anna, et al. (2016), Efavirenz versus boosted atazanavir-containing regimens and immunologic, virologic, and clinical outcomesA prospective study of HIV-positive individuals, in Medicine, 95(41), e5133-e5133.
Can we believe the DAGs? A comment on the relationship between causal DAGs and mechanisms
Aalen OO, Røysland K, Gran JM, Kouyos R, Lange T (2016), Can we believe the DAGs? A comment on the relationship between causal DAGs and mechanisms, in Statistical Methods in Medical Research, 25(5), 2294-2314.
A Direct Comparison of Two Densely Sampled HIV Epidemics: The UK and Switzerland.
Ragonnet-Cronin Manon L, Shilaih Mohaned, Günthard Huldrych F, Hodcroft Emma B, Böni Jürg, Fearnhill Esther, Dunn David, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Yang Wan-Lin, Brown Alison E, Lycett Samantha J, Kouyos Roger, Brown Andrew J Leigh (2016), A Direct Comparison of Two Densely Sampled HIV Epidemics: The UK and Switzerland., in Scientific reports, 6, 32251-32251.
A Method to Estimate the Size and Characteristics of HIV-positive Populations Using an Individual-based Stochastic Simulation Model.
Nakagawa Fumiyo, van Sighem Ard, Thiebaut Rodolphe, Smith Colette, Ratmann Oliver, Cambiano Valentina, Albert Jan, Amato-Gauci Andrew, Bezemer Daniela, Campbell Colin, Commenges Daniel, Donoghoe Martin, Ford Deborah, Kouyos Roger, Lodwick Rebecca, Lundgren Jens, Pantazis Nikos, Pharris Anastasia, Quinten Chantal, Thorne Claire, Touloumi Giota, Delpech Valerie, Phillips Andrew, SSOPHIE project working group in EuroCoord (2016), A Method to Estimate the Size and Characteristics of HIV-positive Populations Using an Individual-based Stochastic Simulation Model., in Epidemiology (Cambridge, Mass.), 27(2), 247-56.
Ability to Work and Employment Rates in Human Immunodeficiency Virus (HIV)-1-Infected Individuals Receiving Combination Antiretroviral Therapy: The Swiss HIV Cohort Study.
Elzi Luigia, Conen Anna, Patzen Annalea, Fehr Jan, Cavassini Matthias, Calmy Alexandra, Schmid Patrick, Bernasconi Enos, Furrer Hansjakob, Battegay Manuel (2016), Ability to Work and Employment Rates in Human Immunodeficiency Virus (HIV)-1-Infected Individuals Receiving Combination Antiretroviral Therapy: The Swiss HIV Cohort Study., in Open forum infectious diseases, 3(1), 022-022.
An updated prediction model of the global risk of cardiovascular disease in HIV-positive persons: The Data-collection on Adverse Effects of Anti-HIV Drugs (D:A:D) study.
Friis-Møller Nina, Ryom Lene, Smith Colette, Weber Rainer, Reiss Peter, Dabis F, De Wit Stephane, Monforte Antonella D'Arminio, Kirk Ole, Fontas Eric, Sabin Caroline, Phillips Andrew, Lundgren Jens, Law Matthew, D:A:D study group (2016), An updated prediction model of the global risk of cardiovascular disease in HIV-positive persons: The Data-collection on Adverse Effects of Anti-HIV Drugs (D:A:D) study., in European journal of preventive cardiology, 23(2), 214-23.
Antiretroviral Drugs and Risk of Chronic Alanine Aminotransferase Elevation in Human Immunodeficiency Virus (HIV)-Monoinfected Persons: The Data Collection on Adverse Events of Anti-HIV Drugs Study.
Kovari Helen, Sabin Caroline A, Ledergerber Bruno, Ryom Lene, Reiss Peter, Law Matthew, Pradier Christian, Dabis Francois, d'Arminio Monforte Antonella, Smith Colette, de Wit Stephane, Kirk Ole, Lundgren Jens D, Weber Rainer (2016), Antiretroviral Drugs and Risk of Chronic Alanine Aminotransferase Elevation in Human Immunodeficiency Virus (HIV)-Monoinfected Persons: The Data Collection on Adverse Events of Anti-HIV Drugs Study., in Open forum infectious diseases, 3(1), 009-009.
Assessment of Overlap of Phylogenetic Transmission Clusters and Communities in Simple Sexual Contact Networks: Applications to HIV-1.
Villandre Luc, Stephens David A, Labbe Aurelie, Günthard Huldrych F, Kouyos Roger, Stadler Tanja, Swiss HIV Cohort Study (2016), Assessment of Overlap of Phylogenetic Transmission Clusters and Communities in Simple Sexual Contact Networks: Applications to HIV-1., in PloS one, 11(2), 0148459-0148459.
Cause-Specific Mortality in HIV-Positive Patients Who Survived Ten Years after Starting Antiretroviral Therapy.
Trickey Adam, May Margaret T, Vehreschild Janne, Obel Niels, Gill Michael John, Crane Heidi, Boesecke Christoph, Samji Hasina, Grabar Sophie, Cazanave Charles, Cavassini Matthias, Shepherd Leah, d'Arminio Monforte Antonella, Smit Colette, Saag Michael, Lampe Fiona, Hernando Vicky, Montero Marta, Zangerle Robert, Justice Amy C, Sterling Timothy, Miro Jose, Ingle Suzanne, Sterne Jonathan A C, Sterne Jonathan A C (2016), Cause-Specific Mortality in HIV-Positive Patients Who Survived Ten Years after Starting Antiretroviral Therapy., in PloS one, 11(8), 0160460-0160460.
CD4/CD8 ratio and CD8 counts predict CD4 response in HIV-1-infected drug naive and in patients on cART.
Sauter Rafael, Huang Ruizhu, Ledergerber Bruno, Battegay Manuel, Bernasconi Enos, Cavassini Matthias, Furrer Hansjakob, Hoffmann Matthias, Rougemont Mathieu, Günthard Huldrych F, Held Leonhard (2016), CD4/CD8 ratio and CD8 counts predict CD4 response in HIV-1-infected drug naive and in patients on cART., in Medicine, 95(42), 5094-5094.
Changing Incidence and Risk Factors for Kaposi Sarcoma by Time Since Starting Antiretroviral Therapy: Collaborative Analysis of 21 European Cohort Studies.
Cancer Project Working Group for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study in EuroCoord (2016), Changing Incidence and Risk Factors for Kaposi Sarcoma by Time Since Starting Antiretroviral Therapy: Collaborative Analysis of 21 European Cohort Studies., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 63(10), 1373-1379.
Contribution of APOBEC3G/F activity to the development of low-abundance drug-resistant human immunodeficiency virus type 1 variants.
Noguera-Julian M, Cozzi-Lepri A, Di Giallonardo F, Schuurman R, Däumer M, Aitken S, Ceccherini-Silberstein F, D'Arminio Monforte A, Geretti A M, Booth C L, Kaiser R, Michalik C, Jansen K, Masquelier B, Bellecave P, Kouyos R D, Castro E, Furrer H, Schultze A, Günthard H F, Brun-Vezinet F, Metzner K J, Paredes R, CHAIN Minority HIV-1 Variants Working group (2016), Contribution of APOBEC3G/F activity to the development of low-abundance drug-resistant human immunodeficiency virus type 1 variants., in Clinical microbiology and infection : the official publication of the European Society of Clinical M, 22(2), 191-200.
Contribution of Genetic Background and Clinical Risk Factors to Low-Trauma Fractures in Human Immunodeficiency Virus (HIV)-Positive Persons: The Swiss HIV Cohort Study.
Junier Thomas, Rotger Margalida, Biver Emmanuel, Ledergerber Bruno, Barceló Catalina, Bartha Istvan, Kovari Helen, Schmid Patrick, Fux Christoph, Bernasconi Enos, Brun Del Re Claudia, Weber Rainer, Fellay Jacques, Tarr Philip E (2016), Contribution of Genetic Background and Clinical Risk Factors to Low-Trauma Fractures in Human Immunodeficiency Virus (HIV)-Positive Persons: The Swiss HIV Cohort Study., in Open forum infectious diseases, 3(2), 101-101.
Correlating HIV tropism with immunological response under combination antiretroviral therapy.
Bader J, Schöni-Affolter F, Böni J, Gorgievski-Hrisoho M, Martinetti G, Battegay M, Klimkait T (2016), Correlating HIV tropism with immunological response under combination antiretroviral therapy., in HIV medicine, (8), 615-22.
Cumulative and current exposure to potentially nephrotoxic antiretrovirals and development of chronic kidney disease in HIV-positive individuals with a normal baseline estimated glomerular filtration rate: a prospective international cohort study.
Mocroft Amanda, Lundgren Jens D, Ross Michael, Fux Christoph A, Reiss Peter, Moranne Olivier, Morlat Philippe, Monforte Antonella d'Arminio, Kirk Ole, Ryom Lene, Ryom Lene (2016), Cumulative and current exposure to potentially nephrotoxic antiretrovirals and development of chronic kidney disease in HIV-positive individuals with a normal baseline estimated glomerular filtration rate: a prospective international cohort study., in The lancet. HIV, (1), 23-32.
Determinants of HIV-1 broadly neutralizing antibody induction.
Rusert Peter, Kouyos Roger D, Kadelka Claus, Ebner Hanna, Schanz Merle, Huber Michael, Braun Dominique L, Hozé Nathanael, Scherrer Alexandra, Magnus Carsten, Weber Jacqueline, Uhr Therese, Cippa Valentina, Thorball Christian W, Kuster Herbert, Cavassini Matthias, Bernasconi Enos, Hoffmann Matthias, Calmy Alexandra, Battegay Manuel, Rauch Andri, Yerly Sabine, Aubert Vincent, Klimkait Thomas, Böni Jürg (2016), Determinants of HIV-1 broadly neutralizing antibody induction., in Nature medicine, (11), 1260-1267.
Dually Active HIV/HBV Antiretrovirals as Protection Against Incident Hepatitis B Infections: Potential for Prophylaxis.
Shilaih Mohaned, Marzel Alex, Scherrer Alexandra U, Braun Dominique L, Kovari Helen, Rougemont Mathieu, Darling Katharine, Battegay Manuel, Hoffmann Matthias, Bernasconi Enos, Hirzel Cedric, Günthard Huldrych F, Kouyos Roger D (2016), Dually Active HIV/HBV Antiretrovirals as Protection Against Incident Hepatitis B Infections: Potential for Prophylaxis., in The Journal of infectious diseases, 214(4), 599-606.
Dynamic models for estimating the effect of HAART on CD4 in observational studies: Application to the Aquitaine Cohort and the Swiss HIV Cohort Study.
Prague Mélanie, Commenges Daniel, Gran Jon Michael, Ledergerber Bruno, Young Jim, Furrer Hansjakob, Thiébaut Rodolphe (2016), Dynamic models for estimating the effect of HAART on CD4 in observational studies: Application to the Aquitaine Cohort and the Swiss HIV Cohort Study., in Biometrics, 0.
Emergence of Acquired HIV-1 Drug Resistance Almost Stopped in Switzerland: A 15-Year Prospective Cohort Analysis.
Scherrer Alexandra U, von Wyl Viktor, Yang Wan-Lin, Kouyos Roger D, Böni Jürg, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Cavassini Matthias, Battegay Manuel, Furrer Hansjakob, Calmy Alexandra, Vernazza Pietro, Bernasconi Enos, Günthard Huldrych F (2016), Emergence of Acquired HIV-1 Drug Resistance Almost Stopped in Switzerland: A 15-Year Prospective Cohort Analysis., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, (10), 1310-7.
Genotypic Resistance Tests Sequences Reveal the Role of Marginalized Populations in HIV-1 Transmission in Switzerland.
Shilaih Mohaned, Marzel Alex, Yang Wan Lin, Scherrer Alexandra U, Schüpbach Jörg, Böni Jürg, Yerly Sabine, Hirsch Hans H, Aubert Vincent, Cavassini Matthias, Klimkait Thomas, Vernazza Pietro L, Bernasconi Enos, Furrer Hansjakob, Günthard Huldrych F, Kouyos Roger, Swiss HIV Cohort Study (2016), Genotypic Resistance Tests Sequences Reveal the Role of Marginalized Populations in HIV-1 Transmission in Switzerland., in Scientific reports, 6, 27580-27580.
Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre retrospective cohort study.
TenoRes Study Group (2016), Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre retrospective cohort study., in The Lancet. Infectious diseases, 16(5), 565-75.
Hepatitis C virus transmission among human immunodeficiency virus-infected men who have sex with men: Modeling the effect of behavioral and treatment interventions.
Salazar-Vizcaya Luisa, Kouyos Roger D, Zahnd Cindy, Wandeler Gilles, Battegay Manuel, Darling Katharine Elizabeth Anna, Bernasconi Enos, Calmy Alexandra, Vernazza Pietro, Furrer Hansjakob, Egger Matthias, Keiser Olivia, Rauch Andri (2016), Hepatitis C virus transmission among human immunodeficiency virus-infected men who have sex with men: Modeling the effect of behavioral and treatment interventions., in Hepatology (Baltimore, Md.), 64(6), 1856-1869.
Higher rates of triple-class virological failure in perinatally HIV-infected teenagers compared with heterosexually infected young adults in Europe.
Judd A, Lodwick R, Noguera-Julian A, Gibb D M, Butler K, Costagliola D, Sabin C, van Sighem A, Ledergerber B, Torti C, Mocroft A, Podzamczer D, Dorrucci M, De Wit S, Obel N, Dabis F, Cozzi-Lepri A, García F, Brockmeyer N H, Warszawski J, Gonzalez-Tome M I, Mussini C, Touloumi G, Zangerle R, Ghosn J (2016), Higher rates of triple-class virological failure in perinatally HIV-infected teenagers compared with heterosexually infected young adults in Europe., in HIV medicine, 0.
HIV-1 Transmission During Recent Infection and During Treatment Interruptions as Major Drivers of New Infections in the Swiss HIV Cohort Study.
Marzel Alex, Shilaih Mohaned, Yang Wan-Lin, Böni Jürg, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Braun Dominique L, Calmy Alexandra, Furrer Hansjakob, Cavassini Matthias, Battegay Manuel, Vernazza Pietro L, Bernasconi Enos, Günthard Huldrych F, Kouyos Roger D, Swiss HIV Cohort Study (2016), HIV-1 Transmission During Recent Infection and During Treatment Interruptions as Major Drivers of New Infections in the Swiss HIV Cohort Study., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 62(1), 115-22.
HIV-Positive-to-HIV-Positive Liver Transplantation.
Calmy A, van Delden C, Giostra E, Junet C, Rubbia Brandt L, Yerly S, Chave J-P, Samer C, Elkrief L, Vionnet J, Berney T, Swiss HIV and Swiss Transplant Cohort Studies (2016), HIV-Positive-to-HIV-Positive Liver Transplantation., in American Journal of Transplantation, 16(8), 2473-2478.
Identification of Siglec-1 null individuals infected with HIV-1.
Martinez-Picado Javier, McLaren Paul J, Erkizia Itziar, Martin Maureen P, Benet Susana, Rotger Margalida, Dalmau Judith, Ouchi Dan, Wolinsky Steven M, Penugonda Sudhir, Günthard Huldrych F, Fellay Jacques, Carrington Mary, Izquierdo-Useros Nuria, Telenti Amalio (2016), Identification of Siglec-1 null individuals infected with HIV-1., in Nature communications, 7, 12412-12412.
Immediate Antiretroviral Therapy Reduces Risk of Infection-Related Cancer During Early HIV Infection.
Borges Álvaro H, Neuhaus Jacqueline, Babiker Abdel G, Henry Keith, Jain Mamta K, Palfreeman Adrian, Mugyenyi Peter, Domingo Pere, Hoffmann Christian, Read Tim R H, Pujari Sanjay, Meulbroek Michael, Johnson Margaret, Wilkin Timothy, Mitsuyasu Ronald, INSIGHT START Study Group (2016), Immediate Antiretroviral Therapy Reduces Risk of Infection-Related Cancer During Early HIV Infection., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 63(12), 1668-1676.
Immune recovery in HIV-infected patients after Candida esophagitis is impaired despite long-term antiretroviral therapy.
Stuehler Claudia, Bernardini Claudia, Elzi Luigia, Stoeckle Marcel, Zimmerli Stefan, Furrer Hansjakob, Günthard Huldrych F, Leibundgut-Landmann Salomé, Battegay Manuel, Khanna Nina, Swiss HIV Cohort Study (2016), Immune recovery in HIV-infected patients after Candida esophagitis is impaired despite long-term antiretroviral therapy., in AIDS (London, England), 30(12), 1923-33.
Immunodeficiency and the risk of cervical intraepithelial neoplasia 2/3 and cervical cancer: A nested case-control study in the Swiss HIV cohort study.
Clifford Gary M, Franceschi Silvia, Keiser Olivia, Schöni-Affolter Franziska, Lise Mauro, Dehler Silvia, Levi Fabio, Mousavi Mohsen, Bouchardy Christine, Wolfensberger Aline, Darling Katharine E, Staehelin Cornelia, Bertisch Barbara, Kuenzli Esther, Bernasconi Enos, Pawlita Michael, Egger Matthias, Swiss HIV Cohort Study (2016), Immunodeficiency and the risk of cervical intraepithelial neoplasia 2/3 and cervical cancer: A nested case-control study in the Swiss HIV cohort study., in International journal of cancer, (7), 1732-40.
Improved darunavir genotypic mutation score predicting treatment response for patients infected with HIV-1 subtype B and non-subtype B receiving a salvage regimen.
De Luca Andrea, Flandre Philippe, Dunn David, Zazzi Maurizio, Wensing Annemarie, Santoro Maria Mercedes, Günthard Huldrych F, Wittkop Linda, Kordossis Theodoros, Garcia Federico, Castagna Antonella, Cozzi-Lepri Alessandro, Churchill Duncan, De Wit Stéphane, Brockmeyer Norbert H, Imaz Arkaitz, Mussini Cristina, Obel Niels, Perno Carlo Federico, Roca Bernardino, Reiss Peter, Schülter Eugen, Torti Carlo, van Sighem Ard, Zangerle Robert (2016), Improved darunavir genotypic mutation score predicting treatment response for patients infected with HIV-1 subtype B and non-subtype B receiving a salvage regimen., in The Journal of antimicrobial chemotherapy, (5), 1352-60.
Improvements over time in short-term mortality following myocardial infarction in HIV-positive individuals.
Hatleberg Camilla Ingrid, Ryom Lene, El-Sadr Wafaa, Smith Colette, Weber Rainer, Reiss Peter, Fontas Eric, Dabis Francois, Law Matthew, Monforte Antonella d'Arminio, De Wit Stephane, Mocroft Amanda, Phillips Andrew, Lundgren Jens D, Sabin Caroline, D:A:D Study Group (2016), Improvements over time in short-term mortality following myocardial infarction in HIV-positive individuals., in AIDS (London, England), 30(10), 1583-96.
In Vivo Profiling and Distribution of Known and Novel Phase I and Phase II Metabolites of Efavirenz in Plasma, Urine, and Cerebrospinal Fluid.
Aouri Manel, Barcelo Catalina, Ternon Béatrice, Cavassini Matthias, Anagnostopoulos Alexia, Yerly Sabine, Hugues Henry, Vernazza Pietro, Günthard Huldrych F, Buclin Thierry, Telenti Amalio, Rotger Margalida, Decosterd Laurent A, Swiss HIV Cohort Study (2016), In Vivo Profiling and Distribution of Known and Novel Phase I and Phase II Metabolites of Efavirenz in Plasma, Urine, and Cerebrospinal Fluid., in Drug metabolism and disposition: the biological fate of chemicals, 44(1), 151-61.
Infection-related and -unrelated malignancies, HIV and the aging population.
Shepherd L, Borges Áh, Ledergerber B, Domingo P, Castagna A, Rockstroh J, Knysz B, Tomazic J, Karpov I, Kirk O, Lundgren J, Mocroft A, EuroSIDA in EuroCOORD (2016), Infection-related and -unrelated malignancies, HIV and the aging population., in HIV medicine, (8), 590-600.
Interleukin 6 Is a Stronger Predictor of Clinical Events Than High-Sensitivity C-Reactive Protein or D-Dimer During HIV Infection.
Borges Álvaro H, O'Connor Jemma L, Phillips Andrew N, Neaton James D, Grund Birgit, Neuhaus Jacqueline, Vjecha Michael J, Calmy Alexandra, Koelsch Kersten K, Lundgren Jens D (2016), Interleukin 6 Is a Stronger Predictor of Clinical Events Than High-Sensitivity C-Reactive Protein or D-Dimer During HIV Infection., in The Journal of infectious diseases, 214(3), 408-16.
Is nelfinavir exposure associated with cancer incidence in HIV-positive individuals?
Boettiger David C, Sabin Caroline A, Grulich Andrew, Ryom Lene, Bonnet Fabrice, Reiss Peter, Monforte Antonella d'arminio, Kirk Ole, Phillips Andrew, Bower Mark, Fätkenheuer Gerd, Lundgren Jens D, Law Matthew (2016), Is nelfinavir exposure associated with cancer incidence in HIV-positive individuals?, in AIDS (London, England), 30(10), 1629-37.
Is there continued evidence for an association between abacavir usage and myocardial infarction risk in individuals with HIV? A cohort collaboration.
Sabin Caroline A, Reiss Peter, Ryom Lene, Phillips Andrew N, Weber Rainer, Law Matthew, Fontas Eric, Mocroft Amanda, de Wit Stephane, Smith Colette, Dabis Francois, d'Arminio Monforte Antonella, El-Sadr Wafaa, Lundgren Jens D (2016), Is there continued evidence for an association between abacavir usage and myocardial infarction risk in individuals with HIV? A cohort collaboration., in BMC medicine, 14, 61-61.
Kaposi Sarcoma Risk in HIV-Infected Children and Adolescents on Combination Antiretroviral Therapy From Sub-Saharan Africa, Europe, and Asia.
Pediatric AIDS-Defining Cancer Project Working Group for IeDEA Southern Africa TApHOD and COHERE in EuroCoord (2016), Kaposi Sarcoma Risk in HIV-Infected Children and Adolescents on Combination Antiretroviral Therapy From Sub-Saharan Africa, Europe, and Asia., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, (9), 1245-1253.
Large-scale inference of conjunctive Bayesian networks.
Montazeri Hesam, Kuipers Jack, Kouyos Roger, Böni Jürg, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Günthard Huldrych F, Beerenwinkel Niko, Beerenwinkel Niko (2016), Large-scale inference of conjunctive Bayesian networks., in Bioinformatics (Oxford, England), 32(17), 727-735.
Liver fibrosis in treatment-naïve HIV-infected and HIV/HBV co-infected patients: Zambia and Switzerland compared.
Wandeler Gilles, Mulenga Lloyd, Vinikoor Michael J, Kovari Helen, Battegay Manuel, Calmy Alexandra, Cavassini Matthias, Bernasconi Enos, Schmid Patrick, Bolton-Moore Carolyn, Sinkala Edford, Chi Benjamin H, Egger Matthias, Rauch Andri, Rauch Andri (2016), Liver fibrosis in treatment-naïve HIV-infected and HIV/HBV co-infected patients: Zambia and Switzerland compared., in International journal of infectious diseases : IJID : official publication of the International Soci, 97-102.
Longitudinal analysis of the associations between antiretroviral therapy, viraemia and immunosuppression with lipid levels: the D:A:D study.
Kamara David A, Smith Colette, Ryom Lene, Reiss Peter, Rickenbach Martin, Phillips Andrew, Mocroft Amanda, De Wit Stephan, Law Matthew, Monforte Antonella d'Arminio, Dabis Francois, Pradier Christian, Lundgren Jens D, Sabin Caroline (2016), Longitudinal analysis of the associations between antiretroviral therapy, viraemia and immunosuppression with lipid levels: the D:A:D study., in Antiviral therapy, (6), 495-506.
Modelling the impact of deferring HCV treatment on liver-related complications in HIV coinfected men who have sex with men.
Zahnd Cindy, Salazar-Vizcaya Luisa, Dufour Jean-François, Müllhaupt Beat, Wandeler Gilles, Kouyos Roger, Estill Janne, Bertisch Barbara, Rauch Andri, Keiser Olivia (2016), Modelling the impact of deferring HCV treatment on liver-related complications in HIV coinfected men who have sex with men., in Journal of hepatology, 65(1), 26-32.
Mortality According to CD4 Count at Start of Combination Antiretroviral Therapy Among HIV-infected Patients Followed for up to 15 Years After Start of Treatment: Collaborative Cohort Study.
May Margaret T, Vehreschild Jorg-Janne, Trickey Adam, Obel Niels, Reiss Peter, Bonnet Fabrice, Mary-Krause Murielle, Samji Hasina, Cavassini Matthias, Gill Michael John, Shepherd Leah C, Crane Heidi M, d'Arminio Monforte Antonella, Burkholder Greer A, Johnson Margaret M, Sobrino-Vegas Paz, Domingo Pere, Zangerle Robert, Justice Amy C, Sterling Timothy R, Miró José M, Sterne Jonathan A C, Antiretroviral Therapy Cohort Collaboration (ART-CC) (2016), Mortality According to CD4 Count at Start of Combination Antiretroviral Therapy Among HIV-infected Patients Followed for up to 15 Years After Start of Treatment: Collaborative Cohort Study., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 62(12), 1571-7.
Mortality of treated HIV-1 positive individuals according to viral subtype in Europe and Canada: collaborative cohort analysis.
Antiretroviral Therapy Cohort Collaboration (ART-CC) (2016), Mortality of treated HIV-1 positive individuals according to viral subtype in Europe and Canada: collaborative cohort analysis., in AIDS (London, England), 30(3), 503-13.
Population pharmacokinetic analysis of elvitegravir and cobicistat in HIV-1-infected individuals.
Barceló Catalina, Gaspar Frédéric, Aouri Manel, Panchaud Alice, Rotger Margalida, Guidi Monia, Cavassini Matthias, Buclin Thierry, Decosterd Laurent A, Csajka Chantal (2016), Population pharmacokinetic analysis of elvitegravir and cobicistat in HIV-1-infected individuals., in The Journal of antimicrobial chemotherapy, 71(7), 1933-42.
Postnatal retention in HIV care: insight from the Swiss HIV Cohort Study over a 15-year observational period.
Aebi-Popp K, Kouyos R, Bertisch B, Staehelin C, Rudin C, Hoesli I, Stoeckle M, Bernasconi E, Cavassini M, Grawe C, Lecompte T D, Rickenbach M, Thorne C, Martinez de Tejada B, Fehr J, Swiss Mother and Child HIV Cohort Study, Swiss HIV Cohort Study (2016), Postnatal retention in HIV care: insight from the Swiss HIV Cohort Study over a 15-year observational period., in HIV medicine, 17(4), 280-8.
Prevalence and effect of pre-treatment drug resistance on the virological response to antiretroviral treatment initiated in HIV-infected children - a EuroCoord-CHAIN-EPPICC joint project.
Ngo-Giang-Huong Nicole, Wittkop Linda, Judd Ali, Reiss Peter, Goetghebuer Tessa, Duiculescu Dan, Noguera-Julian Antoni, Marczynska Magdalena, Giacquinto Carlo, Ene Luminita, Ramos Jose T, Cellerai Cristina, Klimkait Thomas, Brichard Benedicte, Valerius Niels, Sabin Caroline, Teira Ramon, Obel Niels, Stephan Christoph, de Wit Stéphane, Thorne Claire, Gibb Diana, Schwimmer Christine, Campbell Maria Athena, Pillay Deenan (2016), Prevalence and effect of pre-treatment drug resistance on the virological response to antiretroviral treatment initiated in HIV-infected children - a EuroCoord-CHAIN-EPPICC joint project., in BMC infectious diseases, 16(1), 654-654.
Privacy-preserving genomic testing in the clinic: a model using HIV treatment.
McLaren Paul J, Raisaro Jean Louis, Aouri Manel, Rotger Margalida, Ayday Erman, Bartha István, Delgado Maria B, Vallet Yannick, Günthard Huldrych F, Cavassini Matthias, Furrer Hansjakob, Doco-Lecompte Thanh, Marzolini Catia, Schmid Patrick, Di Benedetto Caroline, Decosterd Laurent A, Fellay Jacques, Hubaux Jean-Pierre, Telenti Amalio (2016), Privacy-preserving genomic testing in the clinic: a model using HIV treatment., in Genetics in medicine : official journal of the American College of Medical Genetics, 18(8), 814-22.
Renal Impairment and Cardiovascular Disease in HIV-Positive Individuals: The D:A:D Study.
Ryom Lene, Lundgren Jens D, Ross Mike, Kirk Ole, Law Matthew, Morlat Philippe, Fontas Eric, Smit Colette, Fux Christoph A, Hatleberg Camilla I, de Wit Stéphane, Sabin Caroline A, Mocroft Amanda, Mocroft Amanda (2016), Renal Impairment and Cardiovascular Disease in HIV-Positive Individuals: The D:A:D Study., in The Journal of infectious diseases, 214(8), 1212-20.
Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia.
An Ping, Penugonda Sudhir, Thorball Christian W, Bartha Istvan, Goedert James J, Donfield Sharyne, Buchbinder Susan, Binns-Roemer Elizabeth, Kirk Gregory D, Zhang Wenyan, Fellay Jacques, Yu Xiao-Fang, Winkler Cheryl A (2016), Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia., in PLoS genetics, 12(3), 1005921-1005921.
Role of Gag mutations in PI resistance in the Swiss HIV cohort study: bystanders or contributors?
Kletenkov K, Hoffmann D, Böni J, Yerly S, Aubert V, Schöni-Affolter F, Struck D, Verheyen J, Klimkait T, Swiss HIV Cohort Study (2016), Role of Gag mutations in PI resistance in the Swiss HIV cohort study: bystanders or contributors?, in The Journal of antimicrobial chemotherapy, 72(3), 866-875.
Sexual Activity Without Condoms and Risk of HIV Transmission in Serodifferent Couples When the HIV-Positive Partner Is Using Suppressive Antiretroviral Therapy.
Rodger Alison J, Cambiano Valentina, Bruun Tina, Vernazza Pietro, Collins Simon, van Lunzen Jan, Corbelli Giulio Maria, Estrada Vicente, Geretti Anna Maria, Beloukas Apostolos, Asboe David, Viciana Pompeyo, Gutiérrez Félix, Clotet Bonaventura, Pradier Christian, Gerstoft Jan, Weber Rainer, Westling Katarina, Wandeler Gilles, Prins Jan M, Rieger Armin, Stoeckle Marcel, Kümmerle Tim, Bini Teresa, Ammassari Adriana (2016), Sexual Activity Without Condoms and Risk of HIV Transmission in Serodifferent Couples When the HIV-Positive Partner Is Using Suppressive Antiretroviral Therapy., in JAMA, 316(2), 171-81.
Short-term weight gain after antiretroviral therapy initiation and subsequent risk of cardiovascular disease and diabetes: the D:A:D study.
Achhra A C, Mocroft A, Reiss P, Sabin C, Ryom L, de Wit S, Smith C J, d'Arminio Monforte A, Phillips A, Weber R, Lundgren J, Law M G (2016), Short-term weight gain after antiretroviral therapy initiation and subsequent risk of cardiovascular disease and diabetes: the D:A:D study., in HIV medicine, 17(4), 255-68.
Standard Genotyping Overestimates Transmission of Mycobacterium tuberculosis among Immigrants in a Low-Incidence Country.
Stucki David, Ballif Marie, Egger Matthias, Furrer Hansjakob, Altpeter Ekkehardt, Battegay Manuel, Droz Sara, Bruderer Thomas, Coscolla Mireia, Borrell Sonia, Zürcher Kathrin, Janssens Jean-Paul, Calmy Alexandra, Mazza Stalder Jesica, Jaton Katia, Rieder Hans L, Pfyffer Gaby E, Siegrist Hans H, Hoffmann Matthias, Fehr Jan, Dolina Marisa, Frei Reno, Schrenzel Jacques, Böttger Erik C, Gagneux Sebastien (2016), Standard Genotyping Overestimates Transmission of Mycobacterium tuberculosis among Immigrants in a Low-Incidence Country., in Journal of clinical microbiology, 54(7), 1862-70.
Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study.
Scherrer Alexandra U, Yang Wan-Lin, Kouyos Roger D, Böni Jürg, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Cavassini Matthias, Battegay Manuel, Hauser Christoph, Calmy Alexandra, Schmid Patrick, Bernasconi Enos, Günthard Huldrych F (2016), Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study., in The Journal of infectious diseases, 214(3), 399-402.
Switching from a two-tablet regimen of tenofovir/emtricitabine and efavirenz to a one-tablet regimen may affect patients' perceptions and drug management.
Rotzinger A, Locatelli I, Bugnon O, Fayet Mello A, Parienti J-J, Cavassini M, Schneider M P (2016), Switching from a two-tablet regimen of tenofovir/emtricitabine and efavirenz to a one-tablet regimen may affect patients' perceptions and drug management., in HIV medicine, 17(5), 390-6.
The cardiovascular risk management for people living with HIV in Europe: how well are we doing?
Shahmanesh Maryam, Schultze Anna, Burns Fiona, Kirk Ole, Lundgren Jens, Mussini Cristina, Pedersen Court, De Wit Stephane, Kutsyna Galyna, Mocroft Amanda (2016), The cardiovascular risk management for people living with HIV in Europe: how well are we doing?, in AIDS (London, England), 30(16), 2505-2518.
The impact of transient combination antiretroviral treatment in early HIV infection on viral suppression and immunologic response in later treatment.
Pantazis Nikos, Touloumi Giota, Meyer Laurence, Olson Ashley, Costagliola Dominique, Kelleher Anthony D, Lutsar Irja, Chaix Marie-Laure, Fisher Martin, Moreno Santiago, Porter Kholoud, CASCADE Collaboration in EuroCoord (2016), The impact of transient combination antiretroviral treatment in early HIV infection on viral suppression and immunologic response in later treatment., in AIDS (London, England), 30(6), 879-88.
The J-Curve in HIV: Low and Moderate Alcohol Intake Predicts Mortality but Not the Occurrence of Major Cardiovascular Events.
Wandeler Gilles, Kraus David, Fehr Jan, Conen Anna, Calmy Alexandra, Orasch Christina, Battegay Manuel, Schmid Patrick, Bernasconi Enos, Furrer Hansjakob, Swiss HIV Cohort Study (2016), The J-Curve in HIV: Low and Moderate Alcohol Intake Predicts Mortality but Not the Occurrence of Major Cardiovascular Events., in Journal of acquired immune deficiency syndromes (1999), 71(3), 302-9.
Tracing HIV-1 transmission: envelope traits of HIV-1 transmitter and recipient pairs.
Oberle Corinna S, Joos Beda, Rusert Peter, Campbell Nottania K, Beauparlant David, Kuster Herbert, Weber Jacqueline, Schenkel Corinne D, Scherrer Alexandra U, Magnus Carsten, Kouyos Roger, Rieder Philip, Niederöst Barbara, Braun Dominique L, Pavlovic Jovan, Böni Jürg, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Trkola Alexandra, Metzner Karin J, Günthard Huldrych F, Swiss HIV Cohort Study (SHCS) (2016), Tracing HIV-1 transmission: envelope traits of HIV-1 transmitter and recipient pairs., in Retrovirology, 13(1), 62-62.
Trends in Incidences and Risk Factors for Hepatocellular Carcinoma and Other Liver Events in HIV and Hepatitis C Virus-coinfected Individuals From 2001 to 2014: A Multicohort Study.
Gjærde Lars I, Shepherd Leah, Jablonowska Elzbieta, Lazzarin Adriano, Rougemont Mathieu, Darling Katharine, Battegay Manuel, Braun Dominique, Martel-Laferriere Valerie, Lundgren Jens D, Rockstroh Jürgen K, Gill John, Rauch Andri, Mocroft Amanda, Klein Marina B, Peters Lars (2016), Trends in Incidences and Risk Factors for Hepatocellular Carcinoma and Other Liver Events in HIV and Hepatitis C Virus-coinfected Individuals From 2001 to 2014: A Multicohort Study., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 63(6), 821-9.
Tuberculosis-related mortality in people living with HIV in Europe and Latin America: an international cohort study.
Podlekareva Daria N, Efsen Anne Marie W, Schultze Anna, Post Frank A, Skrahina Alena M, Panteleev Alexander, Furrer Hansjakob, Miller Robert F, Losso Marcelo H, Toibaro Javier, Miro Jose M, Vassilenko Anna, Girardi Enrico, Bruyand Mathias, Obel Niels, Lundgren Jens D, Mocroft Amanda, Kirk Ole (2016), Tuberculosis-related mortality in people living with HIV in Europe and Latin America: an international cohort study., in The lancet. HIV, 3(3), 120-31.
Use of antiretroviral therapy and risk of end-stage liver disease and hepatocellular carcinoma in HIV-positive persons.
Ryom Lene, Lundgren Jens Dilling, De Wit Stéphane, Kovari Helen, Reiss Peter, Law Matthew, El-Sadr Wafa, Monforte Antonella D'Arminio, Mocroft Amanda, Smith Colette, Fontas Eric, Dabis Francois, Phillips Andrew, Sabin Caroline, D:A:D Study Group (2016), Use of antiretroviral therapy and risk of end-stage liver disease and hepatocellular carcinoma in HIV-positive persons., in AIDS (London, England), 30(11), 1731-43.
When to Monitor CD4 Cell Count and HIV RNA to Reduce Mortality and AIDS-Defining Illness in Virologically Suppressed HIV-Positive Persons on Antiretroviral Therapy in High-Income Countries: A Prospective Observational Study.
Caniglia Ellen C, Sabin Caroline, Robins James M, Logan Roger, Cain Lauren E, Abgrall Sophie, Mugavero Michael J, Hernandez-Diaz Sonia, Meyer Laurence, Seng Remonie, Drozd Daniel R, Seage George R, Bonnet Fabrice, Dabis Francois, Moore Richard R, Reiss Peter, van Sighem Ard, Mathews William C, Del Amo Julia, Moreno Santiago, Deeks Steven G, Muga Roberto, Boswell Stephen L, Ferrer Elena, Eron Joseph J (2016), When to Monitor CD4 Cell Count and HIV RNA to Reduce Mortality and AIDS-Defining Illness in Virologically Suppressed HIV-Positive Persons on Antiretroviral Therapy in High-Income Countries: A Prospective Observational Study., in Journal of acquired immune deficiency syndromes (1999), 72(2), 214-21.
Injection Drug Use and Hepatitis C as Risk Factors for Mortality in HIV-Infected IndividualsThe Antiretroviral Therapy Cohort Collaboration
May Margaret T., Justice Amy C., Birnie Kate, Ingle Suzanne M., Smit Colette, Smith Colette, Neau Didier, Guiguet Marguerite, Schwarze-Zander Carolynne, Moreno Santiago, Guest Jodie L., Monforte Antonella dArminio, Tural Cristina, Gill Michael J., Bregenzer Andrea, Kirk Ole, Saag Michael, Sterling Timothy R., Crane Heidi M., Sterne Jonathan A. C. (2015), Injection Drug Use and Hepatitis C as Risk Factors for Mortality in HIV-Infected IndividualsThe Antiretroviral Therapy Cohort Collaboration, in JAIDS Journal of Acquired Immune Deficiency Syndromes, 69(3), 348-354.
A diagnostic HIV-1 tropism system based on sequence relatedness.
Edwards Suzanne, Stucki Heinz, Bader Joëlle, Vidal Vincent, Kaiser Rolf, Battegay Manuel, Klimkait Thomas (2015), A diagnostic HIV-1 tropism system based on sequence relatedness., in Journal of clinical microbiology, 53(2), 597-610.
A Lead-In with Silibinin Prior to Triple-Therapy Translates into Favorable Treatment Outcomes in Difficult-To-Treat HIV/Hepatitis C Coinfected Patients.
Braun Dominique L, Rauch Andri, Aouri Manel, Durisch Nina, Eberhard Nadia, Anagnostopoulos Alexia, Ledergerber Bruno, Müllhaupt Beat, Metzner Karin J, Decosterd Laurent, Böni Jürg, Weber Rainer, Fehr Jan (2015), A Lead-In with Silibinin Prior to Triple-Therapy Translates into Favorable Treatment Outcomes in Difficult-To-Treat HIV/Hepatitis C Coinfected Patients., in PloS one, 10(7), 0133028-0133028.
Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection.
Fitzmaurice Karen, Hurst Jacob, Dring Megan, Rauch Andri, McLaren Paul J, Günthard Huldrych F, Gardiner Clair, Klenerman Paul (2015), Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection., in Gut, 64(5), 813-9.
Algorithm evolution for drug resistance prediction: comparison of systems for HIV-1 genotyping.
Wagner Sarah, Kurz Mario, Klimkait Thomas, Swiss HIV Cohort Study (2015), Algorithm evolution for drug resistance prediction: comparison of systems for HIV-1 genotyping., in Antiviral therapy, 20(6), 661-5.
Assessing efficacy of different nucleos(t)ide backbones in NNRTI-containing regimens in the Swiss HIV Cohort Study.
Yang Wan-Lin, Kouyos Roger D, Scherrer Alexandra U, Böni Jürg, Shah Cyril, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Hirzel Cédric, Battegay Manuel, Cavassini Matthias, Bernasconi Enos, Vernazza Pietro, Held Leonhard, Ledergerber Bruno, Günthard Huldrych F, Swiss HIV Cohort Study (SHCS) (2015), Assessing efficacy of different nucleos(t)ide backbones in NNRTI-containing regimens in the Swiss HIV Cohort Study., in The Journal of antimicrobial chemotherapy, (12), 3323-31.
Assessing the Paradox Between Transmitted and Acquired HIV Type 1 Drug Resistance Mutations in the Swiss HIV Cohort Study From 1998 to 2012.
Yang Wan-Lin, Kouyos Roger, Scherrer Alexandra U, Böni Jürg, Shah Cyril, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Furrer Hansjakob, Battegay Manuel, Cavassini Matthias, Bernasconi Enos, Vernazza Pietro, Held Leonhard, Ledergerber Bruno, Günthard Huldrych F (2015), Assessing the Paradox Between Transmitted and Acquired HIV Type 1 Drug Resistance Mutations in the Swiss HIV Cohort Study From 1998 to 2012., in The Journal of infectious diseases, (1), 28-38.
Boosted lopinavir- versus boosted atazanavir-containing regimens and immunologic, virologic, and clinical outcomes: a prospective study of HIV-infected individuals in high-income countries.
HIV-CAUSAL Collaboration, Cain Lauren E, Phillips Andrew, Olson Ashley, Sabin Caroline, Jose Sophie, Justice Amy, Tate Janet, Logan Roger, Robins James M, Sterne Jonathan A C, van Sighem Ard, Reiss Peter, Young James, Fehr Jan, Touloumi Giota, Paparizos Vasilis, Esteve Anna, Casabona Jordi, Monge Susana, Moreno Santiago, Seng Rémonie, Meyer Laurence, Pérez-Hoyos Santiago, Muga Roberto (2015), Boosted lopinavir- versus boosted atazanavir-containing regimens and immunologic, virologic, and clinical outcomes: a prospective study of HIV-infected individuals in high-income countries., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 60(8), 1262-8.
Cancer risk and use of protease inhibitor or nonnucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy: the D: A: D study.
Bruyand Mathias, Ryom Lene, Shepherd Leah, Fatkenheuer Gerd, Grulich Andrew, Reiss Peter, de Wit Stéphane, D Arminio Monforte Antonella, Furrer Hansjakob, Pradier Christian, Lundgren Jens, Sabin Caroline (2015), Cancer risk and use of protease inhibitor or nonnucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy: the D: A: D study., in Journal of acquired immune deficiency syndromes (1999), 68(5), 568-77.
Changing utilization of Stavudine (d4T) in HIV-positive people in 2006-2013 in the EuroSIDA study.
Podlekareva D, Grint D, Karpov I, Rakmanova A, Mansinho K, Chentsova N, Zeltina I, Losso M, Parczewski M, Lundgren J D, Mocroft A, Kirk O (2015), Changing utilization of Stavudine (d4T) in HIV-positive people in 2006-2013 in the EuroSIDA study., in HIV medicine, (9), 533-43.
Comparative effectiveness of immediate antiretroviral therapy versus CD4-based initiation in HIV-positive individuals in high-income countries: observational cohort study.
Lodi Sara, Phillips Andrew, Logan Roger, Olson Ashley, Costagliola Dominique, Abgrall Sophie, van Sighem Ard, Reiss Peter, Miró José M, Ferrer Elena, Justice Amy, Gandhi Neel, Bucher Heiner C, Furrer Hansjakob, Moreno Santiago, Monge Susana, Touloumi Giota, Pantazis Nikos, Sterne Jonathan, Young Jessica G, Meyer Laurence, Seng Rémonie, Dabis Francois, Vandehende Marie-Anne, Pérez-Hoyos Santiago (2015), Comparative effectiveness of immediate antiretroviral therapy versus CD4-based initiation in HIV-positive individuals in high-income countries: observational cohort study., in The lancet. HIV, 2(8), 335-43.
Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study.
Mocroft Amanda, Lundgren Jens D, Ross Michael, Law Matthew, Reiss Peter, Kirk Ole, Smith Colette, Wentworth Deborah, Neuhaus Jacqueline, Fux Christoph A, Moranne Olivier, Morlat Phillipe, Johnson Margaret A, Ryom Lene, D:A:D study group, Royal Free Hospital Clinic Cohort, INSIGHT study group, SMART study group, ESPRIT study group (2015), Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study., in PLoS medicine, 12(3), 1001809-1001809.
Does rapid HIV disease progression prior to combination antiretroviral therapy hinder optimal CD4+ T-cell recovery once HIV-1 suppression is achieved?
Jarrin Inma, Pantazis Nikos, Dalmau Judith, Phillips Andrew N, Olson Ashley, Mussini Cristina, Boufassa Faroudy, Costagliola Dominique, Porter Kholoud, Blanco Juliá, Del Amo Julia, Martinez-Picado Javier (2015), Does rapid HIV disease progression prior to combination antiretroviral therapy hinder optimal CD4+ T-cell recovery once HIV-1 suppression is achieved?, in AIDS (London, England), 29(17), 2323-33.
Effect of abacavir on sustained virologic response to HCV treatment in HIV/HCV co-infected patients, Cohere in Eurocoord.
Hepatitis C- working group for COHERE in Eurocoord, Smit Colette, Arends Joop, Peters Lars, Montforte Antonella d'Arminio, Dabis Francois, Zangerle Robert, Daikos George, Mussini Christina, Mallolas Josep, de Wit Stephane, Zinkernagel Annelies, Cosin Jaime, Chene Genevieve, Raben Dorthe, Rockstroh Jürgen (2015), Effect of abacavir on sustained virologic response to HCV treatment in HIV/HCV co-infected patients, Cohere in Eurocoord., in BMC infectious diseases, 15, 498-498.
Effect of Cumulating Exposure to Abacavir on the Risk of Cardiovascular Disease Events in Patients From the Swiss HIV Cohort Study.
Young Jim, Xiao Yongling, Moodie Erica E M, Abrahamowicz Michal, Klein Marina B, Bernasconi Enos, Schmid Patrick, Calmy Alexandra, Cavassini Matthias, Cusini Alexia, Weber Rainer, Bucher Heiner C (2015), Effect of Cumulating Exposure to Abacavir on the Risk of Cardiovascular Disease Events in Patients From the Swiss HIV Cohort Study., in Journal of acquired immune deficiency syndromes (1999), 69(4), 413-21.
Efficacy of etravirine combined with darunavir or other ritonavir-boosted protease inhibitors in HIV-1-infected patients: an observational study using pooled European cohort data.
Vingerhoets J, Calvez V, Flandre P, Marcelin A-G, Ceccherini-Silberstein F, Perno C-F, Mercedes Santoro M, Bateson R, Nelson M, Cozzi-Lepri A, Grarup J, Lundgren J, Incardona F, Kaiser R, Sonnerborg A, Clotet B, Paredes R, Günthard H F, Ledergerber B, Hoogstoel A, Nijs S, Tambuyzer L, Lavreys L, Opsomer M, Opsomer M (2015), Efficacy of etravirine combined with darunavir or other ritonavir-boosted protease inhibitors in HIV-1-infected patients: an observational study using pooled European cohort data., in HIV medicine, (5), 297-306.
Estimating the dynamics and dependencies of accumulating mutations with applications to HIV drug resistance.
Montazeri Hesam, Günthard Huldrych F, Yang Wan-Lin, Kouyos Roger, Beerenwinkel Niko (2015), Estimating the dynamics and dependencies of accumulating mutations with applications to HIV drug resistance., in Biostatistics (Oxford, England), 16(4), 713-26.
Frequency of and Risk Factors for Depression among Participants in the Swiss HIV Cohort Study (SHCS).
Anagnostopoulos Alexia, Ledergerber Bruno, Jaccard René, Shaw Susy Ann, Stoeckle Marcel, Bernasconi Enos, Barth Jürgen, Calmy Alexandra, Berney Alexandre, Jenewein Josef, Weber Rainer (2015), Frequency of and Risk Factors for Depression among Participants in the Swiss HIV Cohort Study (SHCS)., in PloS one, 10(10), 0140943-0140943.
Gender inequalities in the response to combination antiretroviral therapy over time: the Swiss HIV Cohort Study.
Rosin C, Elzi L, Thurnheer C, Fehr J, Cavassini M, Calmy A, Schmid P, Bernasconi E, Battegay M (2015), Gender inequalities in the response to combination antiretroviral therapy over time: the Swiss HIV Cohort Study., in HIV medicine, 16(5), 319-25.
HBV genotypes and response to tenofovir disoproxil fumarate in HIV/HBV-coinfected persons.
Bihl Florian, Martinetti Gladys, Wandeler Gilles, Weber Rainer, Ledergeber Bruno, Calmy Alexandra, Battegay Manuel, Cavassini Matthias, Vernazza Pietro, Caminada Anna-Paola, Rickenbach Martin, Bernasconi Enos (2015), HBV genotypes and response to tenofovir disoproxil fumarate in HIV/HBV-coinfected persons., in BMC gastroenterology, 15, 79-79.
HCV treatment in children and young adults with HIV/HCV co-infection in Europe.
Turkova Anna, Giacomet Vania, Goetghebuer Tessa, Miloenko Milana, Nicolini Laura Ambra, Noguera-Julian Antoni, Rojo Pablo, Volokha Alla, Indolfi Giuseppe, Giaquinto Carlo, Thorne Claire (2015), HCV treatment in children and young adults with HIV/HCV co-infection in Europe., in Journal of virus eradication, 1(3), 179-84.
Hepatitis C seroconversions in HIV infection across Europe: which regions and patient groups are affected?
Boesecke Christoph, Grint Daniel, Soriano Vincent, Lundgren Jens D, d'Arminio Monforte Antonella, Mitsura Victor M, Chentsova Nelly, Hadziosmanovic Vesnadarjan, Kirk Ole, Mocroft Amanda, Peters Lars, Rockstroh Jürgen K, EuroSIDA in EuroCoord (2015), Hepatitis C seroconversions in HIV infection across Europe: which regions and patient groups are affected?, in Liver international : official journal of the International Association for the Study of the Liver, 35(11), 2384-91.
High hepatic and extrahepatic mortality and low treatment uptake in HCV-coinfected persons in the Swiss HIV cohort study between 2001 and 2013.
Kovari Helen, Ledergerber Bruno, Cavassini Matthias, Ambrosioni Juan, Bregenzer Andrea, Stöckle Marcel, Bernasconi Enos, Kouyos Roger, Weber Rainer, Rauch Andri, Swiss HIV Cohort Study (2015), High hepatic and extrahepatic mortality and low treatment uptake in HCV-coinfected persons in the Swiss HIV cohort study between 2001 and 2013., in Journal of hepatology, 63(3), 573-80.
HIV resistance testing and detected drug resistance in Europe.
Schultze Anna, Phillips Andrew N, Paredes Roger, Battegay Manuel, Rockstroh Jürgen K, Machala Ladislav, Tomazic Janez, Girard Pierre M, Januskevica Inga, Gronborg-Laut Kamilla, Lundgren Jens D, Cozzi-Lepri Alessandro, EuroSIDA in EuroCOORD (2015), HIV resistance testing and detected drug resistance in Europe., in AIDS (London, England), (11), 1379-89.
HIV-1 Drug Resistance and Second-Line Treatment in Children Randomized to Switch at Low Versus Higher RNA Thresholds.
Harrison Linda, Melvin Ann, Fiscus Susan, Saidi Yacine, Nastouli Eleni, Harper Lynda, Compagnucci Alexandra, Babiker Abdel, McKinney Ross, Gibb Diana, Tudor-Williams Gareth (2015), HIV-1 Drug Resistance and Second-Line Treatment in Children Randomized to Switch at Low Versus Higher RNA Thresholds., in Journal of acquired immune deficiency syndromes (1999), 70(1), 42-53.
Impact of body weight on virological and immunological responses to efavirenz-containing regimens in HIV-infected, treatment-naive adults.
Marzolini Catia, Sabin Caroline, Raffi François, Siccardi Marco, Mussini Cristina, Launay Odile, Burger David, Roca Bernardino, Fehr Jan, Bonora Stefano, Mocroft Amanda, Obel Niels, Dauchy Frederic-Antoine, Zangerle Robert, Gogos Charalambos, Gianotti Nicola, Ammassari Adriana, Torti Carlo, Ghosn Jade, Chêne Genevieve, Grarup Jesper, Battegay Manuel (2015), Impact of body weight on virological and immunological responses to efavirenz-containing regimens in HIV-infected, treatment-naive adults., in AIDS (London, England), (2), 193-200.
Impact of low-level viremia on clinical and virological outcomes in treated HIV-1-infected patients.
Antiretroviral Therapy Cohort Collaboration (ART-CC), Vandenhende Marie-Anne, Ingle Suzanne, May Margaret, Chene Geneviève, Zangerle Robert, Van Sighem Ard, Gill M John, Schwarze-Zander Carolynne, Hernandez-Novoa Beatriz, Obel Niels, Kirk Ole, Abgrall Sophie, Guest Jodie, Samji Hasina, D'Arminio Monforte Antonella, Llibre Josep M, Smith Colette, Cavassini Matthias, Burkholder Greer A, Shepherd Bryan, Crane Heidi M, Sterne Jonathan, Morlat Philippe (2015), Impact of low-level viremia on clinical and virological outcomes in treated HIV-1-infected patients., in AIDS (London, England), (3), 373-83.
Incident Hepatitis C Virus Infections in the Swiss HIV Cohort Study: Changes in Treatment Uptake and Outcomes Between 1991 and 2013.
Wandeler Gilles, Schlauri Marion, Jaquier Marie-Eve, Rohrbach Janine, Metzner Karin J, Fehr Jan, Ambrosioni Juan, Cavassini Matthias, Stöckle Marcel, Schmid Patrick, Bernasconi Enos, Keiser Olivia, Salazar-Vizcaya Luisa, Furrer Hansjakob, Rauch Andri, Rauch Andri, Aubert V, Battegay M, Bernasconi E, Böni J, Bucher H C, Burton-Jeangros C, Calmy A, Cavassini M, Dollenmaier G (2015), Incident Hepatitis C Virus Infections in the Swiss HIV Cohort Study: Changes in Treatment Uptake and Outcomes Between 1991 and 2013., in Open forum infectious diseases, 2(1), 026-026.
Increased mortality after a first myocardial infarction in human immunodeficiency virus-infected patients; a nested cohort study.
Carballo David, Delhumeau Cécile, Carballo Sebastian, Bähler Caroline, Radovanovic Dragona, Hirschel Bernard, Clerc Olivier, Bernasconi Enos, Fasel Dominique, Schmid Patrick, Cusini Alexia, Fehr Jan, Erne Paul, Keller Pierre-Fréderic, Ledergerber Bruno, Calmy Alexandra (2015), Increased mortality after a first myocardial infarction in human immunodeficiency virus-infected patients; a nested cohort study., in AIDS research and therapy, 12, 4-4.
Increases in Condomless Sex in the Swiss HIV Cohort Study.
Kouyos Roger D, Hasse Barbara, Calmy Alexandra, Cavassini Matthias, Furrer Hansjakob, Stöckle Marcel, Vernazza Pietro L, Bernasconi Enos, Weber Rainer, Günthard Huldrych F, Günthard Huldrych F, Aubert V, Battegay M, Bernasconi E, Böni J, Bucher H C, Burton-Jeangros C, Calmy A, Cavassini M, Dollenmaier G, Egger M, Elzi L, Fehr J, Fellay J, Furrer H (2015), Increases in Condomless Sex in the Swiss HIV Cohort Study., in Open forum infectious diseases, 2(2), 077-077.
Influence of noninjecting and injecting drug use on mortality, retention in the cohort, and antiretroviral therapy, in participants in the Swiss HIV Cohort Study.
Weber R, Huber M, Battegay M, Stähelin C, Castro Batanjer E, Calmy A, Bregenzer A, Bernasconi E, Schoeni-Affolter F, Ledergerber B, Swiss HIV Cohort Study (2015), Influence of noninjecting and injecting drug use on mortality, retention in the cohort, and antiretroviral therapy, in participants in the Swiss HIV Cohort Study., in HIV medicine, (3), 137-51.
Investigation of Efavirenz Discontinuation in Multi-ethnic Populations of HIV-positive Individuals by Genetic Analysis.
Cummins Nathan W, Neuhaus Jacqueline, Chu Haitao, Neaton James, Wyen Christoph, Rockstroh Jürgen K, Skiest Daniel J, Boyd Mark A, Khoo Saye, Rotger Margalida, Telenti Amalio, Weinshilboum Richard, Badley Andrew D, INSIGHT Study Group (2015), Investigation of Efavirenz Discontinuation in Multi-ethnic Populations of HIV-positive Individuals by Genetic Analysis., in EBioMedicine, 2(7), 706-12.
Kidney disease in antiretroviral-naïve HIV-positive adults with high CD4 counts: prevalence and predictors of kidney disease at enrolment in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial.
Achhra A C, Mocroft A, Ross M J, Ryom L, Lucas G M, Furrer H, Neuhaus J, Somboonwit C, Kelly M, Gatell J M, Wyatt C M, International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) START Study Group (2015), Kidney disease in antiretroviral-naïve HIV-positive adults with high CD4 counts: prevalence and predictors of kidney disease at enrolment in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial., in HIV medicine, 16 Suppl 1, 55-63.
Late presentation for HIV care across Europe: update from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study, 2010 to 2013.
Late presenters working group in COHERE in EuroCoord, Mocroft Amanda, Lundgren Jens, Antinori Andrea, Monforte Antonella d'Arminio, Brännström Johanna, Bonnet Fabrice, Brockmeyer Norbert, Casabona Jordi, Castagna Antonella, Costagliola Dominique, De Wit Stéphane, Fätkenheuer Gerd, Furrer Hansjakob, Jadand Corinne, Johnson Anne, Lazanas Mario, Leport Catherine, Moreno Santiago, Mussini Christina, Obel Niels, Post Frank, Reiss Peter, Sabin Caroline, Skaletz-Rorowski Adriane (2015), Late presentation for HIV care across Europe: update from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study, 2010 to 2013., in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable diseas, 20(47), 1560-1572.
Liver-related death among HIV/hepatitis C virus-co-infected individuals: implications for the era of directly acting antivirals.
Grint Daniel, Peters Lars, Rockstroh Juergen K, Rakmanova Aza, Trofimova Tatiana, Lacombe Karine, Karpov Igor, Galli Massimo, Domingo Pere, Kirk Ole, Lundgren Jens D, Mocroft Amanda, EuroSIDA in EuroCoord (2015), Liver-related death among HIV/hepatitis C virus-co-infected individuals: implications for the era of directly acting antivirals., in AIDS (London, England), 29(10), 1205-15.
Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: a multicohort European case-control study using centralized ultrasensitive 454 pyrosequencing.
Cozzi-Lepri Alessandro, Noguera-Julian Marc, Di Giallonardo Francesca, Schuurman Rob, Däumer Martin, Aitken Sue, Ceccherini-Silberstein Francesca, D'Arminio Monforte Antonella, Geretti Anna Maria, Booth Clare L, Kaiser Rolf, Michalik Claudia, Jansen Klaus, Masquelier Bernard, Bellecave Pantxika, Kouyos Roger D, Castro Erika, Furrer Hansjakob, Schultze Anna, Günthard Huldrych F, Brun-Vezinet Francoise, Paredes Roger, Metzner Karin J (2015), Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: a multicohort European case-control study using centralized ultrasensitive 454 pyrosequencing., in The Journal of antimicrobial chemotherapy, 70(3), 930-40.
Major Challenges in Clinical Management of TB/HIV Coinfected Patients in Eastern Europe Compared with Western Europe and Latin America.
Efsen Anne Marie W, Schultze Anna, Post Frank A, Panteleev Alexander, Furrer Hansjakob, Miller Robert F, Losso Marcelo H, Toibaro Javier, Skrahin Aliaksandr, Miro Jose M, Caylà Joan A, Girardi Enrico, Bruyand Mathias, Obel Niels, Podlekareva Daria N, Lundgren Jens D, Mocroft Amanda, Kirk Ole (2015), Major Challenges in Clinical Management of TB/HIV Coinfected Patients in Eastern Europe Compared with Western Europe and Latin America., in PloS one, 10(12), 0145380-0145380.
Major differences in organization and availability of health care and medicines for HIV/TB coinfected patients across Europe.
Mansfeld M, Skrahina A, Shepherd L, Schultze A, Panteleev A M, Miller R F, Miro J M, Zeltina I, Tetradov S, Furrer H, Kirk O, Grzeszczuk A, Bolokadze N, Matteelli A, Post F A, Lundgren J D, Mocroft A, Efsen Amw, Podlekareva D N, TB:HIV study group in EuroCoor (2015), Major differences in organization and availability of health care and medicines for HIV/TB coinfected patients across Europe., in HIV medicine, 16(9), 544-52.
Molecular Analyses Define Vα7.2-Jα33+ MAIT Cell Depletion in HIV Infection: A Case-Control Study.
Ussher James E, Phalora Prabhjeet, Cosgrove Cormac, Hannaway Rachel F, Rauch Andri, Günthard Huldrych F, Goulder Philip, Phillips Rodney E, Willberg Christian B, Klenerman Paul (2015), Molecular Analyses Define Vα7.2-Jα33+ MAIT Cell Depletion in HIV Infection: A Case-Control Study., in Medicine, 94(29), 1134-1134.
Mortality in migrants living with HIV in western Europe (1997-2013): a collaborative cohort study.
Migrants Working Group on behalf of COHERE in EuroCoord (2015), Mortality in migrants living with HIV in western Europe (1997-2013): a collaborative cohort study., in The lancet. HIV, 2(12), 540-9.
Neighbourhood socio-economic position, late presentation and outcomes in people living with HIV in Switzerland.
Gueler Aysel, Schoeni-Affolter Franziska, Moser André, Bertisch Barbara, Bucher Heiner C, Calmy Alexandra, Cavassini Matthias, Ledergerber Bruno, Wandeler Gilles, Egger Matthias (2015), Neighbourhood socio-economic position, late presentation and outcomes in people living with HIV in Switzerland., in AIDS (London, England), 29(2), 231-8.
Persistence of transmitted HIV-1 drug resistance mutations associated with fitness costs and viral genetic backgrounds.
Yang Wan-Lin, Kouyos Roger D, Böni Jürg, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Scherrer Alexandra U, Shilaih Mohaned, Hinkley Trevor, Petropoulos Christos, Bonhoeffer Sebastian, Günthard Huldrych F (2015), Persistence of transmitted HIV-1 drug resistance mutations associated with fitness costs and viral genetic backgrounds., in PLoS pathogens, 11(3), 1004722-1004722.
Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.
McLaren Paul J, Coulonges Cedric, Bartha István, Lenz Tobias L, Deutsch Aaron J, Bashirova Arman, Buchbinder Susan, Carrington Mary N, Cossarizza Andrea, Dalmau Judith, De Luca Andrea, Goedert James J, Gurdasani Deepti, Haas David W, Herbeck Joshua T, Johnson Eric O, Kirk Gregory D, Lambotte Olivier, Luo Ma, Mallal Simon, van Manen Daniëlle, Martinez-Picado Javier, Meyer Laurence, Miro José M, Mullins James I (2015), Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load., in Proceedings of the National Academy of Sciences of the United States of America, 112(47), 14658-63.
Predicting smoking cessation and its relapse in HIV-infected patients: the Swiss HIV Cohort Study.
Ledergerber B, Nicca D, Calmy A, Cavassini M, Furrer H, Battegay M, Bucher Hc, Schäfer J, Young J, Bernasconi E (2015), Predicting smoking cessation and its relapse in HIV-infected patients: the Swiss HIV Cohort Study., in HIV medicine, 16(1), 3-14.
Prognostic factors for advanced-stage human immunodeficiency virus-associated classical Hodgkin lymphoma treated with doxorubicin, bleomycin, vinblastine, and dacarbazine plus combined antiretroviral therapy: a multi-institutional retrospective study.
Castillo Jorge J, Bower Mark, Brühlmann Jérémy, Novak Urban, Furrer Hansjakob, Tanaka Paula Y, Besson Caroline, Montoto Silvia, Cwynarski Kate, Abramson Jeremy S, Dalia Samir, Bibas Michele, Connors Joseph M, Furman Michael, Nguyen Minh-Ly, Cooley Timothy P, Beltran Brady E, Collins Jaime A, Vose Julie M, Xicoy Blanca, Ribera Josep-Maria, cART Era Study Group (2015), Prognostic factors for advanced-stage human immunodeficiency virus-associated classical Hodgkin lymphoma treated with doxorubicin, bleomycin, vinblastine, and dacarbazine plus combined antiretroviral therapy: a multi-institutional retrospective study., in Cancer, 121(3), 423-31.
Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.
Schmid Patrick, Bregenzer Andrea, Huber Milo, Rauch Andri, Jochum Wolfram, Müllhaupt Beat, Vernazza Pietro, Opravil Milos, Weber Rainer, Swiss HIV Cohort Study (2015), Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy., in PloS one, 10(9), 0138838-0138838.
Protease inhibitors to treat hepatitis C in the Swiss HIV Cohort Study: high efficacy but low treatment uptake.
Schaerer V, Haubitz S, Kovari H, Ledergerber B, Ambrosioni J, Cavassini M, Stoeckle M, Schmid P, Decosterd L, Aouri M, Böni J, Günthard H F, Furrer H, Metzner K J, Fehr J, Rauch A, Rauch A (2015), Protease inhibitors to treat hepatitis C in the Swiss HIV Cohort Study: high efficacy but low treatment uptake., in HIV medicine, 16(10), 599-607.
Reasons for late presentation to HIV care in Switzerland.
Hachfeld Anna, Ledergerber Bruno, Darling Katharine, Weber Rainer, Calmy Alexandra, Battegay Manuel, Sugimoto Kiyoshi, Di Benedetto Caroline, Fux Christoph A, Tarr Philip E, Kouyos Roger, Furrer Hansjakob, Wandeler Gilles (2015), Reasons for late presentation to HIV care in Switzerland., in Journal of the International AIDS Society, 18, 20317-20317.
Ribavirin Concentrations Do Not Predict Sustained Virological Response in HIV/HCV-Coinfected Patients Treated with Ribavirin and Pegylated Interferon in the Swiss HIV Cohort Study.
Kovari Helen, Russmann Stefan, Ledergerber Bruno, Müller Daniel, Rotger Margalida, Velli Pablo, Cavassini Matthias, Ambrosioni Juan, Bregenzer Andrea, Stöckle Marcel, Bernasconi Enos, Rauch Andri, Speck Roberto F, Swiss HIV Cohort Study (2015), Ribavirin Concentrations Do Not Predict Sustained Virological Response in HIV/HCV-Coinfected Patients Treated with Ribavirin and Pegylated Interferon in the Swiss HIV Cohort Study., in PloS one, 10(7), 0133879-0133879.
Self-reported nonadherence to antiretroviral therapy as a predictor of viral failure and mortality.
Glass Tracy R, Sterne Jonathan A C, Schneider Marie-Paule, De Geest Sabina, Nicca Dunja, Furrer Hansjakob, Günthard Huldrych F, Bernasconi Enos, Calmy Alexandra, Rickenbach Martin, Battegay Manuel, Bucher Heiner C (2015), Self-reported nonadherence to antiretroviral therapy as a predictor of viral failure and mortality., in AIDS (London, England), 29(16), 2195-200.
Sex differences in overall and cause-specific mortality among HIV-infected adults on antiretroviral therapy in Europe, Canada and the US.
Antiretroviral Therapy Cohort Collaboration (ART-CC) (2015), Sex differences in overall and cause-specific mortality among HIV-infected adults on antiretroviral therapy in Europe, Canada and the US., in Antiviral therapy, 20(1), 21-8.
Simultaneously estimating evolutionary history and repeated traits phylogenetic signal: applications to viral and host phenotypic evolution.
Vrancken Bram, Lemey Philippe, Rambaut Andrew, Bedford Trevor, Longdon Ben, Günthard Huldrych F, Suchard Marc A (2015), Simultaneously estimating evolutionary history and repeated traits phylogenetic signal: applications to viral and host phenotypic evolution., in Methods in ecology and evolution, 6(1), 67-82.
Smoking and life expectancy among HIV-infected individuals on antiretroviral therapy in Europe and North America
Helleberg Marie, May Margaret T., Ingle Suzanne M., Dabis Francois, Reiss Peter, Fätkenheuer Gerd, Costagliola Dominique, d’Arminio Antonella, Cavassini Matthias, Smith Colette, Justice Amy C., Gill John, Sterne Jonathan A.C., Obel Niels (2015), Smoking and life expectancy among HIV-infected individuals on antiretroviral therapy in Europe and North America, in AIDS, 29(2), 221-229.
Strong Impact of Smoking on Multimorbidity and Cardiovascular Risk Among Human Immunodeficiency Virus-Infected Individuals in Comparison With the General Population.
Hasse Barbara, Tarr Philip E, Marques-Vidal Pedro, Waeber Gerard, Preisig Martin, Mooser Vincent, Valeri Fabio, Djalali Sima, Andri Rauch, Bernasconi Enos, Calmy Alexandra, Cavassini Matthias, Vernazza Pietro, Battegay Manuel, Weber Rainer, Senn Oliver, Vollenweider Peter, Ledergerber Bruno, Ledergerber Bruno, Aubert V, Barth J, Battegay M, Bernasconi E, Böni J, Bucher H C (2015), Strong Impact of Smoking on Multimorbidity and Cardiovascular Risk Among Human Immunodeficiency Virus-Infected Individuals in Comparison With the General Population., in Open forum infectious diseases, 2(3), 108-108.
Switch to etravirine for HIV-positive patients receiving statin treatment: a prospective study.
Ciaffi Laura, Cavassini Matthias, Genne Daniel, Delhumeau Cecile, Spycher Elbes Rachel, Hill Andrew, Wandeler Gilles, Fehr Jan, Stoeckle Marcel, Schmid Patrick, Hirschel Bernard, Montecucco Fabrizio, Calmy Alexandra (2015), Switch to etravirine for HIV-positive patients receiving statin treatment: a prospective study., in European journal of clinical investigation, 45(7), 720-30.
The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome.
Bartha István, Rausell Antonio, McLaren Paul J, Mohammadi Pejman, Tardaguila Manuel, Chaturvedi Nimisha, Fellay Jacques, Telenti Amalio (2015), The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome., in PLoS computational biology, 11(12), 1004647-1004647.
The HIV care cascade in Switzerland: reaching the UNAIDS/WHO targets for patients diagnosed with HIV.
Kohler Philipp, Schmidt Axel J, Cavassini Matthias, Furrer Hansjakob, Calmy Alexandra, Battegay Manuel, Bernasconi Enos, Ledergerber Bruno, Vernazza Pietro (2015), The HIV care cascade in Switzerland: reaching the UNAIDS/WHO targets for patients diagnosed with HIV., in AIDS (London, England), 29(18), 2509-15.
The impact of vaccination on the breadth and magnitude of the antibody response to influenza A viruses in HIV-infected individuals.
Kohler Ines, Kouyos Roger, Bianchi Matteo, Grube Christina, Wyrzucki Arkadiusz, Günthard Huldrych F, Hangartner Lars (2015), The impact of vaccination on the breadth and magnitude of the antibody response to influenza A viruses in HIV-infected individuals., in AIDS (London, England), 29(14), 1803-10.
The Interplay Between Host Genetic Variation, Viral Replication, and Microbial Translocation in Untreated HIV-Infected Individuals.
Perkins Molly R, Bartha Istvan, Timmer J Katherina, Liebner Julia C, Wolinsky David, Wollinsky David, Günthard Huldrych F, Hauser Christoph, Bernasconi Enos, Hoffmann Matthias, Calmy Alexandra, Battegay Manuel, Telenti Amalio, Douek Daniel C, Fellay Jacques, Swiss HIV Cohort Study (2015), The Interplay Between Host Genetic Variation, Viral Replication, and Microbial Translocation in Untreated HIV-Infected Individuals., in The Journal of infectious diseases, 212(4), 578-84.
Tracking a tuberculosis outbreak over 21 years: strain-specific single-nucleotide polymorphism typing combined with targeted whole-genome sequencing.
Stucki David, Ballif Marie, Bodmer Thomas, Coscolla Mireia, Maurer Anne-Marie, Droz Sara, Butz Christa, Borrell Sonia, Längle Christel, Feldmann Julia, Furrer Hansjakob, Mordasini Carlo, Helbling Peter, Rieder Hans L, Egger Matthias, Gagneux Sébastien, Fenner Lukas (2015), Tracking a tuberculosis outbreak over 21 years: strain-specific single-nucleotide polymorphism typing combined with targeted whole-genome sequencing., in The Journal of infectious diseases, 211(8), 1306-16.
Transient detectable viremia and the risk of viral rebound in patients from the Swiss HIV Cohort Study.
Young Jim, Rickenbach Martin, Calmy Alexandra, Bernasconi Enos, Staehelin Cornelia, Schmid Patrick, Cavassini Matthias, Battegay Manuel, Günthard Huldrych F, Bucher Heiner C (2015), Transient detectable viremia and the risk of viral rebound in patients from the Swiss HIV Cohort Study., in BMC infectious diseases, 15, 382-382.
Using observational data to emulate a randomized trial of dynamic treatment-switching strategies: an application to antiretroviral therapy.
Cain Lauren E, Saag Michael S, Petersen Maya, May Margaret T, Ingle Suzanne M, Logan Roger, Robins James M, Abgrall Sophie, Shepherd Bryan E, Deeks Steven G, Gill M John, Touloumi Giota, Vourli Georgia, Dabis François, Vandenhende Marie-Anne, Reiss Peter, van Sighem Ard, Samji Hasina, Hogg Robert S, Rybniker Jan, Sabin Caroline A, Jose Sophie, Del Amo Julia, Moreno Santiago, Rodríguez Benigno (2015), Using observational data to emulate a randomized trial of dynamic treatment-switching strategies: an application to antiretroviral therapy., in International journal of epidemiology, 000-000.
Virological outcome and management of persistent low-level viraemia in HIV-1-infected patients: 11 years of the Swiss HIV Cohort Study.
Boillat-Blanco Noémie, Darling Katharine E A, Schoni-Affolter Franziska, Vuichard Danielle, Rougemont Mathieu, Fulchini Rosamaria, Bernasconi Enos, Aouri Manel, Clerc Olivier, Furrer Hansjakob, Günthard Huldrych F, Cavassini Matthias (2015), Virological outcome and management of persistent low-level viraemia in HIV-1-infected patients: 11 years of the Swiss HIV Cohort Study., in Antiviral therapy, 20(2), 165-75.
Vitamin D time profile based on the contribution of non-genetic and genetic factors in HIV-infected individuals of European ancestry.
Guidi Monia, Foletti Giuseppe, McLaren Paul, Cavassini Matthias, Rauch Andri, Tarr Philip E, Lamy Olivier, Panchaud Alice, Telenti Amalio, Csajka Chantal, Rotger Margalida (2015), Vitamin D time profile based on the contribution of non-genetic and genetic factors in HIV-infected individuals of European ancestry., in Antiviral therapy, 20(3), 261-9.
Thrombocytopenia is associated with an increased risk of cancer during treated HIV disease
Borges Álvaro H., Lundgren Jens D., Ridolfo Annalisa, Katlama Christine, Antunes Francisco, Grzeszczuk Anna, Blaxhult Anders, Mitsura Viktar M., Doroana Manuela, Battegay Manuel, Gargalianos Panagiotis, Mocroft Amanda (2014), Thrombocytopenia is associated with an increased risk of cancer during treated HIV disease, in AIDS, 28(17), 2565-2571.
Evaluation of Rapid Progressors in HIV Infection as an Extreme Phenotype
Olson Ashley D., Guiguet Marguerite, Zangerle Robert, Gill John, Perez-Hoyos Santiago, Lodi Sara, Ghosn Jade, Dorrucci Maria, Johnson Anne, Sannes Mette, Moreno Santiago, Porter Kholoud (2014), Evaluation of Rapid Progressors in HIV Infection as an Extreme Phenotype, in JAIDS Journal of Acquired Immune Deficiency Syndromes, 67(1), 15-21.
Deteriorating renal function and clinical outcomes in HIV-positive persons
Mocroft Amanda, Ryom Lene, Begovac Josip, Monforte Antonella D’Arminio, Vassilenko Anne, Gatell Jose, Florence Eric, Ormaasen Vidar, Kirk Ole, Lundgren Jens D. (2014), Deteriorating renal function and clinical outcomes in HIV-positive persons, in AIDS, 28(5), 727-737.
Increased incidence of antiretroviral drug discontinuation among patients with viremic hepatitis C virus coinfection and high hyaluronic acid, a marker of liver fibrosis
Grint Daniel, Peters Lars, Rockstroh Juergen K., de Wit Stephane, Mitsura Victor M., Knysz Brygida, Pedersen Court, Kirk Ole, Lundgren Jens D., Mocroft Amanda (2014), Increased incidence of antiretroviral drug discontinuation among patients with viremic hepatitis C virus coinfection and high hyaluronic acid, a marker of liver fibrosis, in AIDS, 28(4), 577-587.
Immuno-Virological Discordance and the Risk of Non-AIDS and AIDS Events in a Large Observational Cohort of HIV-Patients in Europe
Zoufaly Alexander, Cozzi-Lepri Alessandro, Reekie Joanne, Kirk Ole, Lundgren Jens, Reiss Peter, Jevtovic Djordje, Machala Ladislav, Zangerle Robert, Mocroft Amanda, Van Lunzen Jan (2014), Immuno-Virological Discordance and the Risk of Non-AIDS and AIDS Events in a Large Observational Cohort of HIV-Patients in Europe, in PLoS ONE, 9(1), e87160-e87160.
An Evaluation of HIV Elite Controller Definitions within a Large Seroconverter Cohort Collaboration
Olson Ashley D., Meyer Laurence, Prins Maria, Thiebaut Rodolphe, Gurdasani Deepti, Guiguet Marguerite, Chaix Marie-Laure, Amornkul Pauli, Babiker Abdel, Sandhu Manjinder S., Porter Kholoud (2014), An Evaluation of HIV Elite Controller Definitions within a Large Seroconverter Cohort Collaboration, in PLoS ONE, 9(1), e86719-e86719.
[Intracerebral HIV replication despite an efficient antiretroviral treatment: clinical impact and management].
Schibler M, Calmy A, Cavassini M, Du Pasquier R (2014), [Intracerebral HIV replication despite an efficient antiretroviral treatment: clinical impact and management]., in Revue medicale suisse, 10(427), 910-912.
A comparison of estimated glomerular filtration rates using Cockcroft-Gault and the Chronic Kidney Disease Epidemiology Collaboration estimating equations in HIV infection.
Mocroft A, Ryom L, Reiss P, Furrer H, D'Arminio Monforte A, Gatell J, de Wit S, Beniowski M, Lundgren J D, Kirk O (2014), A comparison of estimated glomerular filtration rates using Cockcroft-Gault and the Chronic Kidney Disease Epidemiology Collaboration estimating equations in HIV infection., in HIV medicine, 15(3), 144-52.
Accounting for baseline differences and measurement error in the analysis of change over time.
Braun Julia, Held Leonhard, Ledergerber Bruno, Swiss HIV Cohort Study (2014), Accounting for baseline differences and measurement error in the analysis of change over time., in Statistics in medicine, (1), 2-16.
Antiretroviral penetration into the CNS and incidence of AIDS-defining neurologic conditions.
Caniglia Ellen C, Cain Lauren E, Justice Amy, Tate Janet, Logan Roger, Sabin Caroline, Winston Alan, van Sighem Ard, Miro Jose M, Podzamczer Daniel, Olson Ashley, Arribas José Ramón, Moreno Santiago, Meyer Laurence, del Romero Jorge, Dabis François, Bucher Heiner C, Wandeler Gilles, Vourli Georgia, Skoutelis Athanasios, Lanoy Emilie, Gasnault Jacques, Costagliola Dominique, Hernán Miguel A (2014), Antiretroviral penetration into the CNS and incidence of AIDS-defining neurologic conditions., in Neurology, 83(2), 134-41.
Asking about adherence - from flipping the coin to strong evidence.
Glass Tracy, Cavassini Matthias (2014), Asking about adherence - from flipping the coin to strong evidence., in Swiss medical weekly, 144, 14016-14016.
Changes in biomarkers of liver disease during successful combination antiretroviral therapy in HIV-HCV-coinfected individuals.
Rohrbach Janine, Stickel Felix, Schmid Patrick, Thormann Wolfgang, Kovari Helen, Scherrer Alexandra, Günthard Huldrych F, Vuichard Danielle, Cavassini Matthias, Ambrosioni Juan, Bernasconi Enos, Furrer Hansjakob, Rauch Andri (2014), Changes in biomarkers of liver disease during successful combination antiretroviral therapy in HIV-HCV-coinfected individuals., in Antiviral therapy, 19(2), 149-59.
Clustering of HCV coinfections on HIV phylogeny indicates domestic and sexual transmission of HCV.
Kouyos Roger D, Rauch Andri, Böni Jürg, Yerly Sabine, Shah Cyril, Aubert Vincent, Klimkait Thomas, Kovari Helen, Calmy Alexandra, Cavassini Matthias, Battegay Manuel, Vernazza Pietro L, Bernasconi Enos, Ledergerber Bruno, Günthard Huldrych F (2014), Clustering of HCV coinfections on HIV phylogeny indicates domestic and sexual transmission of HCV., in International journal of epidemiology, 43(3), 887-96.
Cohort profile: Antiretroviral Therapy Cohort Collaboration (ART-CC).
May Margaret T, Ingle Suzanne M, Costagliola Dominique, Justice Amy C, de Wolf Frank, Cavassini Matthias, D'Arminio Monforte Antonella, Casabona Jordi, Hogg Robert S, Mocroft Amanda, Lampe Fiona C, Dabis François, Fätkenheuer Gerd, Sterling Timothy R, del Amo Julia, Gill M John, Crane Heidi M, Saag Michael S, Guest Jodie, Brodt Hans-Reinhard, Sterne Jonathan A C (2014), Cohort profile: Antiretroviral Therapy Cohort Collaboration (ART-CC)., in International journal of epidemiology, 43(3), 691-702.
Co-trimoxazole prophylaxis is associated with reduced risk of incident tuberculosis in participants in the Swiss HIV Cohort Study.
Hasse Barbara, Walker A Sarah, Fehr Jan, Furrer Hansjakob, Hoffmann Matthias, Battegay Manuel, Calmy Alexandra, Fellay Jacques, Di Benedetto Caroline, Weber Rainer, Ledergerber Bruno (2014), Co-trimoxazole prophylaxis is associated with reduced risk of incident tuberculosis in participants in the Swiss HIV Cohort Study., in Antimicrobial agents and chemotherapy, 58(4), 2363-8.
Delayed HIV diagnosis and initiation of antiretroviral therapy: inequalities by educational level, COHERE in EuroCoord.
Socio-economic Inequalities and HIV Writing Group for Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord, Lodi Sara, Dray-Spira Rosemary, Touloumi Giota, Braun Dominique, Teira Ramon, D'Arminio Monforte Antonella, Gallois Anne, Zangerle Robert, Spire Bruno, Dabis Francois, Stähelin Cornelia, Termote Monique, Kirk Ole, Chêne Genevieve, Egger Matthias, del Amo Julia (2014), Delayed HIV diagnosis and initiation of antiretroviral therapy: inequalities by educational level, COHERE in EuroCoord., in AIDS (London, England), 28(15), 2297-306.
Development of a definition for Rapid Progression (RP) of renal function in HIV-positive persons: the D:A:D study.
Kamara David A, Ryom Lene, Ross Michael, Kirk Ole, Reiss Peter, Morlat Philippe, Moranne Olivier, Fux Christoph A, Mocroft Amanda, Sabin Caroline, Lundgren Jens D, Smith Colette J (2014), Development of a definition for Rapid Progression (RP) of renal function in HIV-positive persons: the D:A:D study., in BMC nephrology, 15, 51-51.
Disentangling human tolerance and resistance against HIV.
Regoes Roland R, McLaren Paul J, Battegay Manuel, Bernasconi Enos, Calmy Alexandra, Günthard Huldrych F, Hoffmann Matthias, Rauch Andri, Telenti Amalio, Fellay Jacques (2014), Disentangling human tolerance and resistance against HIV., in PLoS biology, 12(9), 1001951-1001951.
Effects of alpha interferon treatment on intrinsic anti-HIV-1 immunity in vivo.
Abdel-Mohsen Mohamed, Deng Xutao, Liegler Teri, Guatelli John C, Salama Mohamed S, Ghanem Hussam El-din A, Rauch Andri, Ledergerber Bruno, Deeks Steven G, Günthard Huldrych F, Wong Joseph K, Pillai Satish K (2014), Effects of alpha interferon treatment on intrinsic anti-HIV-1 immunity in vivo., in Journal of virology, 88(1), 763-7.
Efficacy of lead-in silibinin and subsequent triple therapy in difficult-to-treat HIV/hepatitis C virus-coinfected patients.
Braun D L, Rauch A, Durisch N, Eberhard N, Anagnostopoulos A, Ledergerber B, Metzner K J, Böni J, Weber R, Fehr J (2014), Efficacy of lead-in silibinin and subsequent triple therapy in difficult-to-treat HIV/hepatitis C virus-coinfected patients., in HIV medicine, 15(10), 625-30.
Factors associated with short-term changes in HIV viral load and CD4 R cell count in antiretroviral-naive individuals
Nakagawa Fumiyo (2014), Factors associated with short-term changes in HIV viral load and CD4 R cell count in antiretroviral-naive individuals, in AIDS, 28(9), 1351-1356.
Flexible Marginal Structural Models for Estimating the Cumulative Effect of a Time-Dependent Treatment on the Hazard: Reassessing the Cardiovascular Risks of Didanosine Treatment in the Swiss HIV Cohort Study
Xiao Yongling, Abrahamowicz Michal, Moodie Erica E. M., Weber Rainer, Young James (2014), Flexible Marginal Structural Models for Estimating the Cumulative Effect of a Time-Dependent Treatment on the Hazard: Reassessing the Cardiovascular Risks of Didanosine Treatment in the Swiss HIV Cohort Study, in JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, (506), 455-464.
Higher risk of incident hepatitis C virus coinfection among men who have sex with men, in whom the HIV genetic bottleneck at transmission was wide.
Kouyos Roger D, Rauch Andri, Braun Dominique L, Yang Wan-Lin, Böni Jürg, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Shah Cyril, Kovari Helen, Calmy Alexandra, Cavassini Matthias, Battegay Manuel, Vernazza Pietro L, Bernasconi Enos, Ledergerber Bruno, Günthard Huldrych F, Swiss HIV Cohort Study (SHCS) (2014), Higher risk of incident hepatitis C virus coinfection among men who have sex with men, in whom the HIV genetic bottleneck at transmission was wide., in The Journal of infectious diseases, 210(10), 1555-61.
Highly pathogenic adapted HIV-1 strains limit host immunity and dictate rapid disease progression.
Dalmau Judith, Rotger Margalida, Erkizia Itziar, Rauch Andri, Reche Pedro, Pino Maria, Esteve Anna, Palou Eduard, Brander Christian, Paredes Roger, Phung Pham, Clotet Bonaventura, Telenti Amalio, Martinez-Picado Javier, Prado Julia G (2014), Highly pathogenic adapted HIV-1 strains limit host immunity and dictate rapid disease progression., in AIDS (London, England), 28(9), 1261-72.
HLA Class I and KIR Genes Do Not Protect Against HIV Type 1 Infection in Highly Exposed Uninfected Individuals With Hemophilia A
Vince Nicolas, Bashirova Arman A., Lied Alexandra, Gao Xiaojiang, Dorrell Lucy, McLaren Paul J., Fellay Jacques, Carrington Mary (2014), HLA Class I and KIR Genes Do Not Protect Against HIV Type 1 Infection in Highly Exposed Uninfected Individuals With Hemophilia A, in JOURNAL OF INFECTIOUS DISEASES, 210(7), 1047-1051.
Immunodeficiency at the start of combination antiretroviral therapy in low-, middle-, and high-income countries.
IeDEA and ART Cohort Collaborations, Avila Dorita, Althoff Keri N, Mugglin Catrina, Wools-Kaloustian Kara, Koller Manuel, Dabis François, Nash Denis, Gsponer Thomas, Sungkanuparph Somnuek, McGowan Catherine, May Margaret, Cooper David, Chimbetete Cleophas, Wolff Marcelo, Collier Ann, McManus Hamish, Davies Mary-Ann, Costagliola Dominique, Crabtree-Ramirez Brenda, Chaiwarith Romanee, Cescon Angela, Cornell Morna, Diero Lameck, Phanuphak Praphan (2014), Immunodeficiency at the start of combination antiretroviral therapy in low-, middle-, and high-income countries., in Journal of acquired immune deficiency syndromes (1999), 65(1), 8-16.
Impact of risk factors for specific causes of death in the first and subsequent years of antiretroviral therapy among HIV-infected patients.
Ingle Suzanne M, May Margaret T, Gill M John, Mugavero Michael J, Lewden Charlotte, Abgrall Sophie, Fätkenheuer Gerd, Reiss Peter, Saag Michael S, Manzardo Christian, Grabar Sophie, Bruyand Mathias, Moore David, Mocroft Amanda, Sterling Timothy R, D'Arminio Monforte Antonella, Hernando Victoria, Teira Ramon, Guest Jodie, Cavassini Matthias, Crane Heidi M, Sterne Jonathan A C, Antiretroviral Therapy Cohort Collaboration (2014), Impact of risk factors for specific causes of death in the first and subsequent years of antiretroviral therapy among HIV-infected patients., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 59(2), 287-97.
Increased risk of cardiovascular disease (CVD) with age in HIV-positive men: a comparison of the D:A:D CVD risk equation and general population CVD risk equations.
Petoumenos K, Reiss P, Ryom L, Rickenbach M, Sabin C A, El-Sadr W, d'Arminio Monforte A, Phillips A N, De Wit S, Kirk O, Dabis F, Pradier C, Lundgren J D, Law M G, D:A:D study group (2014), Increased risk of cardiovascular disease (CVD) with age in HIV-positive men: a comparison of the D:A:D CVD risk equation and general population CVD risk equations., in HIV medicine, 15(10), 595-603.
LILRB2 interaction with HLA class I correlates with control of HIV-1 infection.
Bashirova Arman A, Martin-Gayo Enrique, Jones Des C, Qi Ying, Apps Richard, Gao Xiaojiang, Burke Patrick S, Taylor Craig J, Rogich Jerome, Wolinsky Steven, Bream Jay H, Duggal Priya, Hussain Shehnaz, Martinson Jeremy, Weintrob Amy, Kirk Gregory D, Fellay Jacques, Buchbinder Susan P, Goedert James J, Deeks Steven G, Pereyra Florencia, Trowsdale John, Lichterfeld Mathias, Telenti Amalio, Walker Bruce D (2014), LILRB2 interaction with HLA class I correlates with control of HIV-1 infection., in PLoS genetics, 10(3), 1004196-1004196.
Limited clinical benefit of minority K103N and Y181C-variant detection in addition to routine genotypic resistance testing in antiretroviral therapy-naive patients.
Metzner Karin J, Scherrer Alexandra U, von Wyl Viktor, Böni Jürg, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Furrer Hansjakob, Hirsch Hans H, Vernazza Pietro L, Cavassini Matthias, Calmy Alexandra, Bernasconi Enos, Weber Rainer, Günthard Huldrych F (2014), Limited clinical benefit of minority K103N and Y181C-variant detection in addition to routine genotypic resistance testing in antiretroviral therapy-naive patients., in AIDS (London, England), 28(15), 2231-9.
Long-term mortality in HIV-positive individuals virally suppressed for >3 years with incomplete CD4 recovery.
Engsig Frederik N, Zangerle Robert, Katsarou Olga, Dabis Francois, Reiss Peter, Gill John, Porter Kholoud, Sabin Caroline, Riordan Andrew, Fätkenheuer Gerd, Gutiérrez Félix, Raffi Francois, Kirk Ole, Mary-Krause Murielle, Stephan Christoph, de Olalla Patricia Garcia, Guest Jodie, Samji Hasina, Castagna Antonella, d'Arminio Monforte Antonella, Skaletz-Rorowski Adriane, Ramos Jose, Lapadula Giuseppe, Mussini Cristina, Force Lluís (2014), Long-term mortality in HIV-positive individuals virally suppressed for >3 years with incomplete CD4 recovery., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 58(9), 1312-21.
Major challenges in clinical management of TB/HIV co-infected patients in Eastern Europe compared with Western Europe and Latin America.
Efsen Anne Marie, Schultze Anna, Post Frank, Panteleev Alexander, Furrer Hansjakob, Miller Robert, Skrahin Aliaksandr, Losso Marcelo H, Toibaro Javier, Girardi Enrico, Miro José, Bruyand Mathias, Obel Niels, Caylá Joan, Podlekareva Daria, Lundgren Jens, Mocroft Amanda, Kirk Ole (2014), Major challenges in clinical management of TB/HIV co-infected patients in Eastern Europe compared with Western Europe and Latin America., in Journal of the International AIDS Society, 17(4 Suppl 3), 19505-19505.
Mortality in patients with HIV-1 infection starting antiretroviral therapy in South Africa, Europe, or North America: a collaborative analysis of prospective studies.
Boulle Andrew, Schomaker Michael, May Margaret T, Hogg Robert S, Shepherd Bryan E, Monge Susana, Keiser Olivia, Lampe Fiona C, Giddy Janet, Ndirangu James, Garone Daniela, Fox Matthew, Ingle Suzanne M, Reiss Peter, Dabis Francois, Costagliola Dominique, Castagna Antonella, Ehren Kathrin, Campbell Colin, Gill M John, Saag Michael, Justice Amy C, Guest Jodie, Crane Heidi M, Egger Matthias (2014), Mortality in patients with HIV-1 infection starting antiretroviral therapy in South Africa, Europe, or North America: a collaborative analysis of prospective studies., in PLoS medicine, 11(9), 1001718-1001718.
Obesity Trends and Body Mass Index Changes After Starting Antiretroviral Treatment: The Swiss HIV Cohort Study.
Hasse Barbara, Iff Martin, Ledergerber Bruno, Calmy Alexandra, Schmid Patrick, Hauser Christoph, Cavassini Matthias, Bernasconi Enos, Marzolini Catia, Tarr Philip E, Tarr Philip E, Aubert V, Barth J, Battegay M, Bernasconi E, Böni J, Bucher H C, Burton-Jeangros C, Calmy A, Cavassini M, Egger M, Elzi L, Fehr J, Fellay J, Furrer H (2014), Obesity Trends and Body Mass Index Changes After Starting Antiretroviral Treatment: The Swiss HIV Cohort Study., in Open forum infectious diseases, 1(2), 040-040.
Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries
Lodi Sara (2014), Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries, in AIDS, 28(16), 2461-2473.
Partial rescue of V1V2 mutant infectivity by HIV-1 cell-cell transmission supports the domain's exceptional capacity for sequence variation
Brandenberg Oliver F., Rusert Peter, Magnus Carsten, Weber Jacqueline, Boeni Juerg, Guenthard Huldrych F., Regoes Roland R., Trkola Alexandra (2014), Partial rescue of V1V2 mutant infectivity by HIV-1 cell-cell transmission supports the domain's exceptional capacity for sequence variation, in RETROVIROLOGY, 11(1), 75-22.
Population pharmacokinetic modelling and evaluation of different dosage regimens for darunavir and ritonavir in HIV-infected individuals
Arab-Alameddine M., Lubomirov R., Fayet-Mello A., Aouri M., Rotger M., Buclin T., Widmer N., Gatri M., Ledergerber B., Rentsch K., Cavassini M., Panchaud A., Guidi M., Telenti A., Decosterd L. A., Csajka C. (2014), Population pharmacokinetic modelling and evaluation of different dosage regimens for darunavir and ritonavir in HIV-infected individuals, in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 69(9), 2489-2498.
Predictors of advanced chronic kidney disease and end-stage renal disease in HIV-positive persons.
Ryom Lene, Mocroft Amanda, Kirk Ole, Ross Michael, Reiss Peter, Fux Christophe A, Morlat Philippe, Moranne Olivier, Smith Colette, El-Sadr Wafaa, Law Matthew, Lundgren Jens D (2014), Predictors of advanced chronic kidney disease and end-stage renal disease in HIV-positive persons., in AIDS (London, England), 28(2), 187-99.
Prevalence and risk factors of late presentation for HIV diagnosis and care in a tertiary referral centre in Switzerland.
Buetikofer S, Wandeler G, Kouyos R, Weber R, Ledergerber B (2014), Prevalence and risk factors of late presentation for HIV diagnosis and care in a tertiary referral centre in Switzerland., in Swiss medical weekly, 144, 13961-13961.
Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons.
Shepherd Leah, Souberbielle Jean-Claude, Bastard Jean-Philippe, Fellahi Soraya, Capeau Jaqueline, Reekie Joanne, Reiss Peter, Blaxhult Anders, Bickel Markus, Leen Clifford, Kirk Ole, Lundgren Jens D, Mocroft Amanda, Viard Jean-Paul (2014), Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons., in The Journal of infectious diseases, 210(2), 234-43.
Qualitative analysis of barriers and facilitators encountered by HIV patients in an ART adherence programme.
Krummenacher Isabelle, Spencer Brenda, Du Pasquier Sophie, Bugnon Olivier, Cavassini Matthias, Schneider Marie P (2014), Qualitative analysis of barriers and facilitators encountered by HIV patients in an ART adherence programme., in International journal of clinical pharmacy, 36(4), 716-24.
Role of microRNA modulation in the interferon-α/ribavirin suppression of HIV-1 in vivo.
Abdel-Mohsen Mohamed, Deng Xutao, Danesh Ali, Liegler Teri, Jacobs Evan S, Rauch Andri, Ledergerber Bruno, Norris Philip J, Günthard Huldrych F, Wong Joseph K, Pillai Satish K (2014), Role of microRNA modulation in the interferon-α/ribavirin suppression of HIV-1 in vivo., in PloS one, 9(10), 109220-109220.
Safety and immunogenicity of the M72/AS01 candidate tuberculosis vaccine in HIV-infected adults on combination antiretroviral therapy: a phase I/II, randomized trial.
Thacher Eleonora G, Cavassini Matthias, Audran Régine, Thierry Anne-Christine, Bollaerts Anne, Cohen Joe, Demoitié Marie-Ange, Ejigu Dawit, Mettens Pascal, Moris Philippe, Ofori-Anyinam Opokua, Spertini François (2014), Safety and immunogenicity of the M72/AS01 candidate tuberculosis vaccine in HIV-infected adults on combination antiretroviral therapy: a phase I/II, randomized trial., in AIDS (London, England), 28(12), 1769-81.
Sexually transmitted infections in HIV-infected people in Switzerland: cross-sectional study.
Sprenger Katharina, Evison John Marc, Zwahlen Marcel, Vogt Cedric M, Elzi Maria Verena, Hauser Christoph, Furrer Hansjakob, Low Nicola (2014), Sexually transmitted infections in HIV-infected people in Switzerland: cross-sectional study., in PeerJ, 2, 537-537.
Short- and long-term mortality and causes of death in HIV/tuberculosis patients in Europe.
Podlekareva Daria N, Panteleev Alexander M, Grint Daniel, Post Frank A, Miro Jose M, Bruyand Mathias, Furrer Hansjakob, Obel Niels, Girardi Enrico, Vasilenko Anna, Losso Marcelo H, Arenas-Pinto Alejandro, Caylá Joan, Rakhmanova Aza, Zeltina Indra, Werlinrud Anne Marie, Lundgren Jens D, Mocroft Amanda, Kirk Ole, HIV/TB study group (2014), Short- and long-term mortality and causes of death in HIV/tuberculosis patients in Europe., in The European respiratory journal, 43(1), 166-77.
Social meets molecular: Combining phylogenetic and latent class analyses to understand HIV-1 transmission in Switzerland.
Avila Dorita, Keiser Olivia, Egger Matthias, Kouyos Roger, Böni Jürg, Yerly Sabine, Klimkait Thomas, Vernazza Pietro L, Aubert Vincent, Rauch Andri, Bonhoeffer Sebastian, Günthard Huldrych F, Stadler Tanja, Spycher Ben D (2014), Social meets molecular: Combining phylogenetic and latent class analyses to understand HIV-1 transmission in Switzerland., in American journal of epidemiology, 179(12), 1514-25.
Temporal trends in prognostic markers of HIV-1 virulence and transmissibility: an observational cohort study.
Pantazis Nikos, Porter Kholoud, Costagliola Dominique, De Luca Andrea, Ghosn Jade, Guiguet Marguerite, Johnson Anne M, Kelleher Anthony D, Morrison Charles, Thiebaut Rodolphe, Wittkop Linda, Touloumi Giota (2014), Temporal trends in prognostic markers of HIV-1 virulence and transmissibility: an observational cohort study., in The lancet. HIV, 1(3), 119-26.
The IFNL3/4 ΔG variant increases susceptibility to cytomegalovirus retinitis among HIV-infected patients.
Bibert Stéphanie, Wojtowicz Agnieszka, Taffé Patrick, Manuel Oriol, Bernasconi Enos, Furrer Hansjakob, Günthard Huldrych F, Hoffmann Matthias, Kaiser Laurent, Osthoff Michael, Cavassini Matthias, Bochud Pierre-Yves, Swiss HIV Cohort Study (2014), The IFNL3/4 ΔG variant increases susceptibility to cytomegalovirus retinitis among HIV-infected patients., in AIDS (London, England), 28(13), 1885-9.
The rate of recovery in renal function when patients with HIV infection discontinue treatment with tenofovir.
Young J, Wang Q, Fux C A, Bernasconi E, Furrer H, Vernazza P, Calmy A, Cavassini M, Weber R, Battegay M, Bucher H C, Swiss HIV Cohort Study (2014), The rate of recovery in renal function when patients with HIV infection discontinue treatment with tenofovir., in HIV medicine, 15(8), 505-10.
Treatment-naive individuals are the major source of transmitted HIV-1 drug resistance in men who have sex with men in the Swiss HIV Cohort Study.
Drescher Sara M, von Wyl Viktor, Yang Wan-Lin, Böni Jürg, Yerly Sabine, Shah Cyril, Aubert Vincent, Klimkait Thomas, Taffé Patrick, Furrer Hansjakob, Battegay Manuel, Ambrosioni Juan, Cavassini Matthias, Bernasconi Enos, Vernazza Pietro L, Ledergerber Bruno, Günthard Huldrych F, Kouyos Roger D, Swiss HIV Cohort Study (2014), Treatment-naive individuals are the major source of transmitted HIV-1 drug resistance in men who have sex with men in the Swiss HIV Cohort Study., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 58(2), 285-94.
Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration.
Smith Colette J, Ryom Lene, Weber Rainer, Morlat Philippe, Pradier Christian, Reiss Peter, Kowalska Justyna D, de Wit Stephane, Law Matthew, el Sadr Wafaa, Kirk Ole, Friis-Moller Nina, Monforte Antonella d'Arminio, Phillips Andrew N, Sabin Caroline A, Lundgren Jens D, D:A:D Study Group (2014), Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration., in Lancet (London, England), 384(9939), 241-8.
Using an epidemiological model for phylogenetic inference reveals density dependence in HIV transmission.
Leventhal Gabriel E, Günthard Huldrych F, Bonhoeffer Sebastian, Stadler Tanja (2014), Using an epidemiological model for phylogenetic inference reveals density dependence in HIV transmission., in Molecular biology and evolution, 31(1), 6-17.
Virologic and immunologic responses in treatment-naive patients to ritonavir-boosted atazanavir or efavirenz with a common backbone.
Swiss HIV Cohort Study, Wang Qing, Young Jim, Bernasconi Enos, Vernazza Pietro, Calmy Alexandra, Cavassini Matthias, Furrer Hansjakob, Fehr Jan, Bucher Heiner C, Battegay Manuel (2014), Virologic and immunologic responses in treatment-naive patients to ritonavir-boosted atazanavir or efavirenz with a common backbone., in HIV clinical trials, 15(3), 92-103.

Collaboration

Group / person Country
Types of collaboration
NICER Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
General Hospital Corporation, Masschusetts General Hospital, United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
P. Klenermann, Nuffield Dept of Int. Medicine, Univ. of Oxford Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
J. Fellay Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
MITOC Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
ART-CC Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Plato II Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
CH. Frazer, Imperial College, London Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
NESCent United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
S. Alizon, Univ Montpellier, France France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Swiss Tropical and Public Health Institute, Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
PENTA/ECS Italy (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
CHAIN Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
L. Décosterd, CHUV Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Cascade Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Marina Klein, McGill University, Montreal Canada (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
J. Fellay Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
O. Aalen, Norway, and J. Sterne, Bristol University, UK Norway (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Cohere Denmark (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
DAD Denmark (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
A. Oxenius, ETHZ Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
TB: HIV Denmark (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
L. Held, Biostatistik, UZH Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
N. Beerenwinkel, ETHZ Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
S. Franceschi, IARC, Lyon, France France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
S. Bonhoeffer/T. Stadler, ETHZ Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Penta-EICG Italy (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
HIV CAUSAL United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
EuroSIDA Denmark (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
NAACCORD United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
P. Lemey, University of Leuven, Belgium Belgium (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
ACHIeV2E Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
C. Nordt, Psych. Universitätsklinik (PUK) Zürich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
J. McCarthy, Duke University, Durham, USA United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Communication with the public

Communication Title Media Place Year
Other activities Newsletter für Patienten und Interessierte Rhaeto-Romanic Switzerland International Western Switzerland Italian-speaking Switzerland German-speaking Switzerland 2016

Associated projects

Number Title Start Funding scheme
120793 Minority quasispecies of drug-resistant HIV-1: Emergence, transmission, dynamics, and clinical relevance in acute and chronic HIV-1 infection 01.11.2008 Project funding (special)
135745 ER Niacin/laropiprant impact on cardiovascular markers and atheroprogression in HIV-infected individuals on cART: the NILACH trial 01.01.2012 Project funding (special)
163348 Longitudinal Neurocognitive Assessment in the Metabolic and Aging Cohort of the Swiss HIV Cohort Study: the NAMACO study 01.01.2016 Project funding (special)
177499 Swiss HIV Cohort Study (SHCS) 01.01.2018 Cohort Studies Large
103560 Cost-effectiveness of genotypic and phenotypic antiretroviral resistance testing in HIV infected patients 01.07.2004 Project funding (special)
112655 Managing variability in HIV therapy: integration of pharmacogenetics, pharmacokinetics and pharmacodynamics of antiretroviral drugs 01.04.2006 Project funding (special)
131629 Long-term antiretroviral therapy of HIV-infected patients in sub-Saharan Africa - insights from causal and mathematical modelling 01.01.2011 Ambizione
114006 Monotherapy in Switzerland and Thailand (MOST-cohort) 01.10.2006 Project funding (special)
159868 HIV-1 Transmission in Switzerland: viral transmission traits, superinfection and drug resistance 01.05.2015 Project funding (special)
146331 HIV-1 whole-genome quasispecies analysis in longitudinal clinical samples 01.04.2013 Interdisciplinary projects
108787 Swiss HIV Cohort Study 01.04.2006 Cohort Studies Large
146143 Understanding and Predicting the Hepatitis C Epidemic in HIV-infected Patients 01.05.2013 Project funding (special)
110012 Host genetic and genomic determinants of susceptibility to HIV-1 01.11.2005 Project funding (Div. I-III)
125441 Molecular and clinical epidemiology of tuberculosis in Switzerland: Studies of populations infected and not infected with HIV 01.04.2009 Project funding (special)
141067 HIV-1 integration sites and their impact on HIV-1 pathogenesis 01.04.2012 Project funding (Div. I-III)
142411 Combining molecular epidemiology approaches and mathematical models for the spread of HIV and its coinfections 01.10.2012 Ambizione
136820 Estimating epidemiological and evolutionary parameters from viral sequence data using phylogenetic methods 01.01.2012 Ambizione
173061 Screening of gestational diabetes mellitus in early pregnancy by oral glucose tolerance test and glycosylated fibronectin: an international, prospective, multi-centre cross-sectional study 01.04.2017 Project funding (Div. I-III)
116035 Factors associated with viral control after primary HIV-1 infection and viral determinants associated with HIV-1 transmission 01.04.2007 Project funding (special)
124943 Pharmacocinétique de population, pharmacogénétique, et profils métaboliques de la thérapie anti-HIV 01.04.2009 Project funding (special)
144209 Dynamics of atherosclerosis progression in HIV-infected and HIV-uninfected persons - a longitudinal study using coronary computed tomography angiography 01.07.2013 Project funding (special)
127017 HIV-1 whole-genome quasispecies analysis by ultra-deep sequencing and computational haplotype inference to determine the mechanisms of drug resistance development 01.01.2010 Interdisciplinary projects
116862 Impact of HIV and antiretroviral therapy on Hepatitis C virus (HCV) evolution and on HCV-specific cellular immunity 01.06.2007 Project funding (special)
112594 HIV-1 drug resistance in the swiss HIV cohort study: epidemiology and impact on the management of HIV infected patients 01.05.2006 Project funding (special)
136737 Acute and chronic dynamics of HIV and HCV infections, within-host evolution and epidemiological outcomes 01.10.2011 Ambizione
103748 Humoral immunity to HIV-1: Analysis of the function of antibody responses as correlate and surrogate marker of viremia control 01.04.2004 Project funding (Div. I-III)
134277 Swiss HIV Cohort Study (SHCS) 01.01.2011 Cohort Studies Large
132863 Host evolutionary genomics of HIV-1 and other retroviruses 01.11.2010 Project funding (Div. I-III)
130865 HIV-1 Transmission in Switzerland: Long term-molecular epidemiology and biological properties of transmitted viruses 01.11.2010 Project funding (special)
141234 Pharmacologie clinique et pharmacogénétique de la prise en charge complexe des sujets infectés par HIV ou co-infectés par HIV et HCV 01.04.2012 Project funding (special)
65168 Analysis of the correlates of protection in structured intermittent therapy: An in vivo model of acute HIV infection? 01.10.2001 Project funding (special)
127631 Contribution of multiple genetic variants, identified in genome-wide association studies, to coronary artery disease in HIV-infected individuals 01.12.2009 Project funding (special)
142403 Relevance of different CD4+ T-cell subsets for antifungal defense. What is aberrant in immunocompromised patients? 01.01.2013 Ambizione

Abstract

The Swiss HIV Cohort Study (SHCS), established in 1988, is an ongoing, longitudinal, clinic-based cohort of HIV-1 infected adults. Until to date, cumulatively, 17'795 persons have been enrolled. The strength of the cohort is the comprehensive collection of clinical, laboratory and socio-demographic data as well as biological samples from enrolled individuals every 3 - 6 months accompanied by a strict quality control program. The size and duration of the cohort allowed for the formation of a world-wide exceptional biobank which currently contains > 1.3 mio specimens from HIV infected individuals and thereby provides a unique research platform for clinical, translational, epidemiological, social and basic research worldwide. Due to its continuing success in recruiting patients, the SHCS is representative of the Swiss HIV-1 infected population. Likewise, due to its longevity, comprehensive and high quality data collection, the SHCS will continue to provide invaluable data for public health as best evidenced by the major impact on the high quality of HIV care the SHCS has had in Switzerland. An important reason for this success remains that all key players in Swiss HIV medicine are participating in the SHCS which guarantees that research results are rapidly transformed into clinical care. With its drug resistance database containing > 19000 pol genotypes and its host genetic database of > 2500 whole human genomes, the SHCS is in a position to actively contribute to large international collaborations to resolve research questions that cannot be resolved by single cohorts. Key to success of the SHCS are also two further important factors, the clear dedication to a multidisciplinary approach which promotes crossing of conventional research areas and the system of nested research projects that allows to rapidly respond to the needs of the continuously changing HIV epidemic.
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