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Profaning the ultimate sanctuary: HIV latency in hematopoietic stem cells.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2011
Author Trono Didier, Marzetta Flavia,
Project KRAB/KAP1 epigenetic regulation in the control of memory and emotional traits: from mice to humans.
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Original article (peer-reviewed)

Journal Cell host & microbe
Volume (Issue) 9(3)
Page(s) 170 - 2
Title of proceedings Cell host & microbe
DOI 10.1016/j.chom.2011.03.001

Abstract

The early establishment of a reservoir of latently infected T cells is a sobering obstacle to HIV eradication, in spite of the efficacy of current antiretroviral therapies. That latent proviruses might also hide in multipotent hematopoietic stem cells suggests an even more formidable challenge and potentially has therapeutic implications.
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