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Endothelial-to-hematopoietic transition: Notch-ing vessels into bloodEndothelial-to-hematopoietic transition

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Kanz Dirk, Konantz Martina, Alghisi Elisa, North Trista E., Lengerke Claudia,
Project Role and molecular targets of the transcription factor EVI1 in lymphoblastic leukemia and blood stem cell development
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Review article (peer-reviewed)

Journal Annals of the New York Academy of Sciences
Volume (Issue) 1370(1)
Page(s) 97 - 108
Title of proceedings Annals of the New York Academy of Sciences
DOI 10.1111/nyas.13030

Abstract

During development, hematopoietic stem cells (HSCs) are formed in a temporally and spatially restricted manner, arising from specialized endothelial cells (ECs) in the ventral wall of the dorsal aorta within the evolutionary conserved aorta-gonad-mesonephros region. Our understanding of the processes regulating the birth of HSCs from ECs has been recently advanced by comprehensive molecular analyses of developing murine hematopoietic cell populations complemented by studies in the zebrafish model, with the latter offering unique advantages for genetic studies and direct in vivo visualization of HSC emergence. Here, we provide a concise review of the current knowledge and recent advances regarding the cellular origin and molecular regulation of HSC development, with particular focus on the process of endothelial-to-hematopoietic transition and its primary regulator, the Notch signaling pathway.
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