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Adrenomedullin: a vasodilator to treat sepsis?

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Publication date 2014
Author Pugin J,
Project Alarmins as mediators of aseptic inflammatory responses and sepsis
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Review article (peer-reviewed)

Journal Crit Care
Volume (Issue) 18(3)
Page(s) 152
Title of proceedings Crit Care
DOI 10.1186/cc13924


Adrenomedullin is a vasodilatory polypeptide with pleiotropic effects secreted by various organs. Adrenomedullin is produced first as a prepropeptide, and then cleaved into mature adrenomedullin and mid-regional proadrenomedullin. Whereas levels of the latter have been shown to correlate with severity of sepsis and carry prognostic value, adrenomedullin plays a role in vascular tone homeostasis. In the previous issue of Critical Care, the infusion of exogenous adrenomedullin is suggested to protect against increased lung endothelial permeability and end-organ dysfunction in a model of pneumococcal pneumonia in mechanically ventilated mice, possibly by stabilizing vascular endothelia. Since adrenomedullin is a strong vasodilatory molecule, further studies are needed to evaluate its potential as a future treatment of sepsis.