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Amplification of Chirality by Supramolecular Polymerization of Pyrene Oligomers

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2011
Author Nussbaumer Alina L., Studer Daniel, Malinovskii Vladimir L., Häner Robert,
Project DNA-assisted self-organization of aromatic chromophores
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Original article (peer-reviewed)

Journal Angew. Chem. Int. Ed.
Volume (Issue) 24
Page(s) 5490 - 5494
Title of proceedings Angew. Chem. Int. Ed.
DOI 10.1002/anie.201100677

Abstract

Chiral amplification was observed with short pyrene oligomers containing a flexible phosphodiester backbone in aqueous conditions. Highest anisotropy factors were found in the presence of lesser quantities of the chiral inductor, a pyrene oligomer containing a single 2’-deoxycytidine. Data obtained from UV/Vis, fluorescence and CD spectroscopy, as well as gel mobility experiments and electron microscopy support a model in which pyrene oligomers form helical, supramolecular polymers through interstrand stacking interactions. The oligomers described herein represent a new type of oligomeric building blocks that form supramolecular polymers.
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