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Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Scherrer Alexandra U, Yang Wan-Lin, Kouyos Roger D, Böni Jürg, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Cavassini Matthias, Battegay Manuel, Hauser Christoph, Calmy Alexandra, Schmid Patrick, Bernasconi Enos, Günthard Huldrych F,
Project Swiss HIV Cohort Study (SHCS)
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Original article (peer-reviewed)

Journal The Journal of infectious diseases
Volume (Issue) 214(3)
Page(s) 399 - 402
Title of proceedings The Journal of infectious diseases
DOI 10.1093/infdis/jiw165


The prevalence of integrase strand transfer inhibitor (INSTI)-transmitted drug resistance (TDR) may increase with the increasing use of INSTIs. We analyzed the prevalence of INSTI TDR in the Swiss HIV Cohort Study (2008-2014). In 1 of 1316 drug-naive samples (0.1%), a major INSTI TDR mutation was detected. Prevalence was stable, although INSTIs were increasingly used. We showed that this is in contrast to the introduction of previous drug classes, in which more treatment failures with resistant strains occurred and TDR was observed more rapidly. We demonstrated on a population-level that it is possible to avoid TDR to a new drug class for years.