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Hedgehog Signaling in Malignant Pleural Mesothelioma.

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Felley-Bosco Emanuela, Opitz Isabelle, Meerang Mayura,
Project From asbestos-exposure to cancer: a systemic approach to detect loss of homeostatic control in the mesothelial environment
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Review article (peer-reviewed)

Journal Genes
Volume (Issue) 6(3)
Page(s) 500 - 11
Title of proceedings Genes
DOI 10.3390/genes6030500

Open Access

Abstract

Malignant pleural mesothelioma (MPM) is a cancer associated with exposure to asbestos fibers, which accumulate in the pleural space, damage tissue and stimulate regeneration. Hedgehog signaling is a pathway important during embryonic mesothelium development and is inactivated in adult mesothelium. The pathway is reactivated in some MPM patients with poor clinical outcome, mainly mediated by the expression of the ligands. Nevertheless, mutations in components of the pathway have been observed in a few cases. Data from different MPM animal models and primary culture suggest that both autocrine and paracrine Hedgehog signaling are important to maintain tumor growth. Drugs inhibiting the pathway at the level of the smoothened receptor (Smo) or glioma-associated protein transcription factors (Gli) have been used mostly in experimental models. For clinical development, biomarkers are necessary for the selection of patients who can benefit from Hedgehog signaling inhibition.
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