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Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author An Ping, Penugonda Sudhir, Thorball Christian W, Bartha Istvan, Goedert James J, Donfield Sharyne, Buchbinder Susan, Binns-Roemer Elizabeth, Kirk Gregory D, Zhang Wenyan, Fellay Jacques, Yu Xiao-Fang, Winkler Cheryl A,
Project Swiss HIV Cohort Study (SHCS)
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Original article (peer-reviewed)

Journal PLoS genetics
Volume (Issue) 12(3)
Page(s) 1005921 - 1005921
Title of proceedings PLoS genetics
DOI 10.1371/journal.pgen.1005921

Open Access

URL http://doi.org/10.1371/journal.pgen.1005921
Type of Open Access Publisher (Gold Open Access)

Abstract

Human APOBEC3 cytidine deaminases are intrinsic resistance factors to HIV-1. However, HIV-1 encodes a viral infectivity factor (Vif) that degrades APOBEC3 proteins. In vitro APOBEC3F (A3F) anti-HIV-1 activity is weaker than A3G but is partially resistant to Vif degradation unlike A3G. It is unknown whether A3F protein affects HIV-1 disease in vivo. To assess the effect of A3F gene on host susceptibility to HIV- acquisition and disease progression, we performed a genetic association study in six well-characterized HIV-1 natural cohorts. A common six-Single Nucleotide Polymorphism (SNP) haplotype of A3F tagged by a codon-changing variant (p. I231V, with allele (V) frequency of 48% in European Americans) was associated with significantly lower set-point viral load and slower rate of progression to AIDS (Relative Hazards (RH) = 0.71, 95% CI: 0.56, 0.91) and delayed development of pneumocystis pneumonia (PCP) (RH = 0.53, 95% CI: 0.37-0.76). A validation study in the International Collaboration for the Genomics of HIV (ICGH) showed a consistent association with lower set-point viral load. An in vitro assay revealed that the A3F I231V variant may influence Vif mediated A3F degradation. Our results provide genetic epidemiological evidence that A3F modulates HIV-1/AIDS disease progression.
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