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Labeled acetate as a marker of astrocytic metabolism

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Wyss M. T., Magistretti P. J., Buck A., Weber B.,
Project A multimodal approach to cerebral blood flow and metabolism
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Original article (peer-reviewed)

Journal J Cereb Blood Flow Metab
Page(s) 1668 - 74
Title of proceedings J Cereb Blood Flow Metab

Abstract

Astrocytes have various important roles in brain physiology. To further elucidate the details of astrocytic functions under normal and pathological states, astrocyte-specific measurements are mandatory. For studying brain energy metabolism, the use of the astrocyte-specific energy substrate acetate has proven to be of great value. Since the first applications of labeled acetate for brain studies about 50 years ago, numerous methodologies have been developed and employed in compartment-specific investigations of brain metabolism. Here, we provide an overview of these different methodological approaches and review studies employing acetate labeled with the most commonly used carbon isotopes.
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