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The primate model for understanding and restoring vision

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Picaud Serge, Dalkara Deniz, Marazova Katia, Goureau Olivier, Roska Botond, Sahel José-Alain,
Project Visual processing in foveated retinæ in the presence of self-motion
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Original article (peer-reviewed)

Journal Proceedings of the National Academy of Sciences
Volume (Issue) 116(52)
Page(s) 26280 - 26287
Title of proceedings Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1902292116


Retinal degenerative diseases caused by photoreceptor cell death are major causes of irreversible vision loss. As only primates have a macula, the nonhuman primate (NHP) models have a crucial role not only in revealing biological mechanisms underlying high-acuity vision but also in the development of therapies. Successful translation of basic research findings into clinical trials and, moreover, approval of the first therapies for blinding inherited and age-related retinal dystrophies has been reported in recent years. This article explores the value of the NHP models in understanding human vision and reviews their contribution to the development of innovative therapeutic strategies to save and restore vision.