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RALF4/19 peptides interact with LRX proteins to control pollen tube growth in Arabidopsis

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Mecchia Martin A., Santos-Fernandez Gorka, Duss Nadine N., Somoza Sofía C., Boisson-Dernier Aurélien, Gagliardini Valeria, Martínez-Bernardini Andrea, Fabrice Tohnyui Ndinyanka, Ringli Christoph, Muschietti Jorge P., Grossniklaus Ueli,
Project The Genetic and Molecular Basis of Gametogenesis and Maternal Effects in Arabidopsis
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Original article (peer-reviewed)

Journal Science
Volume (Issue) 358(6370)
Page(s) 1600 - 1603
Title of proceedings Science
DOI 10.1126/science.aao5467


The communication of changes in the extracellular matrix to the interior of the cell is crucial for a cell’s function. The extracellular peptides of the RAPID ALKALINIZATION FACTOR (RALF) family have been identified as ligands of receptor-like kinases of the CrRLK1L subclass, but the exact mechanism of their perception is unclear. We found that Arabidopsis RALF4 and RALF19 redundantly regulate pollen tube integrity and growth, and that their function depends on pollen-expressed proteins of the LEUCINE-RICH REPEAT EXTENSIN (LRX) family, which play a role in cell wall development but whose mode of action is not understood. The LRX proteins interact with RALFs, monitoring cell wall changes, which are communicated to the interior of the pollen tube via the CrRLK1L pathway to sustain normal growth.