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Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2016
Author Tietz Silvia M, Zwahlen Marcel, Haghayegh Jahromi Neda, Baden Pascale, Lazarevic Ivana, Enzmann Gaby, Engelhardt Britta,
Project Cell Migration
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Original article (peer-reviewed)

Journal European journal of immunology
Volume (Issue) 46(10)
Page(s) 2481 - 2483
Title of proceedings European journal of immunology
DOI 10.1002/eji.201546272


Considering the 3R rules of animal experimentation, we asked if refined scoring of experimental autoimmune encephalomyelitis (EAE) in mice improves documentation of clinical EAE allowing to perform a more powerful statistical analysis. Surprisingly, refined EAE scoring failed to improve statistical outcome comparing the overall disease courses between two groups of mice.