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Immune system and microbiome in the esophagus: implications for understanding inflammatory diseases

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Kaymak Tanay, Hruz Petr, Niess Jan Hendrik,
Project The Role of IL-20 Cytokine Family Members in Eosinophilic Esophagitis
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Review article (peer-reviewed)

Journal The FEBS Journal
Page(s) febs.16103 - febs.16103
Title of proceedings The FEBS Journal
DOI 10.1111/febs.16103

Open Access

Type of Open Access Publisher (Gold Open Access)


The gastrointestinal tract is the largest compartment of the body's immune system exposed to microorganisms, structural components and metabolites, antigens derived from the diet, and pathogens. Most studies have focused on immune responses in the stomach, the small intestine, and the colon, but the esophagus has remained an understudied anatomic immune segment. Here, we discuss the esophagus' anatomical and physiological distinctions that may account for inflammatory esophageal diseases.