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The role of bacterial phytotoxins in inhibiting the eukaryotic proteasome

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Publication date 2013
Author Dudler Robert,
Project Structure, function and biosynthesis of syrbactins
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Review article (peer-reviewed)

Journal Trends in Microbiology
Volume (Issue) 22(1)
Page(s) 28 - 35
Title of proceedings Trends in Microbiology
DOI 10.1016/j.tim.2013.10.010


The ubiquitin-26S proteasome degradation system (UPS) plays a pivotal role in almost all aspects of plant life, including defending against pathogens. Although the proteasome is important for plant immunity, it has been found to be also exploited by pathogens using effectors to increase their virulence. Recent work on the XopJ effector and syringolin A/syrbactins has highlighted host proteasome inhibition as a virulence strategy of pathogens. This review will focus on these recent developments.