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The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Cai Xingguang, Javor Sacha, Gan Bee Ha, Köhler Thilo, Reymond Jean-Louis,
Project Chemical Space Design of Small Molecules and Peptides
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Original article (peer-reviewed)

Journal Chemical Communications
Volume (Issue) 57(46)
Page(s) 5654 - 5657
Title of proceedings Chemical Communications
DOI 10.1039/d1cc01838h

Open Access

URL http://doi.org/10.1039/D1CC01838H
Type of Open Access Publisher (Gold Open Access)

Abstract

pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar effect occurs with polymyxin B and might be general for polycationic antimicrobials.
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