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NMR Spectroscopy in Bioinorganic Chemistry

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Donghi D, Johannsen S, Sigel RKO, Freisinger E,
Project Coordination Chemistry within the Core of Large RNAs: Regulating Tertiary Contacts and Function
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Review article (peer-reviewed)

Journal CHIMIA
Volume (Issue) 66(10 - issue "NMR In Switzerland")
Page(s) 791 - 797
Title of proceedings CHIMIA
DOI doi:10.2533/chimia.2012.179


Multinuclear and multidimensional nuclear magnetic resonance (NMR) spectroscopy is applied in our groups to gain insights into the role of metal ions for the function and structure of large biomolecules. Specifically, NMR is used i) to investigate how metal ions bind to nucleic acids and thereby control the folding and structure of RNAs, ii) to characterize how metal ions are able to stabilize modified nucleic acids to be used as potential nanowires, and iii) to characterize the formation, structure, and role of the diverse metal clusters within plant metallothioneins. In this review we summarize the various NMR experiments applied and the information obtained, demonstrating the important and fascinating part NMR spectroscopy plays in the field of bioinorganic chemistry.