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Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Eggimann Gabriela A., Blattes Emilyne, Buschor Stefanie, Biswas Rasomoy, Kammer Stephan M., Darbre Tamis, Reymond Jean-Louis,
Project Exploring Peptide Topologies in Search for New Drugs
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Original article (peer-reviewed)

Journal ChemComm
Volume (Issue) 2014(50)
Page(s) 7254 - 7257
Title of proceedings ChemComm
DOI 10.1039/c4cc02780a

Abstract

Redesigning linear cell penetrating peptides (CPPs) into a multi-branched topology with short dipeptide branches gave cell penetrating peptide dendrimers (CPPDs) with higher cell penetration, lower toxicity and hemolysis and higher serum stability than linear CPPs. Their use is demonstrated by delivering a cytotoxic peptide and paclitaxel into cells.
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