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Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells
Type of publication
Peer-reviewed
Publikationsform
Original article (peer-reviewed)
Author
Eggimann Gabriela A., Blattes Emilyne, Buschor Stefanie, Biswas Rasomoy, Kammer Stephan M., Darbre Tamis, Reymond Jean-Louis,
Project
Exploring Peptide Topologies in Search for New Drugs
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Original article (peer-reviewed)
Journal
ChemComm
Volume (Issue)
2014(50)
Page(s)
7254 - 7257
Title of proceedings
ChemComm
DOI
10.1039/c4cc02780a
Abstract
Redesigning linear cell penetrating peptides (CPPs) into a multi-branched topology with short dipeptide branches gave cell penetrating peptide dendrimers (CPPDs) with higher cell penetration, lower toxicity and hemolysis and higher serum stability than linear CPPs. Their use is demonstrated by delivering a cytotoxic peptide and paclitaxel into cells.
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