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In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Evina Jean Noel, Bikobo Dominique Serge Ngono, Zintchem Auguste Abouem A., Nyemeck Norbert Mbabi, Ndedi Esther Del Florence Moni, Diboué Patrick Hervé Betote, Nyegue Maximilienne Ascension, Atchadé Alex de Théodore, Pegnyemb Dieudonné Emmanuel, Koert Ulrich, Bochet Christian G.,
Project Photons in organic synthesis
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Original article (peer-reviewed)

Journal Revista Brasileira de Farmacognosia
Volume (Issue) 27(6)
Page(s) 739 - 743
Title of proceedings Revista Brasileira de Farmacognosia
DOI 10.1016/j.bjp.2017.09.006

Open Access

URL http://doi.org/10.1016/j.bjp.2017.09.006
Type of Open Access Publisher (Gold Open Access)

Abstract

A new C-glycosylflavone, apigenin 7-Me ether 6-C-[β-xylopyranosyl-(1→3)-β-glucopyranoside] named distemonanthoside was isolated from the stem bark of Distemonanthus benthamianus Baill., Fabaceae, along with six known compds., sitosterol 3-O-β-D-glucopyranoside, 4-methoxygallic acid, syringic acid, quercetin, 6''-O-acetylvitexin, quercetin 3-O-β-D-glucopyranoside.  The structures of those compds. and others were detd. through spectral analyses.  Compds. distemonanthoside, sitosterol 3-O-β-D-glucopyranoside, 4-methoxygallic acid and quercetin were tested against a clin. isolate strain of Mycobacterium tuberculosis AC 45; they exhibited good to moderate antitubercular activities with MIC values ranged from 31.25 to 125 μg/mL.
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