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Interactions of biodegradable poly([R]-3-hydroxy-10-undecenoate) with DOPC lipid: a monolayer study

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2011
Author Jagoda A., Ketikidis P., Zinn M., Meier W., Kita-Tokarczyk K.,
Project Nanostructured Polymers
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Original article (peer-reviewed)

Journal Langmuir
Volume (Issue) 27
Page(s) 10878 - 10885
Title of proceedings Langmuir
DOI 10.1021/la201654d

Open Access

URL http://pubs.acs.org/doi/pdf/10.1021/la201654d
Type of Open Access Website

Abstract

Polyhydroxyalkanoates (PHAs) are biodegradable, biocompatible polyesters and very attractive candidates for biomedical applications as materials for tissue engineering. They have a hydrophobic character, but some are able to spread at the air water interface to form monomolecularly thin films (Langmuir monolayers). This is a very convenient model to analyze PHA self-assembly in two dimensions and to study their molecular interactions with other amphiphilic compounds, which is very important considering compatibility between biomaterials and cell membranes. We used the Langmuir monolayer technique and Brewster angle microscopy to study the properties of poly([R]-3-hydroxy-10-undecenoate) (PHUE) films on the free water surface in various experimental conditions. Moreover, we investigated the interactions between the polymer and one of the main biomembrane components, 1,2-dioleoyl-snglycero- 3-phosphocholine (DOPC). The addition of lipid to a polymer film does not change the monolayer phase behavior; however, the interactions between these two materials are repulsive and fall in two composition-dependent regimes. In summary, this is the first systematic study of the monolayer behavior of PHUE, thus forming a solid basis for a thorough understanding of material interactions, in particular in the context of biomaterials and implants.
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