Publication

Back to overview

Stereological analysis of the rat and monkey amygdala.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Chareyron Loïc J, Banta Lavenex Pamela, Amaral David G, Lavenex Pierre,
Project Postnatal development of the hippocampal formation: neuroanatomical and plasticity studies in monkeys
Show all

Original article (peer-reviewed)

Journal The Journal of comparative neurology
Volume (Issue) 519(16)
Page(s) 3218 - 39
Title of proceedings The Journal of comparative neurology
DOI 10.1002/cne.22677

Open Access

URL http://doc.rero.ch/record/28170?ln=fr
Type of Open Access Repository (Green Open Access)

Abstract

The amygdala is part of a neural network that contributes to the regulation of emotional behaviors. Rodents, especially rats, are used extensively as model organisms to decipher the functions of specific amygdala nuclei, in particular in relation to fear and emotional learning. Analysis of the role of the nonhuman primate amygdala in these functions has lagged work in the rodent but provides evidence for conservation of basic functions across species. Here we provide quantitative information regarding the morphological characteristics of the main amygdala nuclei in rats and monkeys, including neuron and glial cell numbers, neuronal soma size, and individual nuclei volumes. The volumes of the lateral, basal, and accessory basal nuclei were, respectively, 32, 39, and 39 times larger in monkeys than in rats. In contrast, the central and medial nuclei were only 8 and 4 times larger in monkeys than in rats. The numbers of neurons in the lateral, basal, and accessory basal nuclei were 14, 11, and 16 times greater in monkeys than in rats, whereas the numbers of neurons in the central and medial nuclei were only 2.3 and 1.5 times greater in monkeys than in rats. Neuron density was between 2.4 and 3.7 times lower in monkeys than in rats, whereas glial density was only between 1.1 and 1.7 times lower in monkeys than in rats. We compare our data in rats and monkeys with those previously published in humans and discuss the theoretical and functional implications that derive from our quantitative structural findings.
-