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Attenuation correction maps for SPECT myocardial perfusion imaging from contrast-enhanced coronary CT angiography: gemstone spectral imaging with single-source dual energy and material decomposition.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2013
Author Fuchs Tobias A, Sah Bert-Ram, Stehli Julia, Bull Sacha, Dougoud Svetlana, Huellner Martin W, Gaemperli Oliver, Kaufmann Philipp A,
Project Entwicklung einer neuen Hybrid-Bildgebungs-Methode zur nicht invasiven kardialen Diagnostik
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Original article (peer-reviewed)

Journal Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume (Issue) 54(12)
Page(s) 2077 - 80
Title of proceedings Journal of nuclear medicine : official publication, Society of Nuclear Medicine
DOI 10.2967/jnumed.113.123570

Abstract

UNLABELLED The aim of this study was to explore the feasibility of attenuation correction (AC) of myocardial perfusion imaging (MPI) with a virtual unenhanced cardiac CT scan synthesized from contrast-enhanced single-source dual-energy coronary CT angiography. METHODS Segmental myocardial percentage uptake values obtained with AC were analyzed by use of correlation analysis and Bland-Altman limits of agreement (20-segment model), and clinical agreement was evaluated in 30 patients. RESULTS The 2 methods showed an excellent correlation for segmental myocardial percentage uptake at stress (r = 0.93; P < 0.001; low dose) and at rest (r = 0.90; P < 0.001; high dose) with narrow Bland-Altman limits of agreement (-6.8% to 7.8% and -7.8% to 7.4%, respectively). The levels of clinical agreement of SPECT MPI corrected with standard versus virtual unenhanced CT AC were 99% per coronary territory and 97% per patient. CONCLUSION Our results suggest that AC of SPECT MPI with a virtual unenhanced CT scan synthesized from contrast-enhanced coronary CT angiography is feasible and reliable.
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