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Contortamide, a new anti-colon cancer cerebroside and other constituents from Tabernaemontana contorta Stapf (Apocynaceae)

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Ebede Guy R., Ndongo Joseph T., Mbing Joséphine N., Kenfack Hector C. M., Pegnyemb Dieudonné E., Bochet Christian G.,
Project Photons in organic synthesis
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Original article (peer-reviewed)

Journal Natural Product Research
Page(s) 1 - 9
Title of proceedings Natural Product Research
DOI 10.1080/14786419.2019.1636243


A new cerebroside, Contortamide (1) together with nine known compds. spegatrine (2), affinisine (3), Nb-methylaffinisine (4), ursolic acid (5), α-amyrin (6), bauerenol acetate (7), lupeol (8), betulinic acid (9) and β-sitosterolglycoside (10) were isolated from the trunk bark of Tabernaemontana contorta Stapf.  The new compd. 1 showed significant activity against Caco-2 colon cancer cells with the MTT method.  Compds.1-4 and 6-9 were isolated for the first time from this species.