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Towards a photochemical synthesis of peptides.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2013
Author Bochet Christian G,
Project Photons in organic synthesis
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Original article (peer-reviewed)

Journal Chimia
Volume (Issue) 67(12-13)
Page(s) 896 - 8
Title of proceedings Chimia
DOI 10.2533/chimia.2013.896


The laboratory preparation of peptides, once a challenge, is now a standard operation that can be automatised. However, the need for particular protecting groups requiring relatively harsh conditions for their removal (strong acids or bases) and reactive coupling agents can be problematic in specific cases (e.g. in a cell or in a microfluidic device). In this account, we describe our efforts towards a fully photochemical approach to peptide synthesis, where both the coupling and the deprotection steps use light instead of reagents. In order to selectively promote one of the two steps at a time, monochromatic light is used.