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The organization of submodality-specific touch afferent inputs in the vibrissa column.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2013
Author Sakurai Katsuyasu, Akiyama Masahiro, Cai Bin, Scott Alexandra, Han Bao-Xia, Takatoh Jun, Sigrist Markus, Arber Silvia, Wang Fan,
Project Entwicklung und Funktion von motorischen Netzwerken
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Original article (peer-reviewed)

Journal Cell reports
Volume (Issue) 5(1)
Page(s) 87 - 98
Title of proceedings Cell reports
DOI 10.1016/j.celrep.2013.08.051

Open Access

URL http://www.cell.com/cell-reports/pdf/S2211-1247(13)00511-1.pdf
Type of Open Access Publisher (Gold Open Access)

Abstract

The rodent tactile vibrissae are innervated by several different types of touch sensory neurons. The central afferents of all touch neurons from one vibrissa collectively project to a columnar structure called a barrelette in the brainstem. Delineating how distinct types of sensors connect to second-order neurons within each barrelette is critical for understanding tactile information coding and processing. Using genetic and viral techniques, we labeled slowly adapting (SA) mechanosensory neurons, rapidly adapting (RA) mechanosensory neurons, afferent synapses, and second-order projection neurons with four different fluorescent markers to examine their connectivity. We discovered that within each vibrissa column, individual sensory neurons project collaterals to multiply distributed locations, inputs from SA and RA afferents are spatially intermixed without any discernible stereotypy or topography, and second-order projection neurons receive convergent SA and RA inputs. Our findings reveal a "one-to-many and many-to-one" connectivity scheme and the circuit architecture for tactile information processing at the first-order synapses.
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