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HIV and Aging – Perhaps Not as Dramatic as We Feared?

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Engel Tanja, Raffenberg Marieke, Marzolini Catia, Cavassini Matthias, Kovari Helen, Hasse Barbara, Tarr Philip E.,
Project Dynamics of atherosclerosis progression in HIV-infected and HIV-uninfected persons - a longitudinal study using coronary computed tomography angiography
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Original article (peer-reviewed)

Journal Gerontology
Volume (Issue) 64(5)
Page(s) 446 - 456
Title of proceedings Gerontology
DOI 10.1159/000489172

Abstract

Ever since the introduction of highly active antiretroviral therapy (ART) in 1995, HIV infection has been linked to "metabolic" complications (insulin resistance, dyslipidemia, osteoporosis, and others). Studies suggested increased rates of myocardial infarction, renal insufficiency, neurocognitive dysfunction, and fractures in HIV-postitive patients. Even long-term suppression of HIV seemed to be accompanied by an excess of deleterious inflammation that could promote these complications. The aims of this viewpoint paper are to summarize recent data and to examine the possibility that the problem of aging-related morbidity in HIV might not be as dramatic as previously believed.
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