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Correlates of broadly neutralizing antibody development

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Abela Irene A., Kadelka Claus, Trkola Alexandra,
Project Understanding HIV-1 broadly neutralizing antibody evolution - The Swiss 4.5K Screen
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Review article (peer-reviewed)

Journal Current Opinion in HIV and AIDS
Volume (Issue) 14(4)
Page(s) 279 - 285
Title of proceedings Current Opinion in HIV and AIDS
DOI 10.1097/coh.0000000000000552


Focused efforts of recent years have unraveled a multiply layered process of HIV-1 bnAb development. As it is understood today, bnAb evolution can be triggered and influenced by a range of factors and several different pathways may exist how bnAb induction and maturation can occur. To capitalize on the gained knowledge, future research needs to validate factors to identify independent drivers of bnAb induction to advance vaccine design.