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tRNA Biology in Trypanosomes

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Shikha Shikha, Brogli Rebecca, Schneider André, Polacek Norbert,
Project Stress-mediated effects on ribosome functions and translation control
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Review article (peer-reviewed)

Journal CHIMIA International Journal for Chemistry
Volume (Issue) 73(5)
Page(s) 395 - 405
Title of proceedings CHIMIA International Journal for Chemistry
DOI 10.2533/chimia.2019.395

Open Access


Besides their medical importance, the parasitic protozoan Trypanosoma brucei and its relatives are experimentally highly accessible model systems for many cell biological processes. Trypanosomes are phylogenetically essentially unrelated to the popular model eukaryotes, such as yeast and animals, and thus show several unique features, many of which are connected to RNA. Here we review the tRNA biology of trypanosomes. Even though tRNAs were already discovered 60 years ago, owing to current technological advances in the field, research on tRNA biology has seen a Renaissance in recent years. First we discuss the extensive mitochondrial tRNA import process and the consequences it has for the parasite. Next we focus on trypanosomal aminoacyl-tRNA synthetases, some of which may be exploited as drug targets. Furthermore, we summarize what is known about trypanosomal tRNA modifications in both the cytosol and the mitochondrion. Finally, we provide an overview on the emerging field of tRNA-derived fragments and their possible function as translation regulators.