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Plant development regulated by cytokinin sinks

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Evelyne Zürcher, Jingchun Liu, Martin di Donato, Markus Geisler, Bruno Müller,
Project Defining Specificity in Cytokinin Ligand Localization and Signaling Interpretation
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Original article (peer-reviewed)

Journal Science
Volume (Issue) 353(6303)
Page(s) 1027 - 1030
Title of proceedings Science
DOI 10.1126/science.aaf7254


Morphogenetic signals control the patterning of multicellular organisms. Cytokinins are mobile signals that are perceived by subsets of plant cells.We found that the responses to cytokinin signaling during Arabidopsis development are constrained by the transporter PURINE PERMEASE 14 (PUP14). In our experiments, the expression of PUP14 was inversely correlated to the cytokinin signaling readout. Loss of PUP14 function allowed ectopic cytokinin signaling accompanied by aberrant morphogenesis in embryos, roots, and the shoot apical meristem. PUP14 protein localized to the plasma membrane and imported bioactive cytokinins, thus depleting apoplastic cytokinin pools and inhibiting perception by plasma membrane–localized cytokinin sensors.We propose that the spatiotemporal cytokinin sink patterns established by PUP14 determine the cytokinin signaling landscape that shapes the morphogenesis of land plants.