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T-cell trafficking in the central nervous system

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Publication date 2012
Author Sallusto F, Impellizzieri D, Basso C, Laroni A, Uccelli A, Lanzavecchia A, Engelhardt B,
Project Cell Migration
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Review article (peer-reviewed)

Journal IMMUNOLOGICAL REVIEWS
Volume (Issue) 248
Page(s) 216 - 227
Title of proceedings IMMUNOLOGICAL REVIEWS

Abstract

To perform their distinct effector functions, pathogen-specific T cells have to migrate to target tissue where they recognize antigens and produce cytokines that elicit appropriate types of protective responses. Similarly, migration of pathogenic self-reactive T cells to target organs is an essential step required for tissue-specific autoimmunity. In this article, we review data from our laboratory as well as other laboratories that have established that effector function and migratory capacity are coordinately regulated in different T-cell subsets. We then describe how pathogenic T cells can enter into intact or inflamed central nervous system (CNS) to cause experimental autoimmune encephalomyelitis or multiple sclerosis. In particular, we elaborate on the role of CCR6/CCL20 axis in migration through the choroid plexus and the involvement of this pathway in immune surveillance of and autoimmunity in the CNS.
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