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Multivalent glycoconjugates as anti-pathogenic agents.

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Bernardi Anna, Jiménez-Barbero Jesus, Casnati Alessandro, De Castro Cristina, Darbre Tamis, Fieschi Franck, Finne Jukka, Funken Horst, Jaeger Karl-Erich, Lahmann Martina, Lindhorst Thisbe K, Marradi Marco, Messner Paul, Molinaro Antonio, Murphy Paul V, Nativi Cristina, Oscarson Stefan, Penadés Soledad, Peri Francesco, Pieters Roland J, Renaudet Olivier, Reymond Jean-Louis, Richichi Barbara, Rojo Javier, Sansone Francesco,
Project Exploring Peptide Topologies in Search for New Drugs
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Review article (peer-reviewed)

Journal Chemical Society reviews
Volume (Issue) 42(11)
Page(s) 4709 - 27
Title of proceedings Chemical Society reviews
DOI 10.1039/c2cs35408j

Abstract

Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein-glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.
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