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Real-time protein aggregation monitoring based on a simultaneous light scattering investigation and a Bloch surface wave-based approach

Type of publication	Not peer-reviewed
Publikationsform	Original article (non peer-reviewed)
Publication date	2015
Author	Santi Sara, Barakat Elsie, Neier Reinhard, Herzig Hans Peter,
Project	The hydrogenation of calix[4]pyrroles leading to the novel ligand system calix[4]pyrrolidine: Their properties and their application

Type of publication

Not peer-reviewed

Publikationsform

Original article (non peer-reviewed)

Publication date

2015

Author

Santi Sara, Barakat Elsie, Neier Reinhard, Herzig Hans Peter,

Project

The hydrogenation of calix[4]pyrroles leading to the novel ligand system calix[4]pyrrolidine: Their properties and their application

Show all

Original article (non peer-reviewed)

Journal	Proceedings of SPIE
Volume (Issue)	9550(95500V)
Page(s)	1 - 3
Title of proceedings	Proceedings of SPIE
DOI	10.1117/12.2188595

Abstract

We present a study of the dynamics of protein aggregation using a Bloch surface wave (BSW) label-free sensing scheme. In a previous work, we demonstrated the ability to detect the early dynamic events of fibrillogenesis of amyloid betapeptides (Aβ), linked to Alzheimer’s Disease. Here, we demonstrate the efficacy of the BSW sensor by describing a simultaneous light scattering measurement, with the purpose of real-time monitoring the size change of the Aβ aggregates, throughout fibrillization.