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Real-time protein aggregation monitoring based on a simultaneous light scattering investigation and a Bloch surface wave-based approach

Type of publication Not peer-reviewed
Publikationsform Original article (non peer-reviewed)
Publication date 2015
Author Santi Sara, Barakat Elsie, Neier Reinhard, Herzig Hans Peter,
Project The hydrogenation of calix[4]pyrroles leading to the novel ligand system calix[4]pyrrolidine: Their properties and their application
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Original article (non peer-reviewed)

Journal Proceedings of SPIE
Volume (Issue) 9550(95500V)
Page(s) 1 - 3
Title of proceedings Proceedings of SPIE
DOI 10.1117/12.2188595


We present a study of the dynamics of protein aggregation using a Bloch surface wave (BSW) label-free sensing scheme. In a previous work, we demonstrated the ability to detect the early dynamic events of fibrillogenesis of amyloid betapeptides (Aβ), linked to Alzheimer’s Disease. Here, we demonstrate the efficacy of the BSW sensor by describing a simultaneous light scattering measurement, with the purpose of real-time monitoring the size change of the Aβ aggregates, throughout fibrillization.