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Single-Metabolite Bio-Nano-Sensors and System for Remote Monitoring in Animal Model,

Type of publication Peer-reviewed
Publikationsform Proceedings (peer-reviewed)
Author Sandro Carrara Léandre Bolomey Cristina Boero Andrea Cavallini Eric Meurville Giovanni De Mi,
Project Innovative Enabling Micro-Nano-Bio-technologies for Implantable systems in molecular medicine and personalized therapy
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Proceedings (peer-reviewed)

Title of proceedings IEEE Sensors Conference proceedings


A novel system for remote monitoring of metabolism in animal model is proposed in this paper. The system is obtained by integrating Bio-Nano-Sensors to detect single- metabolites, an electrochemical front-end made with off- the-shelf components, an RF communication sub-system, and an antenna of new design. The system has been calibrated and tested for continuous monitoring of four different metabolites: glucose, lactate, glutamate, and adenosine triphosphate (ATP). Tests with animal models (mice) have been conducted to investigate tissue inflammation induced by the implanted Bio-Nano- Sensors. The tests confirmed that our system is suitable and reliable for remote monitoring of single-metabolites in experiments with animal models