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HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Loiseau Chloé, Brites Daniela, Reinhard Miriam, Zürcher Kathrin, Borrell Sonia, Ballif Marie, Fenner Lukas, Cox Helen, Rutaihwa Liliana K., Wilkinson Robert J., Yotebieng Marcel, Carter E. Jane, Abimiku Alash'le, Marcy Olivier, Gotuzzo Eduardo, Avihingsanon Anchalee, Zetola Nicola, Doulla Basra, Böttger Erik C., Egger Matthias, Gagneux Sebastien,
Project Forschungspauschale Forschungsratspräsident SNF
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Original article (peer-reviewed)

Journal Antimicrobial Agents and Chemotherapy
Volume (Issue) 64(10)
Page(s) e00782-20
Title of proceedings Antimicrobial Agents and Chemotherapy
DOI 10.1128/aac.00782-20

Open Access

URL http://doi.org/10.1128/AAC.00782-20
Type of Open Access Green OA Embargo (Freely available via Repository after an embargo)

Abstract

ABSTRACT We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.
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