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Towards Targeted Drug Delivery by Covalent Ligand-Modified Polymeric Nanocontainers

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2010
Author Egli S., Fischer B., Hartmann S., Hunziker P., Meier W., Rigler P.,
Project Nanostructured Polymers
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Original article (peer-reviewed)

Journal Modern Trends in Polymer Science-Epf 09
Volume (Issue) 296
Page(s) 278 - 285
Title of proceedings Modern Trends in Polymer Science-Epf 09
DOI 10.1002/masy.201051039

Open Access

Abstract

Here we present a novel strategy for specific cellular targeting of polymeric nanocontainers by using self-assembly of block copolymers consisting of either Polydimethoxysiloxane-b-Polymethyloxazoline-b-Polydimethoxysiloxane (PDMS-b-PMOXA-b-PDMS) or functionalized PDMS-b-PMOXA-b-PDMS. Covalent functionalization of the above copolymer was accomplished using either the fluorescent dye sulforhodamine B or a poly-guanosin ligand, the latter by using the Huisgen 1,3-dipolar cycloaddition. The success of the covalent modification of the block copolymer has been determined by studying functionalized sulforhodamine B by NMR and fluorescence correlation spectroscopy. The covalent click chemistry approach leads to efficiently functionalized polymeric nanocontainers which enables specific uptake by activated macrophages overexpressing the scavenger receptor A1.
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