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Phase Behavior of Vesicle-Forming Block Copolymers in Aqueous Solutions

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2011
Author Braun J., Bruns N., Pfohl T., Meier W.,
Project Nanostructured Polymers
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Original article (peer-reviewed)

Journal Macromolecular Chemistry and Physics
Volume (Issue) 212(12)
Page(s) 1245 - 1254
Title of proceedings Macromolecular Chemistry and Physics
DOI 10.1002/macp.201100012

Open Access


The binary phase diagram of amphiphilic poly(ethylene oxide)-block-poly(g-methyl-e-caprolactone) block copolymers in water is examined for four polymers having the same hydrophilic block length but different hydrophobic block lengths across the whole concentration range. The bulk polymers show no ordered morphology. With increasing water concentration the polymers undergo transitions from lamellar phases to packed vesicles and subsequently all polymers self-assemble into vesicles in dilute aqueous solutions. Additionally, the largest polymer forms an inverse hexagonal phase, and the smallest polymer self-aggregates into rod-like micelles and showed a hexagonal phase.