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Quality Management in in vivo proton MRS

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Pedrosa de Barros Nuno, Johannes Slotboom,
Project Establishing Novel MR Criteria for the Assessment of Malignant Glioma Progression
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Review article (peer-reviewed)

Journal Analytical Biochemistry
Title of proceedings Analytical Biochemistry


The quality of MR-Spectroscopy data can easily be affected in in vivo applications. Several factors may produce signal artefacts, and often these are not easily detected, not even by experienced spectroscopists. Reliable and reproducible in vivo MRS-data requires the definition of quality requirements and goals, implementation of measures to guarantee quality standards, regular control of data quality, and a continuous search for quality improvement. The first part of this review includes a general introduction to different aspects of quality management in MRS. It is followed by the description of a series of tests and phantoms that can be used to assure the quality of the MR system. In the third part, several methods and strategies used for quality control of the spectroscopy data are presented. This review concludes with a reference to a few interesting techniques and aspects that may help to further improve the quality of in vivo MR-spectra.