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Genetic screening for metabolic and age-related complications in HIV-infected persons.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2010
Author Tarr Philip E, Telenti Amalio,
Project Contribution of multiple genetic variants, identified in genome-wide association studies, to coronary artery disease in HIV-infected individuals
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Original article (peer-reviewed)

Journal F1000 medicine reports
Volume (Issue) 2
Page(s) 83 - 83
Title of proceedings F1000 medicine reports
DOI 10.3410/M2-83

Abstract

Genetic screening for HIV-related complications is emerging as a clinically relevant prediction tool. A number of single nucleotide polymorphisms associated with conditions such as dyslipidemia and type 2 diabetes have been identified in both the general population and in HIV-infected individuals. Additionally, genome-wide association studies have looked at hepatitis C susceptibility in HIV-infected people, and genetic studies are ongoing for coronary artery disease, osteoporosis, and neurocognitive dysfunction. To date, understanding the contribution of genetic variation to the pathogenesis of lipoatrophy and kidney disease in HIV-infection is limited.
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