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Dynamic control of endogenous retroviruses during development.

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Publication date 2011
Author Rowe Helen M, Trono Didier,
Project KRAB/KAP1 epigenetic regulation in the control of memory and emotional traits: from mice to humans.
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Review article (peer-reviewed)

Journal Virology
Volume (Issue) 411(2)
Page(s) 273 - 87
Title of proceedings Virology
DOI 10.1016/j.virol.2010.12.007

Abstract

Close to half of the human genome encompasses mobile genetic elements, most of which are retrotransposons. These genetic invaders are formidable evolutionary forces that have shaped the architecture of the genomes of higher organisms, with some conserving the ability to induce new integrants within their hosts' genome. Expectedly, the control of endogenous retroviruses is tight and multi-pronged. It is most crucially established in the germ line and during the first steps of embryogenesis, primarily through transcriptional mechanisms that have likely evolved under their very pressure, but are now engaged in controlling gene expression at large, notably during early development.
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