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Combining Topology and Sequence Design for the Discovery of Potent Antimicrobial Peptide Dendrimers against Multidrug-Resistant Pseudomonas aeruginosa

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Stach Michaela, Siriwardena Thissa, Köhler Thilo, van Delden Christian, Darbre Tamis, Reymond Jean-Louis,
Project Exploring Peptide Topologies in Search for New Drugs
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Original article (peer-reviewed)

Journal Angewandte Chemie
Volume (Issue) 2014(53)
Page(s) 1 - 6
Title of proceedings Angewandte Chemie
DOI 10.1002/anie.201409270


Multidrug-resistant opportunistic bacteria, such as Pseudomonas aeruginosa, represent a major public health threat. Antimicrobial peptides (AMPs) and related peptidomi- metic systems offer an attractive opportunity to control these pathogens. AMP dendrimers (AMPDs) with high activity against multidrug-resistant clinical isolates of P. aeruginosa and Acinetobacter baumannii were now identified by a system- atic survey of the peptide sequences within the branches of a distinct type of third-generation peptide dendrimers. Com- bined topology and peptide sequence design as illustrated here represents a new and general strategy to discover new antimicrobial agents to fight multidrug-resistant bacterial pathogens.