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Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Tiam Eric Robert, Ngono Bikobo Dominique Serge, Abouem A Zintchem Auguste, Mbabi Nyemeck Norbert, Moni Ndedi Esther Del Florence, Betote Diboué Patrick Hervé, Nyegue Maximilienne Ascension, Atchadé Alex de Théodore, Emmanuel Pegnyemb Dieudonné, Bochet Christian G., Koert Ulrich,
Project Photons in organic synthesis
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Original article (peer-reviewed)

Journal Natural Product Research
Volume (Issue) 33(5)
Page(s) 642 - 650
Title of proceedings Natural Product Research
DOI 10.1080/14786419.2017.1402324

Abstract

Triclisinone, a new ochnaflavone deriv., was isolated from the aerial parts of Triclisia gilletii, along with known drypemolundein B and eight other known compds.  The chem. shifts of drypemolundein B have been partially revised based on reinterpretation of NMR spectroscopic data.  The eight other secondary metabolites are composed of: (+)-nonacosan-10-ol; stigmasterol, 3-O-β-D-glucopyranosylsitosterol, 3-O-β-D-glucopyranosylstigmasterol; oleanic acid; myricetin, quercetin and 3-methoxyquercetin.  Their structures were elucidated using IR, MS, NMR 1D and 2D, 1H and 13C and comparison with literature data.  Furthermore, compds., and the crude ext. were tested against Mycobacterium tuberculosis.  Compds. and displayed moderate to very good activity against resistant strain (codified AC 45) of M. tuberculosis with min. inhibitory concns. MICs ranging from 3.90 to 62.5 μg/mL.
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