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Shear-stress sensitive lenticular vesicles for targeted drug delivery

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2012
Author Holme Margaret N., Fedotenko Illya A., Abegg Daniel, Althaus Jasmin, Babel Lucille, Favarger France, Reiter Renate, Tǎnǎsescu Radu, Zaffalon Pierre Léonard, Ziegler André E., Müller Bert H., Saxer Till, Zumbuehl Andreas,
Project Approaches for Non-spherical and Surface Activated Liposomes
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Original article (peer-reviewed)

Journal Nature Nanotechnology
Volume (Issue) 7(8)
Page(s) 536 - 543
Title of proceedings Nature Nanotechnology
DOI 10.1038/nnano.2012.84

Abstract

Atherosclerosis results in the narrowing of arterial blood vessels and this causes significant changes in the endogenous shear stress between healthy and constricted arteries. Nanocontainers that can release drugs locally with such rheological changes can be very useful. Here, we show that vesicles made from an artificial 1,3-diaminophospholipid are stable under static conditions but release their contents at elevated shear stress. These vesicles have a lenticular morphology, which potentially leads to instabilities along their equator. Using a model cardiovascular system based on polymer tubes and an external pump to represent shear stress in healthy and constricted vessels of the heart, we show that drugs preferentially release from the vesicles in constricted vessels that have high shear stress. © 2012 Macmillan Publishers Limited. All rights reserved.
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