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Body mass index and the prevalence, severity, and risk of coronary artery disease: An international multicentre study of 13 874 patients

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2013
Author Labounty Troy M., Gomez Millie J., Achenbach Stephan, Al-Mallah Mouaz Husayn, Berman Daniel S., Budoff Matthew Jay, Cademartiri Filippo, Callister Tracy Q., Chang HyukJae, Cheng Victor, Chinnaiyan Kavitha M., Chow Benjamin J. W., Cury Ricardo Caldeira, Delago Augustin J., Dunning Allison L., Feuchtner Gudrun Maria, Hadamitzky Martin, Hausleiter Jörg, Kaufmann Philipp Antonio, Kim YongJin, Leipsic Jonathon Avrom, Lin Fay, Maffei Erica, Raff Gilbert L., Shaw Leslee J.,
Project Entwicklung einer neuen Hybrid-Bildgebungs-Methode zur nicht invasiven kardialen Diagnostik
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Original article (peer-reviewed)

Journal European Heart Journal Cardiovascular Imaging
Volume (Issue) 14(5)
Page(s) 456 - 463
Title of proceedings European Heart Journal Cardiovascular Imaging
DOI 10.1093/ehjci/jes179

Abstract

AimsObesity is associated with the presence of coronary artery disease (CAD) risk factors and cardiovascular events. We examined the relationship between body mass index (BMI) and the presence, extent, severity, and risk of CAD in patients referred for coronary computed tomographic angiography (CCTA).Methods and resultsWe evaluated 13 874 patients from a prospective, international, multicentre registry of individuals without known CAD undergoing CCTA. We compared risk factors, CAD findings, and risk of all-cause mortality and non-fatal myocardial infarction (MI) amongst individuals with underweight (18.5-20.0 kg/m2), normal (20.1-24.9 kg/m2), overweight (25-29.9 kg/m2), and obese (≥30 kg/m2) BMI. The mean follow-up was 2.4 ± 1.2 years with 143 deaths and 193 MIs. Among underweight, normal weight, overweight, and obese individuals, there was increasing prevalence of diabetes (7 vs.10% vs. 12 vs. 19%), hypertension (37 vs. 40% vs. 46 vs. 59%), and hyperlipidaemia (48 vs. 52% vs. 56 vs. 56%; P < 0.001 for trend). After multivariable adjustment, BMI was positively associated with the prevalence of any CAD [odds ratio (OR) 1.25 per +5 kg/m2, 95% confidence interval (CI): 1.20-1.30, P < 0.001] and obstructive (≥50% stenosis) CAD (OR: 1.13 per +5 kg/m2, 95% CI: 1.08-1.19, P < 0.001); a higher BMI was also associated with an increased number of segments with plaque (+0.26 segments per +5 kg/m2, 95% CI: 0.22-0.30, P < 0.001). Larger BMI categories were associated with an increase in all-cause mortality (P = 0.004), but no difference in non-fatal MI. After multivariable adjustment, a higher BMI was independently associated with increased risk of MI (hazards ratio: 1.28 per +5 kg/m2, 95% CI: 1.12-1.45, P < 0.001).ConclusionsAmongst patients with suspected CAD referred for CCTA, individuals with increased BMI have greater prevalence, extent, and severity of CAD that is not fully explained by the presence of traditional risk factors. A higher BMI is independently associated with increased risk of intermediate-term risk of myocardial infarction. © The Author 2012.
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