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MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Banerjee S, Oneda B, Yap L M, Jewell D P, Matters G L, Fitzpatrick L R, Seibold F, Sterchi E E, Ahmad T, Lottaz D, Bond J S,
Project Meprins, membrane-bound and secreted Astacinmetalloproteinases: Function in intestinal Epithelium
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Original article (peer-reviewed)

Journal Mucosal immunology
Volume (Issue) 2(3)
Page(s) 220 - 31
Title of proceedings Mucosal immunology
DOI 10.1038/mi.2009.3


The MEP1A gene, located on human chromosome 6p (mouse chromosome 17) in a susceptibility region for inflammatory bowel disease (IBD), encodes the alpha-subunit of metalloproteinase meprin A, which is expressed in the intestinal epithelium. This study shows a genetic association of MEP1A with IBD in a cohort of ulcerative colitis (UC) patients. There were four single-nucleotide polymorphisms in the coding region (P=0.0012-0.04), and one in the 3'-untranslated region (P=2 x 10(-7)) that displayed associations with UC. Moreover, meprin-alpha mRNA was decreased in inflamed mucosa of IBD patients. Meprin-alpha knockout mice exhibited a more severe intestinal injury and inflammation than their wild-type counterparts following oral administration of dextran sulfate sodium. Collectively, the data implicate MEP1A as a UC susceptibility gene and indicate that decreased meprin-alpha expression is associated with intestinal inflammation in IBD patients and in a mouse experimental model of IBD.