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In Vitro Activity of the Novel Antimicrobial Peptide Dendrimer G3KL against Multidrug-Resistant Acinetobacter baumannii and Pseudomonas aeruginosa

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author PIres João, Siriwardena Thissa N., Stach Michaela, Tinguely Regula, Kasraian Sara, Luzzaro Francesco, Leib Stephen L., Darbre Tamis, Reymond Jean-Louis, Endimiani Andrea,
Project A Chemical Space Approach to Bioactive Peptides
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Original article (peer-reviewed)

Journal Antimicrobial Agents and Chemotherapy
Volume (Issue) 59(12)
Page(s) 7915 - 7918
Title of proceedings Antimicrobial Agents and Chemotherapy
DOI 10.1128/aac.01853-15

Open Access

Type of Open Access Website


The in vitro activity of the novel antimicrobial peptide dendrimer G3KL was evaluated against 32 Acinetobacter baumannii (including 10 OXA-23, 7 OXA-24, and 11 OXA-58 carbapenemase producers) and 35 Pseudomonas aeruginosa (including 18 VIM and 3 IMP carbapenemase producers) strains and compared to the activities of standard antibiotics. Overall, both species collections showed MIC50/90 values of 8/8 μg/ml and minimum bactericidal concentrations at which 50% or 90% of strains tested are killed (MBC50/90) of 8/8 μg/ml. G3KL is a promising molecule with antibacterial activity against multidrug-resistant and extensively drug-resistant A. baumannii and P. aeruginosa isolates.