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The Interleukin-20 Cytokines in Intestinal Diseases

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Niess Jan Hendrik, Hruz Petr, Kaymak Tanay,
Project The Role of IL-20 Cytokine Family Members in Eosinophilic Esophagitis
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Review article (peer-reviewed)

Journal Frontiers in Immunology
Volume (Issue) 9
Page(s) 1373
Title of proceedings Frontiers in Immunology
DOI 10.3389/fimmu.2018.01373

Open Access

Type of Open Access Publisher (Gold Open Access)


Autoimmune/inflammatory intestinal diseases, such as Crohn's disease and ulcerative colitis, infectious gastrointestinal diseases, and gastrointestinal cancers, such as colorectal cancer, are worldwide a significant health problem. Intercellular communication and direct contact with the environment as the microbiota colonizes the gastrointestinal surface facilitates these diseases. Cytokines mediate the intercellular communication to maintain the equilibrium between host and environment and to regulate immune responses. One cytokine family that exchange information between immune cells and epithelial cells is the IL-20 cytokine family which includes the cytokines IL-19, IL-20, IL-22, IL-24, and IL-26. These cytokines share common receptor subunits and signaling pathways. IL-22 is the most intensively studied cytokine within this family in contexts of gastrointestinal disease, but the importance of other family members is more and more appreciated. In this review, the potential function of IL-20 cytokines concerning gastrointestinal conditions is discussed.