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An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteria

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Di Bonaventura Ivan, Baeriswyl Stéphane, Capecchi Alice, Gan Bee-Ha, Jin Xian, Siriwardena Thissa N., He Runze, Köhler Thilo, Pompilio Arianna, Di Bonaventura Giovanni, van Delden Christian, Javor Sacha, Reymond Jean-Louis,
Project Controlling multi-antibiotic resistant bacteria with antimicrobial peptide dendrimers (AMPD)
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Original article (peer-reviewed)

Journal Chemical Communications
Volume (Issue) 54(40)
Page(s) 5130 - 5133
Title of proceedings Chemical Communications
DOI 10.1039/c8cc02412j

Open Access


Exploring chemical space can deliver novel antimicrobials against multidrug resistant bacteria. We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against several MDR strains of Acinetobacter baumannii and Pseudomonas aeruginosa.