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Magnetic resonance imaging based determination of body compartments with the versatile, interactive sparse sampling (VISS) method.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2012
Author Buehler Tania, Ramseier Nicolas, Machann Juergen, Schwenzer Nina F, Boesch Chris,
Project Multi-nuclear magnetic resonance spectroscopy (MRS) and imaging (MRI) on a clinical whole-body MR-system: insulin resistance, ageing, and physical activity
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Original article (peer-reviewed)

Journal Journal of magnetic resonance imaging : JMRI
Volume (Issue) 36(4)
Page(s) 951 - 60
Title of proceedings Journal of magnetic resonance imaging : JMRI
DOI 10.1002/jmri.23707

Abstract

PURPOSE To investigate the inhomogeneity of radiofrequency fields at higher field strengths that can interfere with established volumetric methods, in particular for the determination of visceral (VAT) and subcutaneous adipose tissue (SCAT). A versatile, interactive sparse sampling (VISS) method is proposed to determine VAT, SCAT, and also total body volume (TBV). MATERIALS AND METHODS VISS is based on a separation of major components by contour lines, followed by a sparse sampling algorithm, and eventually a quick manual correction. T1-weighted whole body scans of 24 subjects were evaluated (12 at 1.5T, 12 at 3.0T). RESULTS (a) Coefficients of variance (CV) and intra class correlation coefficients (ICC) determined within 3 raters (24 subjects) showed high consistency for SCAT (CV 2.2%, ICC 0.993) and VAT (CV 4.9%, ICC 0.987), (b) comparison with an established volumetric method revealed good agreement (Bland-Altman, VAT -0.68L to 1.07L, SCAT -2.18L to 8.39L), and (c) comparison of weights calculated from TBV with values measured on a scale resulted in an even better accuracy for VISS (Bland-Altman -1.98 kg to 4.09 kg) than for the reference method (-5.60 kg to 1.60 kg). CONCLUSION VISS is reproducible in particular within the same rater, accurate as compared with established methods, and robust against low contrast and inhomogeneity artifacts.
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