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X-ray micro computed tomography for the visualization of an atherosclerotic human coronary artery

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Matviykiv Sofiya, Buscema Marzia, Deyhle Hans, Pfohl Thomas, Zumbuehl Andreas, Saxer Till, Müller Bert,
Project Exploring Stable Phospholipid Membranes
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Original article (peer-reviewed)

Journal Journal of Physics: Conference Series
Volume (Issue) 849(1)
Page(s) 012002
Title of proceedings Journal of Physics: Conference Series
DOI 10.1088/1742-6596/849/1/012002

Abstract

© Published under licence by IOP Publishing Ltd. Atherosclerosis refers to narrowing or blocking of blood vessels that can lead to a heart attack, chest pain or stroke. Constricted segments of diseased arteries exhibit considerably increased wall shear stress, compared to the healthy ones. One of the possibilities to improve patient's treatment is the application of nano-therapeutic approaches, based on shear stress sensitive nano-containers. In order to tailor the chemical composition and subsequent physical properties of such liposomes, one has to know precisely the morphology of critically stenosed arteries at micrometre resolution. It is often obtained by means of histology, which has the drawback of offering only two-dimensional information. Additionally, it requires the artery to be decalcified before sectioning, which might lead to deformations within the tissue. Micro computed tomography (μCT) enables the three-dimensional (3D) visualization of soft and hard tissues at micrometre level. μCT allows lumen segmentation that is crucial for subsequent flow simulation analysis. In this communication, tomographic images of a human coronary artery before and after decalcification are qualitatively and quantitatively compared. We analyse the cross section of the diseased human coronary artery before and after decalcification, and calculate the lumen area of both samples.
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