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Liposome-Containing Mechanoresponsive Hydrogels

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Stalder E., Zumbuehl A.,
Project Exploring Stable Phospholipid Membranes
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Original article (peer-reviewed)

Journal Macromolecular Materials and Engineering
Volume (Issue) 302(5)
Page(s) 1600549
Title of proceedings Macromolecular Materials and Engineering
DOI 10.1002/mame.201600549

Abstract

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The direct injection of a drug into a joint can relieve osteoarthritic pain for a short period of time. The problem is that the drug will not stay at the allocated location. Therefore, a proof-of-concept in situ is designed forming hydrogel containing liposomes that are covalently linked to the hydrogel network. When the liposomes are filled with a cargo, the formed hydrogel is thus loaded with this cargo, too. Due to the link between the hydrogel and the liposomes, a compression or other mechanical force applied to the hydrogel will rupture the liposomes and release a small percentage of the cargo. Overall, a long-term intra-articular drug release is feasible. (Figure presented.).
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